Heparin sodium modified metal organic framework thin film and its preparation method and application
A metal-organic framework and heparin sodium technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., to achieve the effect of selective cation transport, avoid complex organic synthesis steps, and simple operation
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[0040] The preparation method of zinc hydroxide nanowire solution among the present invention is:
[0041] Add ethanolamine to the mixture of ethanol and water to obtain ethanolamine solution; add zinc nitrate to the mixture of ethanol and water to obtain zinc nitrate solution; then mix equal volumes of ethanolamine solution and zinc nitrate solution, stir, and react The container is sealed, and after 0.5-1.5 hours, a zinc hydroxide nanowire solution is obtained.
[0042] The concentration of ethanolamine solution is 1.6mM (mmol / L); the concentration of zinc nitrate solution is 4mM (mmol / L); the volume ratio of ethanol and water used to dissolve ethanolamine or zinc nitrate is 1:1.5.
[0043] The zinc hydroxide nanowire solutions used in the following examples are all prepared by the above method, but it should be pointed out that this is only the preferred mode of the present invention, and each parameter can be adjusted according to actual needs, or the existing technology c...
Embodiment 1
[0045]1) Mix 5ml of zinc hydroxide nanowire solution with 0.2ml of heparin sodium solution with a mass fraction of 0.01%, magnetically stir for 5 minutes, and vacuum filter directly on the anodized aluminum porous membrane to form a composite layer of nanowire and heparin sodium membrane. The diameter of the anodized aluminum porous membrane is 2.5cm, the pore diameter is 200nm, and the porosity is 50%;
[0046] 2) Suspend the composite film of nanowires and sodium heparin in an airtight container filled with 0.5 g of 2-methylimidazole, and react at 120° C. for 24 hours.
[0047] figure 1 It is a schematic diagram of the preparation process of the metal-organic framework film modified by the above-mentioned sodium heparin; figure 2 The SEM image of the heparin sodium-modified metal-organic framework film prepared for this example shows that the film is a polycrystalline film with good grain intergrowth and continuous film without cracks.
Embodiment 2
[0049] 1) Mix 5ml of zinc hydroxide nanowire solution with 0.4ml of heparin sodium solution with a mass fraction of 0.01%, magnetically stir for 5min, and vacuum filter directly on the anodized aluminum porous membrane to form a composite layer of nanowire and heparin sodium Membrane, the diameter of the anodized aluminum porous membrane is 2.5cm, the pore diameter is 200nm, and the porosity is 50%;
[0050] 2) Suspend the composite film of nanowires and sodium heparin in an airtight container filled with 0.5 g of 2-methylimidazole, and react at 120° C. for 24 hours.
[0051] image 3 The SEM image of the heparin sodium-modified metal-organic framework film prepared for this example shows that the film is a polycrystalline film with good grain intergrowth and continuous film without cracks.
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