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Surface rubidium-doped titanium material as well as preparation method and application thereof

A rubidium salt and reaction technology, which is applied in the surface rubidium-doped titanium material and its preparation field, can solve the problems of high postoperative infection rate, lack of local bone tissue integration, insufficient antibacterial performance of titanium surface, etc., and achieve wide application prospects and good Anti-Staphylococcus aureus, the effect of solving wound infection

Active Publication Date: 2019-04-09
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, joint replacement and spinal internal fixation methods are invasive operations. Even after alkali heat treatment, the surface of titanium materials still has insufficient antibacterial performance and lack of local bone tissue integration, which makes postoperative complications caused by related bacteria (such as Staphylococcus aureus) infection high infection rate

Method used

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  • Surface rubidium-doped titanium material as well as preparation method and application thereof
  • Surface rubidium-doped titanium material as well as preparation method and application thereof
  • Surface rubidium-doped titanium material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Use 400-mesh, 600-mesh, 800-mesh, 1200-mesh sandpaper to polish the pure titanium material until the surface is smooth without scratches, then use ethanol, acetone, and deionized water to perform ultrasonic cleaning, dry and blow dry; the diameter of the pure titanium material is 14.5mm round titanium material with a thickness of 1mm is soaked in 5ml 5M sodium hydroxide solution for alkali heat treatment, the treatment temperature is 55°C, and the time is 24h; use deionized water to ultrasonically clean the titanium material after alkali heat treatment to neutral , dry and blow dry; soak the surface-dried and alkali heat-treated titanium material in 1M rubidium chloride solution for rubidium alkali heat treatment, the treatment temperature is 55°C, and the time is 12h; finally, the above-mentioned alkali heat treated and rubidium alkali heat treated The titanium material is calcined at high temperature at a temperature of 550°C, the heating rate is 5°C / min, and the time ...

Embodiment 2

[0064] Polish the Ti-6Al-4V titanium material with 400 mesh, 600 mesh, 800 mesh, and 1200 mesh sandpaper until the surface is smooth without scratches, and then use ethanol, acetone, and deionized water to perform ultrasonic cleaning and dry it; Soak a titanium alloy sheet with a thickness of 1 mm in 5ml of 5M potassium hydroxide solution for alkali heat treatment at a temperature of 65°C for 18 hours; use deionized water to ultrasonically clean the titanium material after alkali heat treatment, and dry it; The dried and alkali-heat treated titanium material is soaked in 2.5M rubidium nitrate solution for rubidium alkali heat treatment, the treatment temperature is 65°C, and the time is 18h; finally, the above-mentioned titanium material that has been subjected to alkali heat treatment and rubidium alkali heat treatment is calcined at high temperature, calcined The temperature is 650°C, the heating rate is 5°C / min, and the time is 18h, and the furnace is air-cooled to obtain th...

Embodiment 3

[0089] Polish the Ti-6Al-4V titanium material with 400 mesh, 600 mesh, 800 mesh, and 1200 mesh sandpaper until the surface is smooth without scratches, and then use ethanol, acetone, and deionized water to perform ultrasonic cleaning and dry it; The titanium alloy sheet with a thickness of 1 mm is soaked in 5ml of 5M strontium hydroxide solution for alkali heat treatment, the treatment temperature is 75 ° C, and the time is 24 hours; use deionized water to ultrasonically clean the titanium material after alkali heat treatment, and dry it; The dried and alkali-heat treated titanium material is soaked in 5M rubidium sulfate solution for rubidium alkali heat treatment. The treatment temperature is 75°C for 24 hours. The temperature is 700°C, the heating rate is 5°C / min, and the duration is 24h. Air-cooled with the furnace, and the surface rubidium-doped titanium material is obtained.

[0090] Figure 4 (a) is the XPS diagram of the surface-doped rubidium-titanium material obtain...

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Abstract

The invention relates to a surface rubidium-doped titanium material as well as a preparation method and application thereof. The preparation method comprises the following steps: cleaning a titanium material after alkali hot treatment to be neutral, drying, then soaking in a rubidium salt solution for reaction and obtaining a titanium material after rubidium salt treatment; calcining the titaniummaterial after rubidium salt treatment at a temperature of 500-750 DEG C to obtain the surface rubidium-doped titanium material; in the rubidium salt solution, the concentration of rubidium ions is 1-10 mol / L. The surface rubidium-doped titanium material provided by the invention has a staphylococcus aureus growth resistance function, is good in biocompatibility and free from cytotoxicity, does not affect the cell proliferation and has a good effect on inducing osteoblastic differentiation of preosteoblasts. The material has antibacterial property and biocompatibility and can effectively solvewound infection and other problems when the titanium material is clinically applied, thereby having a wide application prospect in clinical bone repair.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a surface-doped rubidium-titanium material and its preparation method and application Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium and its alloys are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium as Bone replacement material. [0003] However, titanium and its alloys still have problems such as low bonding strength and mismatching mechanical properties when used as direct implants. Since the titanium dioxide passivation layer on the titanium surfa...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30A61L27/54
CPCA61L27/06A61L27/306A61L27/54A61L2300/102A61L2300/404A61L2300/606A61L2420/02A61L2430/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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