2 results about "Cinchona Alkaloids" patented technology

The invention relates to the technical field of scalp care, and discloses a scalp itching relieving composition and application thereof.The scalp itching relieving composition is mainly composed of forsythin, isatis tinctoria extract, cinchona alkaloid, a pH regulator and a solvent and can be used for shampoo, hair conditioners, scalp essence, scalp spray and hair masks. The fructus forsythiae phenol, the isatis tinctoria extract and the cinchona alkaloid in the scalp itching-relieving composition have a remarkable synergistic effect, and the scalp itching-relieving composition is efficient in itching-relieving effect, long-acting, mild, safe, low in irritation and suitable for various scalp types.

The invention discloses a method for synthesizing a camptothecin chiral precursor with high enantioselectivity, and belongs to the field of organic synthesis. In the invention, the preparation of a chiral precursor amide compound of camptothecin comprises the following steps: synthesizing corresponding aryl (E)-2-ethylbutyl-2-olefine acid ester, mixing the aryl (E)-2-ethylbutyl-2-olefine acid ester with a phase transfer catalyst derived from cinchona alkaloid in an organic solvent, sequentially adding acid, potassium permanganate and a small amount of potassium fluoride solution for reaction, and after the reaction is finished, performing suction filtration to obtain the chiral precursor amide compound of camptothecin. Carrying out amine ester exchange with diethylamine; and evaporating the solvent, and quickly purifying by using a silica gel column to obtain the camptothecin precursor chiral amide compound with high enantioselectivity. The invention aims at providing a new thought and a new method for total synthesis of camptothecin based on a camptothecin chiral precursor reported in literatures, and broadens a synthesis route for synthesizing camptothecin.