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Heat sensitive nanofiber as well as preparation method, drug carrying heat sensitive nanofiber and preparation method

A nanofiber, heat-sensitive technology, applied in fiber types, fiber treatment, pharmaceutical formulations, etc., to achieve the effects of simple process, reduced preparation cost, and convenient operation

Inactive Publication Date: 2019-03-29
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the preparation of nanofibers by electrospinning has been widely used in drug delivery systems, but the current drug delivery systems obtained by electrospinning generally disperse the drugs on or near the surface of the fibers, resulting in their in vivo effects. drug burst phenomenon

Method used

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  • Heat sensitive nanofiber as well as preparation method, drug carrying heat sensitive nanofiber and preparation method
  • Heat sensitive nanofiber as well as preparation method, drug carrying heat sensitive nanofiber and preparation method
  • Heat sensitive nanofiber as well as preparation method, drug carrying heat sensitive nanofiber and preparation method

Examples

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preparation example Construction

[0032] According to a second aspect of the present invention, the present invention provides a method for preparing heat-sensitive nanofibers, comprising the steps of:

[0033] Firstly, the photoinitiator is adsorbed on the surface of the PCL nanofiber to obtain the PCL nanofiber with the photoinitiator adsorbed on the surface, and then the PCL nanofiber with the photoinitiator adsorbed on the surface is immersed in the mixed solution of PEGDMA oligomer and NIPAAm, and finally the ultraviolet Under light irradiation, the PEGDMA oligomer and NIPAAm are in-situ polymerized on the surface of the PCL nanofibers to obtain thermosensitive nanofibers with the PCL nanofibers as the core and the PEG-PNIPAAm as the shell.

[0034] In the present invention, PEGDMA refers to polyethylene glycol dimethacrylate, and NIPAAm refers to N-isopropylamide.

[0035] The preparation method of heat-sensitive nanofiber provided by the invention, by absorbing photoinitiator on the surface of PCL nanof...

Embodiment 1

[0076] This embodiment provides a drug-loaded thermosensitive nanofiber, which is prepared according to the following steps:

[0077] (1) Configure the mixed solution of salicylic acid (SA) and PCL, wherein the solvent is a mixed solution of DCM and DMF, the mass ratio of the two is 7:3, the volume concentration of SA is 3%, and the mass concentration of PCL 10%;

[0078] (2) The mixed solution of SA and PCL is obtained drug-loaded PCL nanofiber by electrospinning;

[0079] (3) Immerse the drug-loaded PCL nanofibers in a benzophenone solution with a mass concentration of 20%, take them out after 5 minutes, and dry them in vacuum to obtain drug-loaded PCL nanofibers adsorbed with benzophenone;

[0080] (4) The drug-loaded PCL nanofibers adsorbed with benzophenone are immersed in a mixed solution of PEGDMA oligomers and NIPAAm, wherein the mass ratio of PEGDMA oligomers and NIPAAm is 3:5, and under ultraviolet light irradiation, PEGDMA oligomers and NIPAAm were in-situ polymer...

Embodiment 2

[0082] This example provides a drug-loaded thermosensitive nanofiber. The difference between this example and the preparation method of Example 1 is that in step (3), the mass concentration of the benzophenone solution is 10%.

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Abstract

The invention provides a heat sensitive nanofiber as well as preparation method, a preparation method, a drug carrying heat sensitive nanofiber and a preparation method, and relates to the technical field of nanofibers. The heat sensitive nanofiber comprises a PCL nanofiber, wherein the PCL nanofiber is coated by a PEG-PNIPAAm shell layer. Technical problems that a medicine controlled delivery system prepared according to the conventional electrostatic spinning method has a burst medicine release phenomenon in bodies as medicines are dispersed on the surface of a fiber or close to the surfaceof the fiber can be alleviated; the heat sensitive nanofiber provided according to the invention adopts a PCL nanofiber as a core layer, medicines are covered in the core layer by using the PEG-PNIPAAm shell layer, an external heat sensitive polymer shell layer is used as a shield, diffusion routes are provided for continuous release of the medicines, the purpose of regulating and controlling medicine release according to temperatures is achieved, and the heat sensitive nanofiber has wide application prospects in the field of biomedicines.

Description

technical field [0001] The invention relates to the technical field of nanofibers, in particular to a thermosensitive nanofiber and a preparation method thereof, and a drug-loaded thermosensitive nanofiber and a preparation method thereof. Background technique [0002] Recently, controlled drug delivery systems have been extensively studied to improve the pharmacology and therapeutic efficacy of commercial drugs. For rate- or time-controlled delivery systems, the drug release profile should maximize effective drug delivery and reduce potential side effects of the drug in clinical therapy. [0003] At present, the preparation of nanofibers by electrospinning has been widely used in drug delivery systems, but the current drug delivery systems obtained by electrospinning generally disperse the drugs on or near the surface of the fibers, resulting in their in vivo effects. Drug release phenomenon. [0004] In view of this, the present invention is proposed. Contents of the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/285D06M15/263A61K9/00A61K47/34A61K47/22D06M101/32
CPCA61K9/0092A61K47/22A61K47/34D06M15/263D06M15/285D06M2101/32
Inventor 于晖黄文俊蔡洁李英毅朱吉昌曾健豪郭永诗黄琪帏邹捷
Owner WUYI UNIV