Preparation method of metal doped fluorescent carbon quantum dot

A technology of carbon quantum dots and metal doping, which is applied in fluorescence/phosphorescence, chemical instruments and methods, preparations for in vivo experiments, etc., and can solve problems such as strong application limitations, less metal doping, and high cytotoxicity , to achieve high doping rate and yield, simple synthesis method and wide application range

Active Publication Date: 2019-03-15
WUHAN INSTITUTE OF TECHNOLOGY
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  • Claims
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Problems solved by technology

[0003] In view of this, the present invention aims to propose a method for preparing metal-doped fluorescent carbon quantum dots to solve the problem of low metal doping, low yield, strong application limitations, and problems in existing metal-doped carbon quantum dots. The issue of greater cytotoxicity

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  • Preparation method of metal doped fluorescent carbon quantum dot
  • Preparation method of metal doped fluorescent carbon quantum dot
  • Preparation method of metal doped fluorescent carbon quantum dot

Examples

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Embodiment 1

[0039] A method for preparing metal-doped fluorescent carbon quantum dots, which specifically comprises the following steps:

[0040] 1) Dissolve 10 mg of tetraphenylmanganese porphyrin (MnTPP) in 4 mL of tetrahydrofuran to obtain liquid A. At this time, the mass concentration of tetraphenyl manganese porphyrin (MnTPP) in THF is 2.5 mg / mL;

[0041] 2) Dissolve 2 g of citric acid in 40 mL of water to obtain liquid B. At this time, the mass concentration of citric acid in water is 50 mg / mL;

[0042] 3) Mix liquid A and liquid B, and perform ultrasonic dispersion to obtain mixed liquid C, wherein the volume ratio of tetrahydrofuran in liquid A to water in liquid B is 1:10, and the dispersion time of ultrasonic dispersion is 20 minutes;

[0043] 4) Put the mixed solution C in an oil bath at 180°C for heating in an oil bath. After the mixed solution C becomes viscous, add 3 mL of water and continue the reaction. Repeat this process 5 times to obtain the reaction solution D;

[004...

Embodiment 2

[0046] The difference between this example and Example 1 is that the metalloporphyrin compound is tetraphenyl zinc porphyrin (ZnTPP).

Embodiment 3

[0048] The difference between this example and Example 1 is that the metalloporphyrin compound is tetraphenylcopper porphyrin (CuTPP).

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Abstract

The invention provides a preparation method for of a metal-doped fluorescent carbon quantum dot. The preparation method comprises the following steps: 1) dissolving a metal porphyrin compound in tetrahydrofuran to obtain liquid A; 2) dissolving a polycarboxylic acid compound in water to obtain liquid B; 3) mixing the liquid A and the liquid B and carrying out ultrasonic dispersion to obtain mixedliquid C; 4) heating the mixed liquid C in oil bath, after the mixed liquid C is viscous, adding water to continue the reaction, and repeating the process for multiple times to obtain reaction liquidD; and 5) adding water to the reaction liquid D and adjusting the pH by using an alkaline reagent, dialyzing the supernatant of the reaction liquid D, collecting the aqueous solution obtained by dialysis, and lyophilizing the aqueous solution to obtain the metal doped fluorescent carbon quantum dot. According to the preparation method, the poorly water-soluble metal porphyrin compound is coated bythe water-soluble polycarboxylic acid compound under a hydrothermal condition, so that the metal doped fluorescent carbon quantum dot is high in metal doping rate and high yield, small in toxicity and wide in application range.

Description

technical field [0001] The invention relates to the technical field of nano-luminescent materials, in particular to a method for preparing metal-doped fluorescent carbon quantum dots. Background technique [0002] With the rapid development of nanotechnology, new nano-fluorescent materials mainly include two categories: semiconductor quantum dots and carbon quantum dots, which are widely used in biological imaging because of their simple preparation, photobleaching resistance, high photosensitivity and wide dynamic range. , medical diagnosis, analytical testing and other fields. Among them, carbon quantum dots have attracted widespread attention due to their low toxicity and excellent biocompatibility. The current metal-doped carbon quantum dots are obtained by adding citric acid, organic amines, and inorganic metal ions by the hydrothermal method. Quantum dots have disadvantages such as strong application limitations and high cytotoxicity. Therefore, it is of great pract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65A61K49/00G01N21/64B82Y20/00B82Y30/00
CPCA61K49/0017B82Y20/00B82Y30/00C09K11/65G01N21/64
Inventor 吴风收乐亮亮孙琦王凯
Owner WUHAN INSTITUTE OF TECHNOLOGY
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