Bioactive glass, bioactive glass gel and preparation method and application thereof

A technology of bioactive glass and gel, which is applied in drug combination, drug delivery, and pharmaceutical formulations, and can solve problems such as poor curative effect and inconvenient use

Active Publication Date: 2021-09-14
湖北中创医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing bioactive glass products for wound repair in the market are mainly powders and pastes, which are inconvenient to use and have relatively poor efficacy in promoting wound healing

Method used

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  • Bioactive glass, bioactive glass gel and preparation method and application thereof
  • Bioactive glass, bioactive glass gel and preparation method and application thereof
  • Bioactive glass, bioactive glass gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The present embodiment provides a kind of preparation method of bioactive glass, comprises the following steps:

[0036] S1, add silica gel, sodium nitrate, triethyl phosphate, calcium nitrate tetrahydrate and templating agent to hydrochloric acid aqueous solution (dilute 1-3mol / L hydrochloric acid solution to 0.05mol / L-0.2mol / L with deionized water) placed in 60°C at a speed of 300r / min and stirred for 4h to obtain a sol. Wherein, the molar ratio of silica gel, sodium nitrate, triethyl phosphate and calcium nitrate tetrahydrate is 60.1%:17.2%:19.3%:3.4%, and the mass percentage of template agent in the total mass of raw materials is 0.5%. The templating agent is polyethylene glycol 400. S2, aging the sol obtained in step S1 in an environment of 60° C. for 6 hours to obtain a wet gel.

[0037] S3, drying the wet gel obtained in step S2 in an environment of 105° C. for 6 hours to obtain a dry gel.

[0038] S4, placing the xerogel obtained in step S3 in an environment ...

Embodiment 2

[0045] This embodiment provides a bioactive glass gel, which is mainly composed of the following components in weight percentage, as shown in Table 1 below:

[0046] The composition table of the bioactive glass gel of table 1 embodiment 2

[0047]

[0048]

[0049] This embodiment also provides a preparation method of the bioactive glass gel, comprising the following steps:

[0050] S1, weigh each component according to the composition of the bioactive glass gel in Table 1.

[0051] S2, preprocessing:

[0052] Place the bioactive glass in an environment of 120±5°C for vacuum drying, heat and melt the medical vaseline and medical paraffin at 70±10°C respectively, and filter through a 200-mesh sieve while hot to remove impurities.

[0053] S3, put the heated and melted medical vaseline in a single-necked flask, heat and stir at 250r / min at 70±10°C, absorb the heated and melted medical paraffin with a syringe, and slowly inject it into the melted For medical vaseline, keep...

Embodiment 3

[0055] This embodiment provides a bioactive glass gel, which is mainly composed of the following components by weight percentage, as shown in Table 2 below:

[0056] The composition table of the bioactive glass gel of table 2 embodiment 3

[0057]

[0058]

[0059] This embodiment also provides a preparation method of the bioactive glass gel, comprising the following steps:

[0060] S1, weigh each component according to the composition of the bioactive glass gel in Table 2.

[0061] S2, preprocessing:

[0062] Place the bioactive glass in an environment of 120±5°C for vacuum drying, heat and melt the medical vaseline and medical paraffin at 70±10°C respectively, and filter through a 200-mesh sieve while hot to remove impurities.

[0063] S3, put the heated and melted medical vaseline in a single-necked flask, heat and stir at 150r / min at 70±10°C, absorb the heated and melted medical paraffin with a syringe, and slowly inject it into the melted For medical vaseline, ke...

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Abstract

The present invention relates to a kind of bioactive glass, bioactive glass gel and its preparation method and application. The preparation method of the bioactive glass comprises the following steps: silica gel, sodium nitrate, triethyl phosphate, calcium nitrate tetrahydrate and The templating agent is sequentially added to the hydrochloric acid aqueous solution, placed in an environment of 55°C-65°C, and stirred to obtain a sol; the sol is aged in an environment of 55°C-65°C to obtain a wet gel; the wet gel is placed in 100 Dry at ℃-110℃ to obtain xerogel; roast the xerogel at 450-550℃ to obtain a semi-finished product; pulverize the semi-finished product by airflow to obtain nano-scale bioactive glass. The bioactive glass prepared by the preparation method of the bioactive glass has nanoscale size and high activity, and at the same time, the heat treatment temperature can be controlled below 600° C., thereby saving energy consumption.

Description

technical field [0001] The invention relates to a bioactive glass, a bioactive glass gel, a preparation method and application thereof. Background technique [0002] The research and development and application of bioactive glass originated in the United States, and its main purpose is to develop a drug that can repair both skin and bone tissue. Bioactive glass was first proposed and developed by Professor Hench in 1971. It is currently the only bioactive material that "can repair and bond soft tissue and bone tissue at the same time". Compared with other biological materials, the material has better compatibility and safety. The main functions of bioactive glass are as follows: (1) It can enhance the bactericidal and antibacterial ability of the wound surface; (2) It can promote the dissolution of wound necrotic tissue and fibrinolysis, thereby producing enzyme serum creation; (3) It can create hypoxia environment, promote capillary formation, activate the release of vari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C4/00C03C3/097A61K9/06A61K33/42A61K47/06A61P17/02
CPCA61K9/0014A61K9/06A61K33/42A61K47/06A61P17/02C03C3/097C03C4/00
Inventor 宋炜张磊杜小青冯世忠
Owner 湖北中创医疗用品有限公司
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