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Preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions

A composite hydrogel and wound healing technology, applied in bandages, medical science and other directions, can solve the problems of not being able to take into account the functions of antibacterial and promoting wound healing at the same time, and the single role of wound dressings, achieving high clinical and market application potential, Promotes wound healing and has a strong practical effect

Active Publication Date: 2021-01-29
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of the above-mentioned prior art, the present invention provides a preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions, which is used as a wound dressing to solve Existing wound dressings have a single function and cannot take into account the functions of antibacterial and wound healing at the same time

Method used

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  • Preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions
  • Preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions
  • Preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] In this example, the preparation of thermally induced irreversible composite hydrogel is carried out as follows:

[0026] Step 1: Dissolve 15g of polyethylene glycol (Mw=4000) and 1.8g of triethylamine in 150mL of dichloromethane. After argon protection, add 3.4g of 2-bromoisobutyryl bromide, and dissolve the solution in Stir at 0°C for 1 hour, then at room temperature for another 72 hours, the resulting product is separated by aluminum column (eluent is tetrahydrofuran), dialyzed (regenerated cellulose dialysis bag MWCO: 1000D), freeze-dried (lyophilized temperature -60 ℃), obtain atom transfer radical polymerization initiator;

[0027] Step 2: Dissolve 0.2 g of the atom transfer radical polymerization initiator obtained in step 1 in 6 mL of isopropanol / water mixed solvent, put it into a polymerization bottle, and then add 2.5 g of N-isopropylacrylamide, 0.16 g of butyl acrylate and 28.6 mg of cuprous chloride were fully dissolved, protected by argon, and after three ...

Embodiment 2

[0048] In this example, thermally induced irreversible composite hydrogels were prepared according to the following steps:

[0049] Step 1: Dissolve 10g of polyethylene glycol (Mw=4000) and 1g of triethylamine in 150mL of dichloromethane. After passing through argon for protection, add 2g of 2-bromoisobutyryl bromide, and place the solution at 0°C Stirring at low temperature for 1 hour, and then stirring at room temperature for 72 hours, the resulting product was separated by aluminum column (eluent is tetrahydrofuran), dialyzed (regenerated cellulose dialysis bag MWCO: 1000D), lyophilized (lyophilized temperature -60 ° C) Afterwards, obtain atom transfer radical polymerization initiator;

[0050] Step 2: Dissolve 0.2 g of the atom transfer radical polymerization initiator obtained in step 1 in 6 mL of isopropanol / water mixed solvent, put it into a polymerization bottle, and then add 2.5 g of N-propylacrylamide, 0.16g of hydroxyethyl methacrylate and 28.6mg of cuprous chlorid...

Embodiment 3

[0057] In this example, thermally induced irreversible composite hydrogels were prepared according to the following steps:

[0058] Step 1: Dissolve 15g of polyethylene glycol (Mw=4000) and 1.8g of triethylamine in 150mL of dichloromethane. After argon protection, add 3.4g of 2-bromoisobutyryl bromide, and dissolve the solution in Stir at 0°C for 1 hour, then at room temperature for another 72 hours, the resulting product is separated by aluminum column (eluent is tetrahydrofuran), dialyzed (regenerated cellulose dialysis bag MWCO: 1000D), freeze-dried (lyophilized temperature -60 ℃), obtain atom transfer radical polymerization initiator;

[0059]Step 2: Dissolve 0.3 g of the atom transfer radical polymerization initiator obtained in step 1 in 6 mL of isopropanol / water mixed solvent, put it into a polymerization bottle, and then add 3 g of N-isopropylacrylamide, 0.3 g of tert-butyl methacrylate and 50 mg of cuprous chloride were fully dissolved, and protected by argon. After ...

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Abstract

The invention discloses a preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions. After the gel is dissolved in a silver-loaded graphene solution, it is sprayed on the wound surface and stimulated by the temperature of the wound surface. An irreversible hydrogel is formed in response. The temperature-sensitive hydrogel provided by the present invention has a simple preparation method, and has the functions of antibacterial and wound healing at the same time. It is used as a wound dressing, has obvious effects, and has great potential for clinical application.

Description

technical field [0001] The invention relates to a preparation method and application of a heat-induced irreversible composite hydrogel with antibacterial and wound healing functions. Background technique [0002] Hydrogel is a new type of wound dressing material, which is a three-dimensional cross-linked porous material made of good biocompatibility and biodegradability polymers. The hydrogel contains a large amount of water, has adjustable mechanical properties, and can be easily injected or sprayed on the wound surface. Compared with conventional wound treatment methods such as wound sutures and tapes, the hydrogel can adhere to the wound surface quickly. , Reduce bleeding in the suture area, prevent postoperative complications, and promote wound healing. Based on this, the application of hydrogel materials in antibacterial and trauma wound dressings has attracted the attention of researchers, and some hydrogel wound dressings have been commercialized, such as BioGlue (me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08F220/54C08F220/18C08F220/20
CPCA61L26/0066A61L26/008A61L26/0095A61L2300/104A61L2300/404A61L2300/412C08F220/54C08F2438/01C08L71/02C08L25/06C08F220/1804
Inventor 何涛孙天赐闫旭方蔚伟陆杨徐晓莉
Owner HEFEI UNIV OF TECH
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