a phenolic compound

A technology of phenolic compounds and compounds, applied in organic chemistry, drug combination, non-central analgesics, etc., can solve problems such as no anti-inflammatory effect of COX-2
CN109627229BActive Publication Date: 2021-01-19SHENZHEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN UNIV
Publication Date
2021-01-19

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Abstract

The invention provides a phenolic compound and relates to the field of chemicals. The chemical structure of the phenolic compound is shown in the formula I, and the formula I is shown in the description. The phenolic compound can be used as an inhibitor of epoxidase 2 and used for inhibiting the inflammation. The invention further provides a method for preparing the phenolic compound.
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Description

technical field

[0001] The invention belongs to the field of chemical medicine and relates to a phenolic compound. Background technique

[0002] Inflammation is a common pathological phenomenon accompanying many disease states, and its essence is a defense response of the body to various damaging stimuli. Small molecule inflammatory mediators that mediate inflammatory responses include histamine, arachidonic acid, prostaglandins (PG) and leukotrienes. Among them, arachidonic acid can be catalyzed by cyclooxygenase (COX) to generate PG, leading to vasodilation, contraction of bronchi, gastrointestinal and uterine smooth muscles, promoting the exudation of inflammatory mediators, and generating heat to produce inflammatory reactions. Commonly used anti-inflammatory drugs are steroidal anti-inflammatory drugs (SAIDs) except glucocorticoid inhibitors used for critical diseases, aspirin, ibuprofen, indomethacin, etc. are non-steroidal anti-inflammatory drugs (NSAIDs). ), the cy...

Claims

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