Method for catalytic synthesis of dicoumarin compound through lipases

A technology of dicoumarin and lipase, which is applied in the field of biocatalysis, can solve the problems of difficult catalyst preparation, difficult recycling, high reaction temperature, etc., and achieve the effects of wide application range of substrates, high catalytic activity, and simple operation
CN109456998AActive Publication Date: 2019-03-12NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2019-03-12

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Abstract

The invention discloses a method for catalytic synthesis of a dicoumarin compound through lipases. The method comprises the step: 4-hydroxycoumarin is adopted as a substrate, and subjected to a Knoevenagel-Michael cascade reaction through lipase catalyzing to generate the dicoumarin compound with a compound in the formula II. The dicoumarin compound can be used for treating thrombus, resisting HIV, and treating asthma, skin cancer and snake venom, and can further be used for antimicrobial treatment of certain staphylococcus aureus and staphylococcus epidermidis and preparing of analytical reagents; and according to the method, reacting conditions are mild, aftertreatment is easy, the substrate is widespread, a catalyst can be recycled, and the method is an economical and environment-friendly new method for synthesizing the dicoumarin compound.
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Description

technical field

[0001] The invention belongs to the technical field of biocatalysis, and in particular relates to a method for synthesizing dicoumarin compounds by lipase catalyzing the Knoevenagel-Michael cascade reaction of aromatic aldehydes and 4-hydroxycoumarin in a pure water phase. Background technique

[0002] Dicoumarins are widely used because of their active pharmacological and biological activities. It can be used as a vitamin K antagonist, anticoagulant, and used to treat thrombosis; it has antibacterial activity against certain Staphylococcus aureus and Staphylococcus epidermidis, and can be used as an anti-inflammatory and antipyretic; it can be used to treat HIV, asthma, skin cancer and snake venom can also be used to make analytical reagents. Dicoumarins are generally obtained from 4-hydroxycoumarin and aromatic aldehydes through Knoevenagel condensation-Michael addition. At present, there are various methods for synthesizing dicoumarin compounds. For exa...

Claims

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