Preparation method and use method of hydrogel local anesthesia patch

A hydrogel topical and anesthesia patch technology, applied in the field of anesthesia, can solve the problems of pain in the injection area, excessive reaction, infection of the injection needle, etc., and achieve the effect of avoiding inaccurate anesthesia area, low equipment requirements, and simple operation method.

Inactive Publication Date: 2019-04-26
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the use of traditional syringes for local anesthesia can also bring some additional problems, such as possible fainting due to the

Method used

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Experimental program
Comparison scheme
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Embodiment Construction

[0019] The present invention is further described below in conjunction with specific embodiment:

[0020] A preparation method of a hydrogel local anesthesia patch, comprising the following steps:

[0021] Step 1, the preparation of nano-gold dispersion: the chloroauric acid solution is heated to boiling, trisodium citrate is added thereto, after stirring and mixing, centrifuge at 11000 rpm for 30-60 minutes, remove the supernatant Obtain nano gold dispersion;

[0022] Step 2. Preparation of PDA-PAM hydrogel: configure sodium hydroxide solution with a pH value of 11, add dopamine hydrochloride to the sodium hydroxide solution, stir for 12 hours until the solution turns black completely, then add acrylamide and continue stirring for 2 hours , then add ammonium persulfate and stir for 1 hour, continue to add N,N-methylenebisacrylamide and stir for 30 minutes, and finally add 10 μL of tetramethylethylenediamine to react for 10 seconds to obtain PDA-PAM hydrogel;

[0023] Step 3...

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Abstract

The invention discloses a preparation method of a hydrogel local anesthesia patch. The preparation method comprises the following steps of 1, nanogold dispersion liquid preparation; 2, PDA-PAM hydrogel preparation; 3, PDA-PAM-AuNps hydrogel preparation; 4, hydrogel local anesthesia patch finished product preparation. The hydrogel local anesthesia patch can generate heat under the excitation of near infrared light, and the penetration of local anesthesia medicine in the patch in tissues is promoted; meanwhile, the hydrogel local anesthesia patch also has the following technical advantages that1, a microneedle is used for puncturing the surface of a mucosa or the skin; the aching feeling is weak; 2, some problems and defects such as unprecise anesthesia region, swelling after injection andslow recovery caused by injection anesthesia can be avoided; 3, the process is simple and safe; the operation method is simple; the equipment requirements are low; the hydrogel local anesthesia patchis suitable for large-scale production and industrialization.

Description

technical field [0001] The invention relates to the field of anesthesia, in particular to a method for preparing a hydrogel local anesthesia patch and a method for using it. Background technique [0002] Local anesthesia is widely used in modern medicine. It refers to the use of local anesthetics to temporarily block the sensory conduction of nerve endings and fibers in a certain area of ​​the body, so that the pain in this area disappears. Taking oral treatment as an example, local anesthesia is commonly used in the treatment of endodontics, tooth extraction, minor maxillofacial surgery and pain treatment, and dental implants. [0003] Different local anesthesia methods are used clinically, such as topical anesthesia. The local anesthetic drug is made into a gel state and applied to the area that needs anesthesia. discomfort. There are also studies reporting a new method of injecting medicine without a needle, using a high-speed high-pressure injector to inject anesthetic...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K47/02A61K47/34A61K9/00A61K31/167A61K31/4458A61P23/02
CPCA61K9/0021A61K9/06A61K9/7023A61K31/167A61K31/4458A61K47/02A61K47/34A61P23/02
Inventor 王小磊张凤丁星伟廖岚
Owner NANCHANG UNIV
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