Unlock instant, AI-driven research and patent intelligence for your innovation.

Tissue fluid detection device

A detection device and interstitial fluid technology, applied in the direction of catheters, etc., can solve the problems of limited number of patient detections, inability to realize real-time detection of human blood sugar, and only applicable, and achieve significant clinical application value and prospects, realize continuous detection of physiological information, and realize real-time detection. The effect of detection

Inactive Publication Date: 2019-05-10
INST OF FLEXIBLE ELECTRONICS TECH OF THU ZHEJIANG +1
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are mainly two methods of blood glucose detection widely adopted in the world: (1) taking venous blood and then using a biochemical analyzer for centrifugation analysis. This method can obtain the blood glucose content more accurately, but the operation is very complicated and the process is slow. It is suitable for hospital testing; (2) fingertip blood collection, and then use a rapid blood glucose meter to detect blood sugar levels. This method is simple to detect, but due to the cost and acceptance of blood collection frequency, the number of detections per day is limited for general patients
Therefore, neither of these two detection methods can achieve the purpose of real-time detection of human blood sugar, which is not conducive to the precise control of blood sugar concentration through drugs; moreover, these two methods will cause trauma to the human body.
However, due to the complexity of the human body, optical methods, microwave detection methods, impedance methods, and electrochemical methods that are still being developed currently have low signal-to-noise ratios, low sensitivity, and selective Problems such as poor performance and large errors are far away from practical applications

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tissue fluid detection device
  • Tissue fluid detection device
  • Tissue fluid detection device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Such as figure 1 As shown, the interstitial fluid detection device of this embodiment is used to detect physiological information such as human blood sugar concentration, hormone concentration, lactic acid concentration, and drug concentration, so as to monitor the amount of drug used by the human body and the degree of metabolism of the drug, so as to realize the prevention of diseases. Precision therapy.

[0046] The interstitial fluid detection device includes a main body, a microneedle 20, a pressing part 50, and an electrochemical sensor 30. A cavity 100 is formed inside the main body. The microneedle 20 is located on the surface of the main body and has a channel 201 for interstitial fluid to circulate. The hole 201 extends from the tip of the microneedle 20 to the main body and communicates with the cavity 100, the pressing part 50 is connected to the cavity 100 and can press and discharge the air in the cavity 100 to make the cavity 100 A negative pressure envi...

Embodiment 2

[0103] Such as Figure 4 As shown, this embodiment is based on Embodiment 1, the main body further includes at least one first diaphragm check valve 60, and the pressing part 50 is used to control the opening of the first diaphragm check valve 60 or closed, the first diaphragm check valve 60 is used to control the communication or isolation of the cavity 100 with the outside. Therefore, when pressure is applied to the pressing part 50, the first diaphragm check valve 60 opens, and the air in the cavity 100 is discharged from the gap where the first diaphragm check valve 60 opens and the hole 201, so that the cavity 100 is rapidly formed. Negative pressure environment.

[0104] Specifically, the first diaphragm check valve 60 is disposed on the base 10 , one end of the first diaphragm check valve 60 is connected to the base 10 , and the other end is selectively attached to the cover plate 40 . When the pressure is applied to open, the joint of the first diaphragm check valve ...

Embodiment 3

[0120] Such as Figure 7 and Figure 8 As shown, in this embodiment, on the basis of Embodiment 2, the side of the substrate 10 away from the microneedle 20 is provided with a concave micro-channel 101, and at least one end of the micro-channel 101 extends out of the The substrate 10, the first diaphragm check valve 60 is disposed in the micro-channel 101 for controlling the communication or isolation of the micro-channel 101 with the outside.

[0121] Such as Figure 8 As shown, preferably both ends of the micro-channel 101 extend out of the substrate 10, and both ends of the micro-channel 101 are provided with a first membrane check valve 60, so that the micro-channel 101 can pass through the micro-channel 101 faster The air in the cavity 100 is exhausted.

[0122] Specifically, the hole 201 communicates with the micro-channel 101, the interstitial fluid is transported into the micro-channel 101 through the hole 201, and the electrochemical sensor 30 is arranged in the mi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a tissue fluid detection device. The tissue fluid detection device comprises a main body, a microneedle, a compressing portion and an electrochemical sensor, wherein a cavityis formed in the main body, the microneedle is located on the surface of the main body and is provided with a pore passage for a tissue fluid to flow, and the pore passage extends from the tip end ofthe microneedle to the main body and is communicated with the cavity; The compressing portion is connected with the cavity and can compress air discharged out of the cavity to form a negative pressureenvironment in the cavity, and the electrochemical sensor is arranged in the cavity and can be in contact with the tissue fluid flowing through the microneedle so as to detect the glucose concentration of the tissue fluid. The tissue fluid detection device can achieve continuous detection of blood sugar, is high in precision, good in reliability and causes small trauma to a human body, and clinical application can be quickly achieved.

Description

technical field [0001] The invention relates to the technical field of physiological information detection, in particular to an interstitial fluid detection device. Background technique [0002] At present, the collection of the concentration of blood sugar, hormones, lactic acid, etc., or the collection of the concentration of drugs that exist in the human body, such as antibiotics, can play a vital role in the precise treatment of diseases. For example: there is still no medicine and method for completely curing diabetes, so in clinical practice, blood sugar concentration is mainly controlled by injecting insulin or taking hypoglycemic drugs orally. Among them, the dosage of hypoglycemic drugs needs to be adjusted in time according to the blood sugar level of the human body. Therefore, blood sugar detection has become the most important part of diabetes care. [0003] At present, there are mainly two methods of blood glucose detection widely adopted in the world: (1) taki...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1473
Inventor 冯雪杜琦峰陈颖
Owner INST OF FLEXIBLE ELECTRONICS TECH OF THU ZHEJIANG