Filter membrane for removing low density lipoproteins, and preparation method thereof

Abstract

The invention discloses a filter membrane for removing low density lipoproteins, and a preparation method thereof. The filter membrane comprises, by weight, 10-25 parts of amphiphilic chitosan, 20-35parts of sulfonic group-modified cellulose acetate, 2-6 parts of poly(2-methacryloyloxyethyl phosphorylcholine) and 1-4 parts of sodium oleate. The filter membrane can effectively reduce the LDL level in the blood, has a good filtering effect on VLDL, TC and TG, has few influences on the level of beneficial proteins in the blood, such as high density lipoproteins, albumins and immunoglobulin IgG,is suitable for purifying the blood of clinical hyperlipidemia patients, can also be applied to the finishing industry of blood products, and can be combined with relevant separation auxiliary devices to recover useful plasma from the waste human plasma that does not meet the blood transfusion standards and produce blood products with high added values.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and medical device materials, and relates to a medical filter material for blood perfusion, in particular to a filter membrane for removing low-density lipoprotein and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the three major diseases that threaten human health, and has rapidly developed into a disease with the highest morbidity and mortality in some countries and regions, mainly including hyperlipidemia, atherosclerosis, coronary heart disease, cerebral embolism and myocardial infarction. Studies have shown that the increase of low density lipoprotein (low density lipoprotein, LDL) in human blood and the resulting oxidized low density lipoprotein is the key factor in inducing such diseases. Therefore, trying to reduce the level of LDL in the blood can effectively alleviate and cure the above-mentioned diseases. [0003] However, fo...

AI Technical Summary

Problems solved by technology

But these commercial affinity adsorbents still have many problems to be improved

For example, cellulose-immobilized dextran sulfate uses the combination of the negative charge of the adsorbent and the positive charge of LDL to achieve the purpose of adsorption and removal of LDL. However, dextran sulfate can activate the XII blood coagulation factor, and the treatment process needs to be cautious; Another example is that the anionic adsorbent formed by immobilizing polyacrylate on the porous polyacrylamide carrier can only be used once and cannot be regenerated; the affinity adsorbent containing heparin ligand has the risk of heparin falling off and entering the human body with the blood, which may Can cause bleeding, non-clotting side effects

[0004] As an important carrier material for blood purification, there are few technical reports on adsorption and separation using porous membranes

In particular, domestic scholars' research on LDL removal materials mainly focuses on the improvement of LDL adsorbents. There are relatively few studies on LDL filter membrane materials, and their research and development ideas are similar to those of LDL adsorbents. The coupling method is grafted to conventional dialysis membrane materials, such as non-woven fabrics, polyvinylidene fluoride surface membranes, polysulfone fiber membranes, and polyacrylonitrile fiber membranes. The surface graft copolymerization efficiency is not high, The coupling process between specific small molecule ligands and the surface of the substrate is complicated, and there are risks such as ligand detachment

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