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A kind of separation method of active ingredient of Oryx sativa

A technology of active ingredients and separation methods, which is applied in the field of efficient separation of active ingredients of Rubescens japonicus, can solve the problems of difficult regeneration of activated carbon, poor decolorization effect, unsatisfactory effects, etc., to reduce the discharge of "three wastes" and reduce the content of impurities , The effect of simplifying the process

Active Publication Date: 2021-08-06
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If it takes a long time to soak and decolorize at room temperature, and the decolorization effect is not good, the activated carbon is not easy to regenerate, causing waste and environmental pollution.
[0008] In summary, it can be seen that the current methods of pretreatment, decolorization and impurity removal of Oryx chinensis extract are not satisfactory.

Method used

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  • A kind of separation method of active ingredient of Oryx sativa
  • A kind of separation method of active ingredient of Oryx sativa

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Get 1 kilogram of Rubescensia dry leaves and extract and concentrate with 95% ethanol to obtain 100 grams of Rubescens oriolis extract, wherein the content of Rubescensin A is 3.24%. The liquid chromatogram of the extract is shown in figure 1 .

[0028] Weigh 50 g of the concentrated Oryx sativa extract and put it into a supercritical extraction kettle, fix the MILLPORE Ultracel3KDa ultrafiltration membrane on the lower part of the barrel, put it into the separation kettle Ⅰ, and then flush it into the supercritical CO 2 The fluid is pressurized and circulated, the extraction pressure is 10MPa, the temperature is 40°C, the pressure of the separation tank I is 9 MPa, the temperature is 35°C, the pressure of the separation tank II is 3MPa, the temperature is 40°C, and the fluid flow rate is 5L h -1 , the extraction time was 0.5 hours. After treatment, the color of Rubescensia extract changed from dark brown-green to orange-red, the content of impurities such as pigments ...

Embodiment 2

[0030] Take 1 kg of dried leaves of Rubescens oriolis and extract and concentrate with 95% ethanol to obtain 100 grams of Rubescens oriolis extract, in which the content of Rubescensin A is 3.24%.

[0031] Weigh 50 g of the concentrated Oryx sativa extract and put it into a supercritical extraction kettle, fix the Miilipore 3KD ultrafiltration membrane on the lower part of the barrel, put it into the separation kettle I, and then flush it into the supercritical CO 2 The fluid is pressurized and circulated, the extraction pressure is 20MPa, the temperature is 50°C, the pressure of the separation tank I is 19MPa, the temperature is 45°C, the pressure of the separation tank II is 4MPa, the temperature is 35°C, and the fluid flow rate is 10L h -1 , and the extraction time was 1 hour. After treatment, the color of Rubescensia extract changed from dark brown-green to orange-red, the content of impurities such as pigments in Rubescens oriolis extract decreased, and the content of Rub...

Embodiment 3

[0033] Take 1 kg of dried leaves of Rubescens oriolis and extract and concentrate with 95% ethanol to obtain 100 grams of Rubescens oriolis extract, in which the content of Rubescensin A is 3.24%.

[0034] Weigh 50 g of the concentrated Oryx sativa extract and put it into a supercritical extraction kettle, fix the MILLPORE Ultracel3KDa ultrafiltration membrane on the lower part of the barrel, put it into the separation kettle Ⅰ, and then flush it into the supercritical CO 2 The fluid is pressurized and circulated, the extraction pressure is 15MPa, the temperature is 55°C, the pressure of the separation tank I is 14 MPa, the temperature is 40°C, the pressure of the separation tank II is 3MPa, the temperature is 35°C, and the fluid flow rate is 7L·h -1 , and the extraction time was 2 hours. After treatment, the color of Rubescensia extract changed from dark brown-green to orange-red, the content of impurities such as pigments in the extract of Rubescens oriolis decreased, and th...

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Abstract

The invention relates to the field of supercritical extraction, in particular to a high-efficiency separation method for the effective components of Rubescens japonicus. Weigh the concentrated ethanol extract of Rubescens japonicus and place it in a supercritical extraction kettle, and fill it with supercritical CO 2 The fluid starts the extraction cycle, and the extract passes through the ultrafiltration membrane and then precipitates in the separation tank. The fluid flow rate is 5-20L / h, and the extraction time is 0.5-3 hours. The present invention is completed once in a supercritical system without the need for other equipment and devices. The color of the treated Oridonium extract changes from dark brown-green to orange, and the content of Oridonin increases from 3.24% to 4.17%. , the effect of decolorization and impurity removal is obvious, and the content of active ingredients is increased.

Description

technical field [0001] The invention relates to the field of supercritical extraction, in particular to a high-efficiency separation method for the effective components of Rubescens japonicus. Background technique [0002] Rabdosia rebescens ( Hemsl ) Hara is the dry aboveground part of the perennial herbaceous plant of the family Lamiaceae. It is mainly produced in Jiangxi, Jiangsu, Anhui, Jiyuan, Jiaozuo, Hebi and other places at the southern foot of Taihang Mountain in Henan. According to medical records: Donglingcao tastes sweet and bitter, slightly cold in nature, and has the effects of clearing away heat and detoxification, reducing inflammation and relieving pain, invigorating the stomach and anti-tumor. Clinical experiments have proved that Rubescens japonicus has a certain effect on esophageal cancer, cardia cancer, liver cancer, prostate cancer, bladder cancer, etc., and has a significant effect on esophageal epithelial hyperplasia. Experts in the pharmaceutical i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D11/02A61K36/53
CPCA61K36/53A61K2236/37B01D11/0203
Inventor 杨靖刘春奎杨鹏飞白冰张改红毛多斌侯佩时国庆
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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