Antimicrobial super-smooth material for medical indwelling catheter

A catheter and polyetheramine thiazolidine technology, which is applied in the field of antibacterial and ultra-smooth medical indwelling catheter materials, can solve the problems of inability to guarantee the antibacterial properties of the catheter, poor chemical stability, poor adhesion, etc., and achieves no equipment dependence. High, the preparation method is easy to operate, and the antibacterial properties are evenly distributed.

Inactive Publication Date: 2019-04-05
张 桂玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of material can enhance the antibacterial and super-slip properties of the material to a certain extent, but this kind of medical indwelling catheter is multi-layer composite, the bonding between the layers is not good, and it is easy to delaminate during use, especially in the body fluid environment However, the chemical stability is not good, and the antibacterial medium layer is located between the tube wall and the super-slip medium layer, which cannot guarantee the antibacterial properties of the entire catheter

Method used

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  • Antimicrobial super-smooth material for medical indwelling catheter

Examples

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Effect test

Embodiment 1

[0029] An antibacterial super-slippery medical indwelling catheter material is made by the following preparation method:

[0030] Ⅰ Preparation of polyetheramine thiazolidine-2,4-dicarboxylic acid amide: 1 kg of thiazolidine-2,4-dicarboxylic acid and polyetheramine in the amount of thiazolidine-2,4-dicarboxylic acid D-2000 was dissolved in 10kg of deionized water and placed in an autoclave. After nitrogen purging, the temperature in the autoclave was kept at 270°C and the pressure at 3.0MPa, and the reaction was stirred for 6 hours, and then within 2 hours Slowly exhaust and reduce the pressure to 1.0MPa, and at the same time raise the temperature in the autoclave to 305°C, then control the temperature between 230°C and stir for 12 hours under nitrogen atmosphere to obtain polyetheraminethiazolidine-2,4- Dicarboxylic acid amides;

[0031] Preparation of polycondensate II: Add 1kg of N,N-propargylaniline and 2,6-bis(4-azidobenzylidene)-4methylcyclohexanone 2.19kg to 10kg of di...

Embodiment 2

[0036] An antibacterial super-slippery medical indwelling catheter material is made by the following preparation method:

[0037] Ⅰ Preparation of polyetheramine thiazolidine-2,4-dicarboxylic acid amide: 1 kg of thiazolidine-2,4-dicarboxylic acid and polyetheramine in the amount of thiazolidine-2,4-dicarboxylic acid D-2000 was dissolved in 11kg of deionized water and placed in a high-pressure reactor. After purging with helium, the temperature in the high-pressure reactor was kept at 280°C and the pressure was kept at 3.5MPa. Slowly exhaust and reduce the pressure to 1.0MPa within hours, and at the same time raise the temperature in the autoclave to 308°C, then under vacuum conditions, control the temperature between 235°C, stir and react for 12.5h to obtain polyetheraminethiazolidine-2 ,4-dicarboxylic acid amide;

[0038] Preparation of polycondensate II: Add 1kg of N,N-propargyl aniline and 2.19kg of 2,6-bis(4-azidobenzylidene)-4 methylcyclohexanone to N,N-dimethyl In 11.5...

Embodiment 3

[0043] An antibacterial super-slippery medical indwelling catheter material is made by the following preparation method:

[0044] Ⅰ Preparation of polyetheramine thiazolidine-2,4-dicarboxylic acid amide: 1 kg of thiazolidine-2,4-dicarboxylic acid and polyetheramine in the amount of thiazolidine-2,4-dicarboxylic acid D-2000 was dissolved in 15kg of deionized water and placed in a high-pressure reactor. After purging with neon gas, the temperature in the high-pressure reactor was kept at 285°C and the pressure was kept at 4.0MPa, and the reaction was stirred for 7 hours, and then 2 hours Slowly exhaust the inside and reduce the pressure to 1.0MPa, and at the same time, raise the temperature in the high-pressure reactor to 310°C, and then control the temperature between 245°C and stir for 13.5 hours under a nitrogen environment to obtain polyetheramine thiazolidine-2, 4-Dicarboxylic acid amide;

[0045] Preparation of polycondensate II: Add 1kg of N,N-propargyl aniline and 2,6-b...

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Abstract

The invention discloses an antimicrobial super-smooth material for a medical indwelling catheter. The material is prepared through the following preparation method of (1) polyether amine thiazolidine-2,4-dicarboxylic acylamide preparation; (2) condensation polymer preparation; (3) condensation polymer ionization; (4) catheter material formation. The invention also discloses the medical indwellingcatheter prepared from the antimicrobial super-smooth material for the medical indwelling catheter. The antimicrobial super-smooth material for the medical indwelling catheter disclosed by the invention has the advantages of continuous bacteria resistance and bacteriostasis effects, surface hydrophilic lubrication performance, flexibility, biocompatibility and excellent comfort; the intubatton ofthe medical indwelling catheter prepared from the material is easy; the treatment effect is effectively improved; the pain of patients is reduced.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an antibacterial super-slippery medical indwelling catheter material. Background technique [0002] With the development of medical technology, medical indwelling catheters are not only used for the rescue and treatment of critically ill patients, but also widely used in medical practice, such as intravenous infusion, drug therapy, total intravenous nutrition, hemodynamic testing, etc., especially It is the preferred vascular route for patients with uremia for initial hemodialysis, rescue of poisoning, acute renal failure and immature arteriovenous fistula. As a safe and effective tool for diagnosis and treatment, indwelling catheters can be placed in blood vessels, thereby reducing the number of punctures, reducing the pain of patients, and reducing the workload of nurses. It is widely used. [0003] According to the needs of surgery or nursing, it is often necessary to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/04A61L29/06A61L29/14
CPCA61L29/043A61L29/06A61L29/14C08L79/06C08L63/00C08L5/04
Inventor 张桂玲李华
Owner 张 桂玲
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