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Composition of externally applied drug for treating intraluminal mucosal inflammation, externally applied drug, preparation method and application of externally applied drug

A kind of external medicine, technology of composition

Pending Publication Date: 2019-03-29
余浚龙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the general gynecological Chinese patent medicines have the effect of clearing away heat and detoxification, can play a better effect of regulating endocrine, and can adjust women's physique, but the effect is slow and the pertinence is not strong. Drugs should not be used as the main therapeutic drugs, otherwise the pathogens that cause inflammation will take the opportunity to spread and develop, thus aggravating the condition

Method used

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  • Composition of externally applied drug for treating intraluminal mucosal inflammation, externally applied drug, preparation method and application of externally applied drug
  • Composition of externally applied drug for treating intraluminal mucosal inflammation, externally applied drug, preparation method and application of externally applied drug
  • Composition of externally applied drug for treating intraluminal mucosal inflammation, externally applied drug, preparation method and application of externally applied drug

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Effect test

preparation example Construction

[0028] The preparation method of the external medicine for treating inner cavity mucous membrane inflammation is prepared from the above-mentioned composition of the external medicine for treating inner cavity mucous membrane inflammation. The preparation method comprises: injecting ozone into a closed container containing vegetable oil or / and deep-sea fish oil to obtain The first ozone gel with an ozone concentration of 100-130g / L.

[0029] The ozone is passed into the vegetable oil or / and deep-sea fish oil, and the vegetable oil or / and deep-sea fish oil is subjected to saturated ozonation, that is, the vegetable oil or / and deep-sea fish oil cannot recombine ozone.

[0030] In the process of gradually introducing ozone into vegetable oil or / and deep-sea fish oil, ozone can gradually react with unsaturated fatty acids in vegetable oil and deep-sea fish oil, so that ozone molecules are gradually coated in vegetable oil and deep-sea fish oil molecules, and vegetable oil and deep-...

Embodiment 1

[0047] The content of each component of the first ozone gel in the external medicine for the treatment of intraluminal mucosal inflammation is shown in Table 1:

[0048] The content of each component of the first ozone gel of table 1

[0049]

[0050] Pass the ozone of each component content in Table 1 into the vegetable oil of each component content to obtain the first ozone gel, detect the bacteriostatic rate of the first ozone gel that embodiment 1-5 and comparative example 1-3 obtain and acid value.

[0051] Among them, the method for measuring the antibacterial rate is: transfer Escherichia coli, Staphylococcus aureus, and Candida albicans stored in a refrigerator at 4°C to a fresh nutrient medium, culture at 37°C for 18-24h, and use 10ml of bacterial lawn Wash the sterilized physiological saline twice into the Erlenmeyer flask equipped with glass beads, put it on a shaker at 200r / min for 10min, and adjust the concentration of the bacterial suspension to 106CFU / ml.

...

Embodiment 2

[0059] Compared with embodiment 2, embodiment 3 and embodiment 4, sesame oil and camellia oil are used in combination, and the bactericidal effect of various fungi and sesame oil have little influence on the bactericidal effect of various fungi. Example 3 Compared with Example 5, deep-sea fish oil is used to prepare the first ozone gel, and its bactericidal effect is slightly lower than that of camellia oil, but it is equivalent to that of sesame oil, and higher than that of olive oil .

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Abstract

The invention provides a composition of an externally applied drug for treating intraluminal mucosal inflammation, the externally applied drug, a preparation method and application of the externally applied drug, and belongs to the technical field of drugs for intraluminal mucosal inflammation. The composition of the externally applied drug for treating intraluminal mucosal inflammation comprisesa first ozone gel which comprises ozone, vegetable oil or / and deep sea fish oil, and the concentration of ozone in the first ozone gel is 100 to 130 g / L. The externally applied drug for treating intraluminal mucosal inflammation is prepared from the composition, and the preparation method comprises the step of introducing ozone into the vegetable oil or / and deep sea fish oil to obtain the first ozone gel with the concentration of ozone of 100 to 130 g / L. The externally applied drug for treating intraluminal mucosal inflammation prepared from the composition with the preparation method can effectively treat intraluminal mucosal inflammation, such as, gynecological inflammation, such as vaginitis, cervicitis and intrauterine inflammation, and can also used for treating rhinitis, stomatitis,intestinal inflammation and other inflammation, and the externally applied drug is good in treatment effect and takes effect quickly.

Description

technical field [0001] The present application relates to the technical field of medication for intraluminal mucosal inflammation, and specifically relates to a composition for external use for treating intraluminal mucosal inflammation, an external drug, its preparation method and its application. Background technique [0002] Diseases of the female reproductive system are gynecological diseases. Gynecological diseases are common and frequently-occurring diseases of women, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, and ovarian diseases. Among them, vaginitis is mostly inflammation caused by pathogens such as bacteria and fungi, and most of them are treated with antibiotics, which have certain drug resistance and side effects. Most of the general gynecological Chinese patent medicines have the effect of clearing away heat and detoxification, can play a good role in regulating endocrine, and can adjust women's physique, but the eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/06A61K36/534A61K36/54A61K36/82A61K47/44A61P1/00A61P1/02A61P11/02A61P15/00A61P31/04A61P31/10
CPCA61K9/0034A61K9/06A61K33/00A61K36/534A61K36/54A61K36/82A61K47/44A61P1/00A61P1/02A61P11/02A61P15/00A61P31/04A61P31/10A61K2300/00
Inventor 余浚龙唐数青
Owner 余浚龙
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