Compound external medicine for treating chloasma and method for preparing compound external medicine

A technology for topical medicine and chloasma, applied in medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve the problem of poor treatment effect of chloasma

Inactive Publication Date: 2019-03-12
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that existing medicines have poor therapeutic effects on chloasma, the object of the invention is to propose a compound external medicine for treating chloasma and a preparation method thereof. The externa

Method used

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  • Compound external medicine for treating chloasma and method for preparing compound external medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A compound medicine for external use for the treatment of chloasma, comprising the following raw materials by weight:

[0048] 200g white pomegranate, 200g white aconite, 200g white tuckahoe, 200g trichosanthin, 30g arbutin, 30g resveratrol, 3g tranexamic acid, 30g L-vitamin C, 20g mandelic acid, 30g sodium hyaluronate, 3g butylene glycol , glycerin 10g, stearic acid 15g, glyceryl monostearate 4g, castor oil 20g, carbomer 30g, ethyl paraben 0.2g, sodium lauryl sulfate 2g, triethanolamine 2g, laurocapram 3g.

[0049] The preparation method of the compound external medicine for treating chloasma specifically comprises the following steps:

[0050] a. Weigh 200g of white pomegranate, 200g of white aconite, 200g of white poria cocos, and 200g of trichosanthes powder, grind them into granules, add them into 800ml of 75% ethanol, mix and stir evenly, and carry out heating, condensing and reflux. The heating temperature is 100°C. The time is 1h, then separate and filter the m...

Embodiment 2

[0058] Described a kind of compound medicine for external use of treating chloasma is made up of the raw material of following weight:

[0059] 300g white pomegranate, 300g white aconite, 300g white tuckahoe, 300g trichosanthin, 40g arbutin, 40g resveratrol, 4g tranexamic acid, 35g L-vitamin C, 30g mandelic acid, 40g sodium hyaluronate, 4g butylene glycol , glycerin 12.5g, stearic acid 20g, glyceryl monostearate 5g, castor oil 30g, carbomer 35g, ethylparaben 0.3g, sodium lauryl sulfate 3g, triethanolamine 3g, laurocapram 3.5 g.

[0060] The preparation method of the compound external medicine for treating chloasma specifically comprises the following steps:

[0061] a. Weigh 300g of white pomegranate, 300g of white aconite, 300g of white poria cocos, and 300g of trichosanthes powder, grind them into granules, add them into 900ml of 75% ethanol, mix and stir evenly, and carry out heating, condensing and reflux. The heating temperature is 100°C. The time is 1h, then separate a...

Embodiment 3

[0069] Described a kind of compound medicine for external use of treating chloasma is made up of the raw material of following weight:

[0070] 400g white pomegranate, 400g white aconite, 400g white tuckahoe, 400g trichosanthin, 50g arbutin, 50g resveratrol, 5g tranexamic acid, 40g L-vitamin C, 40g mandelic acid, 50g sodium hyaluronate, 5g butylene glycol , glycerin 15g, stearic acid 25g, glyceryl monostearate 6g, castor oil 40g, carbomer 40g, ethylparaben 0.4g, sodium lauryl sulfate 4g, triethanolamine 4g, laurocapram 4g.

[0071] The preparation method of the compound external medicine for treating chloasma specifically comprises the following steps:

[0072] a. Weigh 400g of white pomegranate, 400g of white aconite, 400g of white poria cocos, and 400g of trichosanthes powder, grind them into granules, and add them to 1000ml of 75% ethanol, mix and stir evenly, and carry out heating and condensing to reflux. The heating temperature is 100°C. The time is 1h, then separate an...

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Abstract

The invention discloses a compound external medicine for treating chloasma and a method for preparing the compound external medicine. The compound external medicine comprises, by weight, 200-400 g ofradix ampelopsis, 200-400 g of rhizoma typhonii, 200-400 g of white poria, 200-400 g of radix trichosanthis, 30-50 g of arbutin, 30-50 g of resveratrol, 3-5 g of tranexamic acid, 30-40 g of levorotaryvitamin C, 20-40 g of mandelic acid, 30-50 g of sodium hyaluronate, 3-5 g of butanediol, 10-15 g of glycerin, 15-25 g of stearic acid, 4-6 g of glycerin monostearate, 20-40 g of castor oil, 30-40 g of carbomer, 0.2-0.4 g of ethyl paraben, 2-4 g of sodium lauryl sulfate, 2-4 g of triethanolamine and 3-4 g of laurocapram. The compound external medicine and the method have the advantages that traditional Chinese medicines and western medicines are matched with one another to obtain the compound external medicine, accordingly, good curative effects can be realized by the compound external medicine, and the compound external medicine is free of optional irritation effects on skin.

Description

technical field [0001] The invention belongs to the technical field of medicine for external use, and in particular relates to a compound medicine for external use for treating chloasma and a preparation method thereof. Background technique [0002] Melasma, also known as liver spots, is mostly symmetrical butterfly-shaped distribution of yellow-brown pigmentation on the cheeks, periorbital, forehead and other parts. Chloasma is more common in women, and its onset may be related to pregnancy, long-term oral contraceptives, and menstrual disorders. Traditional Chinese medicine believes that chloasma is mostly caused by spleen deficiency and liver stagnation, internal emotional injury or damage to blood. Currently, there are hydroquinone cream, retinoic acid ointment, kojic acid cream and glucocorticoid ointment for external use in the treatment of chloasma, but most of them have unsatisfactory curative effect, single prescription or relatively large side effects. The main t...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P17/00A61K31/05A61K31/192A61K31/195A61K31/375A61K31/7034A61K31/728
CPCA61K9/0014A61K31/05A61K31/192A61K31/195A61K31/375A61K31/7034A61K31/728A61K36/076A61K36/428A61K36/87A61K36/888A61K2236/333A61K2236/51A61P17/00A61K2300/00
Inventor 尚智伟夏丽晔
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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