Preparation method of s-isomer indoxacarb

Abstract

The invention relates to the field of chemical synthesis, and particularly discloses a brand-new catalyst and a preparation method of s-isomer indoxacarb by using the catalyst, the catalyst is prepared from 3-tert-butyl-5-chloromethyl salicylaldehyde and cyclohexanediamine as raw materials, the catalyst is used for replacing original cinchonine and other cinchona alkaloid catalysts, and is appliedto asymmetric synthesis reaction of tert-butyl hydroperoxide and 5-chloro-2-methoxycarbonyl-1-indanone ester, the selectivity of the asymmetric synthesis process is greatly improved, and the contentof the s-isomer indoxacarb is increased from 75% to more than 98%, the recycling of the high-efficiency chiral catalyst is realized, the production cost is greatly reduced, the synthesis process of the catalyst is simple, the industrialization is facilitated, and a good foundation is laid for producing high-quality indoxacarb.

Description

technical field [0001] The invention relates to the field of chemical synthesis, and specifically discloses a preparation method of S-body indoxacarb. Background technique [0002] Indoxacarb is a new type of oxadiazine insecticide with high efficiency and low toxicity developed by DuPont Company of the United States. It has dual effects of contact killing and stomach poisoning, and can effectively solve resistant pests. It has no cross-resistance with other insecticides such as pyrethroids, organophosphorus, and carbamates, and can well solve the problems of rice leaf rollers, rice stem borers and resistant diamondback moths that are difficult to control in the market. In addition, indoxacarb has a very wide insecticidal spectrum, and one drug can prevent multiple diseases. While preventing and controlling noctuid pests, it also has a good inhibitory effect on mirid bugs, so it is a very good comprehensive management tool. , can well solve the current problems of residues ...

AI Technical Summary

Problems solved by technology

[0004] First, cinchona base catalysts such as cinchonin are used, but the efficiency of this type of catalyst is low, and the S body content of the synthesized indoxacarb original drug is about 70%;

[0005] Second, metal complex catalysts are used. In 2007, DuPont Company of the United States reported a metal zirconium catalyst, but this type of catalyst cannot be recycled, and the production cost is relatively high, and the S body content of the obtained indoxacarb original drug is about 90%;

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