Bioactive Glass Nanoparticles Physiological Environment Stability Modification Method and Biomedical Application

A technology of bioactive glass and physiological environment, applied in the direction of organic active ingredients, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor biocompatibility and complicated steps of nanoparticles, and achieve Modification technology is simple and easy to prevent agglomeration and precipitation, long-term stable degradability and biological activity

Active Publication Date: 2020-10-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the reported nanoparticle modification methods have complicated steps and the obtained modified nanoparticles have poor biocompatibility.

Method used

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  • Bioactive Glass Nanoparticles Physiological Environment Stability Modification Method and Biomedical Application
  • Bioactive Glass Nanoparticles Physiological Environment Stability Modification Method and Biomedical Application
  • Bioactive Glass Nanoparticles Physiological Environment Stability Modification Method and Biomedical Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Preparation of bioactive glass nanoparticles: using hexadecylpyridinium bromide as a template, bioactive glass nanoparticles were synthesized by sol-gel method combined with template method;

[0035] (2) Preparation of modified system: Dissolve bisphosphonate sodium alendronate in sodium acetate buffer solution with pH = 4, wait until alendronate sodium is completely dissolved, stir gently at room temperature for 0.5h, bisphosphonate The concentration of alendronate sodium is 20mg / mL;

[0036] (3) Modification process: the bioactive glass nanoparticles were added to the sodium acetate solution of alendronate sodium, the concentration of the bioactive glass nanoparticles was 10 mg / mL, 300W ultrasonic for 30min, and then gently stirred at room temperature for 24h;

[0037] (4) Purification and drying: the modified bioactive glass nanoparticle solution was centrifuged at a speed of 9000 rpm for 3 minutes, and washed 3 times with deionized water to obtain bioactive glas...

Embodiment 2

[0040] (1) Preparation of bioactive glass nanoparticles: using hexadecylpyridinium bromide as a template, bioactive glass nanoparticles were synthesized by sol-gel method combined with template method;

[0041] (2) Preparation of modified system: dissolve fosfomycin sodium in sodium acetate buffer solution with pH=4, wait for the fosfomycin sodium to completely dissolve, stir gently at room temperature for 0.5h, the concentration of fosfomycin sodium is 40mg / mL;

[0042] (3) Modification process: add bioactive glass nanoparticles into the sodium acetate solution of fosfomycin sodium, the concentration of bioactive glass nanoparticles is 10mg / mL, 300W ultrasonic for 30min, then gently stir at room temperature for 24h;

[0043] (4) Purification and drying: Centrifuge the modified bioactive glass nanoparticles at a speed of 9000 rpm for 3 minutes, wash with deionized water 3 times, and obtain bioactive glass nanoparticles with physiological environmental stability;

[0044] (5)...

Embodiment 3

[0046] (1) Preparation of bioactive glass nanoparticles: using hexadecylpyridinium bromide as a template, bioactive glass nanoparticles were synthesized by sol-gel method combined with template method;

[0047] (2) Preparation of modified system: Dissolve sodium glycerophosphate in deionized water, wait until sodium glycerophosphate is completely dissolved, stir gently at room temperature for 0.5h, the concentration of sodium glycerophosphate is 3mg / mL;

[0048] (3) Modification process: add bioactive glass nanoparticles into the aqueous solution of sodium glycerophosphate, the concentration of bioactive glass nanoparticles is 1mg / mL, 300W ultrasonic for 30min, then gently stir at room temperature for 1h;

[0049] (4) Purification and drying: Centrifuge the modified bioactive glass nanoparticles at a speed of 9000 rpm for 3 minutes, wash with deionized water 3 times, and obtain bioactive glass nanoparticles with physiological environmental stability;

[0050] (5) Biomedical ap...

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Abstract

The invention relates to a method for modifying the physiological environmental stability of biological active glass nanoparticles and biomedical application. The method comprises the steps of dissolving a modifying agent into deionized water or buffer liquid, mildly stirring until the hydrophilic modifying agent containing phosphate is dissolved, adding the biological active glass nanoparticles to generate modification, and carrying out centrifugal washing and freeze-drying, so as to obtain a product. The modification technique is simple, feasible and mild in reaction condition; the biological active glass nanoparticles are modified by virtue of the ion action force among anionic groups such as calcium ions and phosphate radicals in the modifying agent and the absorption effect of the biological active glass nanoparticles to rich proteins in serum for the first time, so that the hydrophily and stability of the biological active glass nanoparticles in different dispersion systems are improved, and the modified biological active glass nanoparticles have good physiological environmental stability, are capable of effectively inhibiting the growth and proliferation of cancer cells andhave huge utilization potentialities in the biomedical fields such as the restoration and reconstruction of tissues and the treatment of cancers.

Description

technical field [0001] The invention relates to a modification technology of bioactive glass nanoparticles used for drug delivery, cancer treatment, tissue repair and regeneration, in particular to a method for modifying the physiological environment stability of bioactive glass nanoparticles and biomedical applications. Background technique [0002] Bioactive glass is a representative silicate-based biomaterial. Due to its good biocompatibility and osseointegration ability, bioactive glass is widely used in clinical bone tissue repair and regeneration. The most common bioactive glass is made of SiO 2 -CaO-P 2 o 5 Composition of amorphous silicates, where SiO 2 and P 2 o 5 form the base network, SiO 4 The tetrahedrons are connected by bridging oxygen bonds (Si-O-Si), and metal ions act as network modifiers through non-bridging oxygen bonds (Si-O-M + ) form into it. Due to the presence of non-bridged oxygen bonds, bioactive glasses exhibit better biodegradability than...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K47/04A61K47/24A61K47/46A61K31/704A61P35/00
CPCA61K31/704A61K47/02A61K47/24A61K47/46A61P35/00
Inventor 雷波薛语萌陈密
Owner XI AN JIAOTONG UNIV
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