A drug for improving aortic endothelial cell function and its application

A technology of endothelial cells and aorta, applied in the field of medicine, can solve the problems of high mortality and disability, high disease concealment, etc., and achieve the effect of preventing the occurrence and progression of vascular diseases, good application prospects, and prevention of occurrence and development

Active Publication Date: 2020-10-27
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, atherosclerosis has drugs, surgery and other treatment methods, but this type of disease is highly occult, and has a high rate of death and disability, so early prevention is particularly important. Studies have reported that natural active ingredients such as chlorogenic acid, Paeoniae alba and lignans have anti-atherosclerosis functions, and functional foods based on them have come out one after another

Method used

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  • A drug for improving aortic endothelial cell function and its application
  • A drug for improving aortic endothelial cell function and its application
  • A drug for improving aortic endothelial cell function and its application

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Experimental program
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Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with specific embodiments.

[0022] 1. Experimental materials

[0023] TRIzol reagent was purchased from Invitrogen; RNA reverse transcription kit and SYBR fluorescent dye were purchased from Dalian Bao Biological Company. RNA primer sequences were ordered and synthesized from Xi'an Qingke Jersey Biological Co., Ltd.

[0024] 2. Experimental cell culture and model establishment

[0025] Human aortic endothelial cells (HAEC) were purchased from Shanghai Baili Biotechnology Co., Ltd., and palmitic acid was purchased from Sigma. Cells were cultured in 95% air and 5% CO 2 in a constant temperature, humidified, sterile incubator at 37°C. The experiment was divided into three groups: (1) control group; (2) 500 μM palmitic acid treatment group; (3) drug protection group provided by the present invention.

[0026] 3. Experimental method

[0027] (1) mRNA content detection of interleukin-6 and m...

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Abstract

The disclosure relates to a composition for improving aortic endothelial cell function and use thereof. The composition includes acetic acid, lactic acid, polyoxyethylene castor oil, and disodium alkyl polyoxyethylene sulfosuccinate. The composition is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by saturated fatty acids, increasing a mitochondrial respiration and metabolism of vascular endothelial cells, and preventing an occurrence and progression of atherosclerosis. The composition is capable of reducing human aortic endothelial inflammation caused by saturated fatty acids, for example, reducing the mRNA levels of interleukin-6 (IL-6) and matrix metalloproteinase-1 (MMP-1), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by saturated fatty acids, for example, increasing the expression of mitochondrial complexes I and III and mitochondrial metabolism-associated Foxo1.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for improving the function of aortic endothelial cells and an application thereof. Background technique [0002] Data show that 17,700 people die of cardiovascular disease every year in the world, accounting for 31% of the death toll. This data continues to increase steadily every year, and it is estimated that the death rate caused by cardiovascular disease will The rate is significantly higher than other diseases, in a leading position. Cardiovascular diseases mainly include cardiovascular and cerebrovascular diseases, such as myocardial infarction and cerebral infarction. Atherosclerosis is the pathological basis of cardiovascular diseases. [0003] The pathogenesis of atherosclerosis is very complex. It occurs in the vessel wall and is a chronic inflammatory response, plaque formation, and vascular endothelial cell damage. Factors leading to atheros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/77A61K31/795A61P9/10A61P29/00
CPCA61K31/19A61K31/77A61K31/795A61P9/10A61P29/00A61K2300/00A61K47/34A61K47/44
Inventor 刘健康柳絮云张添洋叶志盛叶鼎一
Owner XI AN JIAOTONG UNIV
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