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Traditional Chinese medicine prescription capable of treating herpes simplex keratitis and reducing recurrence of herpes simplex keratitis

A technology for viral keratitis and herpes simplex, applied in antiviral agents, drug combinations, pharmaceutical formulas, etc., can solve the problems of immune disorders that cannot be improved, viruses cannot be completely eliminated, and HSV virus is easy to mutate, etc., to achieve good anti-virus And anti-relapse, reduce blinding rate, inhibit virus replication effect

Inactive Publication Date: 2019-05-03
EYE HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although exogenous interferon combined with ACV therapy has achieved good curative effect on some refractory HSK patients, the immune disorder state of the body still cannot be improved, and potential recurrence is inevitable; vaccine is an ideal means to control viral diseases. In terms of HSK and its recurrence, various vaccine research has made some progress, but the HSV virus is very easy to mutate, and it will take some time before clinical application due to reasons such as the HSV virus is very easy to mutate, and it will quickly develop drug resistance to the vaccine.
[0005] Clinical and experimental studies over the years have shown that the low immune function of the body is an important reason for virus invasion, inducing virus activation, and causing disease or recurrence. Simple treatment with antiviral drugs can inhibit virus replication and control the current outbreak. , but because the virus remaining in the eyes or latent in the trigeminal ganglion cannot be completely eliminated, when the body's immune function is low, such as overwork, cold or application of corticosteroids, it may still recur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Example 1. Herpes simplex virus keratitis (dendritic):

[0020] Patient Liu, female, 40 years old.

[0021] First visit: January 18, 2017.

[0022] Chief complaint: repeated left eye redness, tearing and blurred vision for 2 years.

[0023] Medical history: It was diagnosed as "viral keratitis of the left eye" in another hospital, and it recurred 5 times. It was relieved after using acyclovir eye drops, pranoprofen eye drops, and tobramycin dexamethasone eye drops, and the drug was stopped After relapse.

[0024] Specialist examination: visual acuity: Vod: 1.0, Vos: 0.1 (correction does not improve), bulbar conjunctival hyperemia +, corneal epithelium infiltrates in dendrites, fluorescein staining (++). Intraocular pressure: 15mmHg.

[0025] Diagnosis: Herpes simplex virus keratitis (dendritic) of the left eye

[0026] treat:

[0027] 1.0.2% fluorometholone eye drops Tid, ganciclovir ophthalmic gel Tid

[0028] 2. Chinese medicine treatment:

[0029] 15 grams of...

example 2

[0039] Example 2. Herpes simplex virus keratitis (discoid stromal type):

[0040] Patient Jiang, female, 36 years old.

[0041] First visit: January 16, 2018.

[0042] Chief complaint: repeated left eye redness, tearing and loss of vision for 1 year.

[0043] Medical history: It was diagnosed as "viral keratitis of the left eye" in another hospital. It had recurred 8 times and was relieved after using acyclovir eye drops, tobramycin eye drops, and subconjunctival injection of triamcinolone acetonide injection.

[0044] Specialist examination: visual acuity: Vos: 0.2, mixed hyperemia of bulbar conjunctiva +++, edema of corneal epithelial matrix (+++). Intraocular pressure: 8.6mmHg.

[0045] Diagnosis: left eye viral keratitis (discoid stromal type).

[0046] treat:

[0047] 1. Beifushu eye drops Tid ganciclovir ophthalmic gel Tid, subconjunctival injection of dexamethasone 0.6ml;

[0048] 2. Chinese medicine treatment

[0049] 15 grams of raw Astragalus, 6 grams of fried...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine prescription capable of treating herpes simplex keratitis and reducing recurrence of the herpes simplex keratitis. The traditional Chinese medicine prescription consists of the following components in gram by mass of 9-24g of raw radix astragali, 6-12g of parched bighead atractylodes rhizomes, 9-12g of divaricate saposhnikovia roots, 12-18g of honeysuckle flowers, 9-18g of common bletilla tubers, 3-9g of herba epimedii, 12-24g of dandelions, 9-15g of puncturevine caltrop fruits, 9-18g of radix lithospermi and 6-10g of cicada slough; for people suffering from keratohelcosis, 6-10g of radix stephaniae tetrandrae and 10-15g of radix sophorae flavescentis are additionally added; and treatment is performed based on syndrome differentiation, the components are added or reduced according to the syndromes, the components are decocted, and the traditional Chinese medicine prescription is orally taken. The traditional Chinese medicine prescription is scientific and reasonable, conforms to syndrome differentiation of the traditional Chinese medicine theory, can treat both symptoms and root causes at the same time, can effectively treat the herpes simplex keratitis, can alleviate cornea lesion damage degree, can shorten disease course, can improve sight, can reduce the recurrence rate, can effectively reduce blinding rate and is freefrom toxic and side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription for treating herpes simplex virus keratitis and reducing its recurrence, and belongs to the technical field of traditional Chinese medicine formulas. Background technique [0002] Herpes simplekeratitis (HSK) is a non-suppurative immunopathological eye disease caused by herpes simplex virus (HSV) infection, with rapid onset, easy recurrence and blindness rate advanced features. In the survey of blind patients in cities in my country, corneal blindness takes the second place, while HSK takes the first place, accounting for 42.85%. About 400,000 people in the United States suffer from HSK every year, and 25%-35% of them relapse within 1-2 years after the initial infection; domestic research on the recurrence of 180 eyes within 1-3 shows that the recurrence rates are 20.0 %, 31.5%, 33.5%. In recent years, due to the unreasonable application of antibiotics and hormones, the continuous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P27/02A61P31/22A61K35/64
Inventor 亢泽峰
Owner EYE HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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