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β-cd@cds nanorods applied to photoelectric biosensing and preparation method thereof

A biosensor and nanorod technology, applied in nanotechnology for sensing, nanotechnology for materials and surface science, nanotechnology, etc., can solve problems such as difficult to modify biomolecules

Active Publication Date: 2021-04-16
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to use it as a signal label in the construction of biosensors, the difficulty of modifying biomolecules has become a major bottleneck in its entry into the field of life analysis, and it is urgent for relevant researchers to solve the problem.

Method used

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  • β-cd@cds nanorods applied to photoelectric biosensing and preparation method thereof
  • β-cd@cds nanorods applied to photoelectric biosensing and preparation method thereof
  • β-cd@cds nanorods applied to photoelectric biosensing and preparation method thereof

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Embodiment

[0022] The synthetic route of β-CD@CdS nanorod described in the present invention is as follows figure 1 .

[0023] (1) First, aminated CdS nanorods were synthesized by solvothermal reaction, and then 0.04 g of CdS nanorods and 0.1 g of carboxymethyl-β-cyclodextrin (CM-β-CD) were sequentially added to 5 mL containing 20 mM N-hydroxy Succinimide (NHS) and 10 mM 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) in PBS solution (pH 5.3), stirred at room temperature for 12 h .

[0024] (2) The obtained product was washed and centrifuged twice with deionized water and once with absolute ethanol, and dried in a vacuum oven at 60 °C for 12 h to obtain β-CD@CdS nanorods. Through related material characterization, we found that compared with CdS nanorods, the microscopic morphology of β-CD@CdS nanorods did not change significantly, but its dispersion ( figure 2 ) and greatly improved water solubility (eg image 3 and Figure 4 ).

[0025] (3) In addition, using β...

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Abstract

The invention discloses a β‑CD@CdS nanorod applied to photoelectric biosensing and a preparation method thereof, the steps of which are: dissolving aminated CdS nanorods and carboxymethyl‑β‑cyclodextrin In the PBS buffer solution of hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, after stirring at room temperature for a certain period of time, the resulting product was washed and dried, namely β‑CD@CdS nanorods can be obtained. The β‑CD@CdS nanorods prepared by the present invention have excellent photoelectric conversion efficiency, good biocompatibility and stability, and have been applied to the construction of photoelectric DNA biosensors, and can be extended to electrochemiluminescence, fluorescence and visualization It has broad market application prospects in genetic testing, food safety, clinical diagnosis, and environmental testing.

Description

technical field [0001] The invention relates to the preparation of a β-CD@CdS nanorod applied to photoelectric biosensing technology, and belongs to the field of semiconductor nanomaterials and life analysis. Background technique [0002] In recent years, high-risk diseases have plagued many countries and regions, posing a serious threat to people's health and even life. Therefore, rapid and sensitive detection of disease biomarkers, viruses, bacteria, heavy metal ions and other targets is particularly important. Compared with traditional optical and electrochemical methods, photoelectric biosensing has the characteristics of low background signal, high sensitivity, simple instrument and easy miniaturization. In photoelectric analysis, photoactive materials have a crucial impact on the performance of sensors. Among them, CdS, as a narrow bandgap semiconductor material, has the characteristics of visible light excitation, and is widely used in photoelectric sensing, photocat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26B82Y15/00B82Y30/00B82Y40/00
CPCB82Y15/00B82Y30/00B82Y40/00G01N27/26
Inventor 臧杨樊静江婧婧薛怀国
Owner YANGZHOU UNIV