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Porous scaffold based on three-dimensional inkjet printing technology and preparation method of porous scaffold

A porous stent and inkjet printing technology, which is applied in the directions of additive manufacturing, processing and manufacturing, and manufacturing tools, can solve the problems of low 3D inkjet printing accuracy and difficulty in printing models, and achieve the effect of economical convenience and high biological safety.

Active Publication Date: 2019-03-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for biological 3D printing, because it is necessary to ensure the biocompatibility of the printed scaffold, many material curing methods are difficult to apply, which leads to the low accuracy of 3D inkjet printing, and it is difficult to print more complex models

Method used

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  • Porous scaffold based on three-dimensional inkjet printing technology and preparation method of porous scaffold
  • Porous scaffold based on three-dimensional inkjet printing technology and preparation method of porous scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Configure calcium phosphate bioactive ceramic printing ink;

[0037] Calcium phosphate powder, polyvinyl alcohol (PVB, Mn=70000-90000) and ethanol (Sigma) were thoroughly mixed in a ratio of 3.6:32:32 to prepare calcium phosphate-based bioactive ceramic printing ink.

[0038] (2) Configure support medium:

[0039] Mix the agar and up water at a ratio of 1:99 and heat to 90°C. After the agar is fully dissolved, lower the temperature of the agar solution to room temperature.

[0040] (3) Three-dimensional inkjet printing technology (3DP) was used to prepare the required scaffolds. During the printing process, the bottom of the container loaded with agar was guaranteed to be the printing platform, and the printing nozzle was always at the level of the agar liquid level.

[0041] (4) Slowly heat the agar colloid embedding the printing scaffold to 90°C, and take out the scaffold after the agar is completely melted.

[0042] The printing ink of the above-mentioned embod...

Embodiment 2

[0044] (1) Configure sodium alginate biohydrogel printing ink

[0045] Fully mix sodium alginate powder and up water at a ratio of 6:94, stir to fully dissolve sodium alginate to make printing ink.

[0046] (2) Configure support medium:

[0047] Mix agar, calcium chloride and up water in a ratio of 1:9:90 and heat to 90°C. After the agar is fully dissolved, lower the temperature of the agar solution to room temperature.

[0048] (3) Three-dimensional inkjet printing technology (3DP) was used to prepare sodium alginate scaffolds. During the printing process, the bottom of the container loaded with agar was guaranteed to be the printing platform, and the printing nozzle was always at the height of the agar liquid level.

[0049] (4) Slowly heat the agar colloid embedding the printing scaffold to 90°C, and take out the scaffold after the agar is completely melted.

[0050] In the preparation process of the above examples, the printing ink is sodium alginate solution, which is a v...

Embodiment 3

[0052] (1) Configure gelatin biohydrogel printing ink

[0053] Mix the gelatin powder and up water at a ratio of 10:90, and stir to fully dissolve the gelatin to make printing ink.

[0054] (2) Configure support medium:

[0055] Mix agar, glutaraldehyde and up water in a ratio of 1:2:97 and heat to 90°C. After the agar is fully dissolved, lower the temperature of the agar solution to room temperature.

[0056] (3) Three-dimensional inkjet printing technology (3DP) was used to prepare the gelatin scaffold. During the printing process, the bottom of the container loaded with agar was guaranteed to be the printing platform, and the printing nozzle was always at the level of the agar liquid level.

[0057] (4) Slowly heat the agar colloid embedding the printing scaffold to 90°C, and take out the scaffold after the agar is completely melted.

[0058] In this embodiment, the printing ink is a gelatin solution, which is a very common raw material for a scaffold, and a three-dimensi...

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Abstract

The invention discloses a porous scaffold based on three-dimensional inkjet printing technology and a preparation method of the porous scaffold, and belongs to the field of biomedical materials. According to the porous scaffold based on the three-dimensional inkjet printing technology and the preparation method of the porous scaffold, a three-dimensional scaffold body is printed in a medium with asupporting function, the supporting medium can support the scaffold body, smooth printing of the scaffold body is ensured, and a curing factor can further be additionally added to the supporting medium, so that rapid forming of the printed scaffold body is facilitated. The supporting medium is additionally arranged on a printing platform on the basis of not changing original three-dimensional inkjet printing equipment, the printed material is enabled to be embedded in a supportive agaropectin body, and in this way, printing of the material with poor forming performance can be achieved. Agar is heated and dissolved after printing is completed, and the printed scaffold body can be obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a biomaterial with poor molding ability and a preparation method thereof. technical background [0002] The repair and reconstruction of missing or dysfunctional tissues and organs is still a major problem in biomedicine. About tens of millions of people around the world suffer from various forms of trauma every year, and hundreds of thousands of people are eager to undergo various organ transplants. As an indispensable clinical treatment, organ transplantation mainly adopts the injury treatment mode, and it is difficult to meet the needs of clinical treatment due to the limitations of organ sources, ethics, and immune rejection of the body. The birth and development of engineering has made it possible for damaged tissues to grow back. In the application of tissue engineering, three-dimensional scaffolds play a vital role as the carrier of cells. After continuous ...

Claims

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Application Information

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IPC IPC(8): B29C64/10B29C64/314B29C64/40B33Y10/00B33Y40/00A61L27/56A61L27/26A61L27/22A61L27/20A61L27/16A61L27/12
CPCA61L27/12A61L27/16A61L27/20A61L27/222A61L27/26A61L27/56B29C64/10B29C64/314B29C64/40B33Y10/00B33Y40/00C08L5/04C08L29/04C08L89/00
Inventor 张勃庆胡亦清姚云茜蔡武峰鲍旻玥王璟周长春王科锋
Owner SICHUAN UNIV
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