Bioactive Glass Nanoparticles Physiological Environment Stability Modification Method and Biomedical Application

Abstract

The invention relates to a method for modifying the physiological environmental stability of biological active glass nanoparticles and biomedical application. The method comprises the steps of dissolving a modifying agent into deionized water or buffer liquid, mildly stirring until the hydrophilic modifying agent containing phosphate is dissolved, adding the biological active glass nanoparticles to generate modification, and carrying out centrifugal washing and freeze-drying, so as to obtain a product. The modification technique is simple, feasible and mild in reaction condition; the biological active glass nanoparticles are modified by virtue of the ion action force among anionic groups such as calcium ions and phosphate radicals in the modifying agent and the absorption effect of the biological active glass nanoparticles to rich proteins in serum for the first time, so that the hydrophily and stability of the biological active glass nanoparticles in different dispersion systems are improved, and the modified biological active glass nanoparticles have good physiological environmental stability, are capable of effectively inhibiting the growth and proliferation of cancer cells andhave huge utilization potentialities in the biomedical fields such as the restoration and reconstruction of tissues and the treatment of cancers.

Description

technical field [0001] The invention relates to a modification technology of bioactive glass nanoparticles used for drug delivery, cancer treatment, tissue repair and regeneration, in particular to a method for modifying the physiological environment stability of bioactive glass nanoparticles and biomedical applications. Background technique [0002] Bioactive glass is a representative silicate-based biomaterial. Due to its good biocompatibility and osseointegration ability, bioactive glass is widely used in clinical bone tissue repair and regeneration. The most common bioactive glass is made of SiO 2 -CaO-P 2 o 5 Composition of amorphous silicates, where SiO 2 and P 2 o 5 form the base network, SiO 4 The tetrahedrons are connected by bridging oxygen bonds (Si-O-Si), and metal ions act as network modifiers through non-bridging oxygen bonds (Si-O-M + ) form into it. Due to the presence of non-bridged oxygen bonds, bioactive glasses exhibit better biodegradability than...

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Problems solved by technology

However, most of the reported nanoparticle modification methods have complicated steps and the obtained modified nanoparticles have poor biocompatibility.

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