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Composition with efficacy for treating conjunctivitis and preparation method thereof

A composition and technology of conjunctivitis, applied in the field of composition and its preparation with the efficacy of treating ophthalmic diseases, can solve the problems of easy drug resistance, eye damage, low curative effect, etc., and achieve drug resistance, easy The effect of low absorption and production cost

Active Publication Date: 2021-06-01
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for the treatment of ophthalmic diseases. Although they can temporarily improve eye health problems, after a period of use, various side effects will appear, which may cause greater damage to the eyes; or easily develop resistance. Drug properties, so that the curative effect is low or even ineffective

Method used

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  • Composition with efficacy for treating conjunctivitis and preparation method thereof
  • Composition with efficacy for treating conjunctivitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The preparation method of the second composition comprises steps:

[0022] Pulverize Polygonatum and Angelica to obtain a mixed powder; then put it into water, soak at 62-66°C for 4-5 hours, then ultrasonically extract for 40-50 minutes, filter after extraction, and collect the first filtrate and the first filter residue respectively; among them, the water The mass is 10-14 times the total mass of Polygonatum and Angelica; the power of ultrasonic extraction is 250-300W, and the temperature of ultrasonic extraction is 55-60°C;

[0023] Put the honeysuckle flower in an aqueous ethanol solution with a volume fraction of 26% to 30%, adjust the pH value to 8.6 to 8.8, then reflux for extraction for 70 to 80 minutes, filter after the extraction, and recover the collected filtrate with ethanol to obtain a second filtrate; Wherein, the mass ratio of honeysuckle and ethanol aqueous solution is 1: (20~30);

[0024] Put other remaining raw material components and the first filter...

Embodiment 1

[0030] This example provides a composition with the effect of treating ophthalmic diseases, including the first composition and the second composition with a mass ratio of 1:0.26: the components of the first composition include the composition with a mass ratio of 1:0.14:0.06 Tofacitinib, methylcellulose and glucose chlorhexidine; the second composition is prepared by using honeysuckle, lotus leaf, sealwort, angelica dahurica, almond and angelica with a mass ratio of 1:0.25:1.2:0.55:0.3:2.9 become;

[0031] The preparation method of the second composition comprises steps:

[0032] Pulverize Polygonatum and Angelica to obtain mixed powder; then put it into water, soak at 64°C for 4.5 hours, then ultrasonically extract for 45 minutes, filter after extraction, and collect the first filtrate and the first filter residue respectively; among them, the quality of water is Polygonatum and Angelica The total mass of 12 times; the power of ultrasonic extraction is 280W, and the temperatu...

Embodiment 2

[0039] This embodiment provides a composition with the effect of treating ophthalmic diseases, including the first composition and the second composition with a mass ratio of 1:0.24: the components of the first composition include the composition with a mass ratio of 1:0.12:0.05 Tofacitinib, methylcellulose and glucose chlorhexidine; the second composition is prepared by using honeysuckle, lotus leaf, sealwort, angelica dahurica, almond and angelica with a mass ratio of 1:0.2:1.0:0.5:0.2:2.8 become;

[0040] The preparation method of the second composition comprises steps:

[0041] Pulverize Polygonatum and Angelica to obtain mixed powder; then put it into water, soak at 62°C for 4 hours, then ultrasonically extract for 40 minutes, filter after extraction, and collect the first filtrate and first filter residue respectively; among them, the quality of water is that of Polygonatum and Angelica. 10 times the total mass; the power of ultrasonic extraction is 250W, and the temper...

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Abstract

The present invention relates to a composition containing tofacitinib that has the effect of treating ophthalmic diseases and a preparation method thereof. The composition having the effect of treating ophthalmic diseases includes a first composition and a second composition: the components of the first composition Including: tofacitinib, methylcellulose and glucose chlorhexidine; the second composition is prepared by using honeysuckle, lotus leaf, sealwort, angelica dahurica, almond and angelica; wherein, the first composition and the second composition The mass ratio is 1:(0.24~0.28). Based on years of clinical experience in the treatment of ophthalmic diseases and combined with modern pharmaceutical achievements, the present invention uses honeysuckle, lotus leaf, sealwort and angelica with different medicinal properties to carry out scientific compatibility with tofacitinib, etc., and the prepared composition has the ability to treat ophthalmic diseases. The effect is obvious, the effect is quick, the symptoms and root causes are treated, there will be no allergies or other reactions, and no side effects; it is not easy to produce drug resistance, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a composition containing tofacitinib and capable of treating ophthalmic diseases and a preparation method thereof. Background technique [0002] The eye is a very important organ of the human body, and it is also one of the most frequently used organs of the human body. Therefore, if you do not pay attention to protection, eye diseases are prone to occur. Local bacterial infection of the eye, including conjunctivitis, keratitis, corneal ulcer, iritis, eye trauma, chemical injury, infection after eye surgery, etc. Most of the pathogenic bacteria are Pseudomonas aeruginosa and Gram-positive cocci, Such as Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus aureus and Neisseria gonorrhoeae, among which Staphylococcus epidermidis is the first. The symptoms of conjunctivitis are mostly acute onset, and one or both eyes may be affected. In the early s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K36/8969A61P27/02A61K31/717A61K31/155
CPCA61K31/155A61K31/519A61K31/717A61K36/232A61K36/355A61K36/62A61K36/736A61K36/8969A61K2236/331A61K2236/333A61K2236/51A61P27/02A61K2300/00
Inventor 梁丹苏文如李英琦
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV