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Composite film for guiding tissue repair and preparation method and application thereof

A technology to guide tissue and tissue repair, applied in medical science, prosthesis, etc., can solve problems such as difficult regeneration process, slow living process, cell shedding and death, etc., to improve protection effect, accelerate repair, and speed up repair Effect

Active Publication Date: 2019-05-10
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the regenerative composite membrane provided by the invention cannot make the cells adhere well, and the growth of the cells themselves in the three-dimensional environment is called slow, which easily causes the cells to fall off and die.
[0005] Although the existing tissue regeneration membrane can play a role in tissue regeneration, its growth process is slow and cannot well meet the needs of body repair, and since tissue repair is completed by cells, if the cells cannot be well placed on the material Adhesive growth in the medium, the regeneration process of the tissue will be difficult

Method used

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  • Composite film for guiding tissue repair and preparation method and application thereof
  • Composite film for guiding tissue repair and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 A Composite Membrane for Guided Tissue Repair

[0034] A composite membrane that guides tissue repair, comprising a protective barrier layer made of chitosan and polyethylene glycol and a layer made of hyaluronic acid, sodium alginate, arginine-glycine-aspartame A tissue repair layer made of amino acid sequences and nano-microspheres that guides the growth of tissue cells.

[0035] The molecular weight of the polyethylene glycol is 4000Da.

[0036] The preparation method of the composite membrane for guiding tissue repair comprises the following steps:

[0037] S1 10mg chitosan is dissolved in 1% aqueous acetic acid solution by mass percentage to obtain a 1% chitosan solution by mass percentage, and 220 mg polyethylene glycol is dissolved in deionized water to obtain 22% polyethylene glycol by mass percentage. Diol solution, the resulting chitosan solution and polyethylene glycol solution were mixed and stirred for 24 hours to obtain a protective solution, w...

Embodiment 2

[0045] Example 2 A Composite Membrane for Guided Tissue Repair

[0046] A composite membrane that guides tissue repair, comprising a protective barrier layer made of chitosan and polyethylene glycol and a layer made of hyaluronic acid, sodium alginate, arginine-glycine-aspartame A tissue repair layer made of amino acid sequences and nano-microspheres that guides the growth of tissue cells.

[0047] The molecular weight of the polyethylene glycol is 8000Da.

[0048] The preparation method of the composite membrane for guiding tissue repair comprises the following steps:

[0049] S1 is that 30mg chitosan is dissolved in the acetic acid aqueous solution of 3% by mass percentage, is the chitosan solution of 3% by mass percentage, and 320mg polyethylene glycol is dissolved in deionized water, is the polyethylene glycol of 32% by mass percentage. Diol solution, the resulting chitosan solution and polyethylene glycol solution were mixed and stirred for 30 hours to obtain a protecti...

Embodiment 3

[0057] Example 3 A Composite Membrane for Guided Tissue Repair

[0058] A composite membrane that guides tissue repair, comprising a protective barrier layer made of chitosan and polyethylene glycol and a layer made of hyaluronic acid, sodium alginate, arginine-glycine-aspartame A tissue repair layer made of amino acid sequences and nano-microspheres that guides the growth of tissue cells.

[0059] The molecular weight of the polyethylene glycol is 6000Da.

[0060] The preparation method of the composite membrane for guiding tissue repair comprises the following steps:

[0061] S1 20mg chitosan is dissolved in 0.2% aqueous acetic acid solution by mass percentage to obtain a 2% chitosan solution by mass percentage, and 280 mg polyethylene glycol is dissolved in deionized water to obtain 28% polyethylene glycol by mass percentage. Diol solution, the resulting chitosan solution and polyethylene glycol solution were mixed and stirred for 28 hours to obtain a protective solution,...

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Abstract

The invention belongs to the field of biomedical materials, in particular to a composite film for guiding tissue repair and a preparation method and application thereof. The composite film for guidingtissue repair comprises a protection layer prepared from chitosan and polyethylene glycol and a tissue repairing layer prepared from hyaluronic acid, sodium alga acid, an arginine-glycine-aspartic acid sequence and nanoparticles, the protection layer achieves a protection effect, and the tissue repairing layer is used for guiding tissue cell growth. The protection layer degradation time is proper, the tissue repairing layer below can be effectively protected, chitosan and chitosan oligosaccharide ingredients are contained, and external bacterium intrusion can be stopped well. The tissue repairing layer of the composite film can continuously release cell factors, and the cells are guided to grow towards the tissue repairing layer; the arginine-glycine-aspartic acid sequence is contained, adhesion of the cell can be improved, and then repairing of injured tissue is promoted.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite membrane for guiding tissue repair and its preparation method and application. Background technique [0002] The prototype of guided tissue regeneration technology began in the late 1970s and early 1980s. Researchers applied guided tissue regeneration technology to immediate dental implants, and used it to guide bone regeneration around the implant, achieving ideal bone regeneration effects. Now, guided tissue regeneration technology has been widely used in alveolar surgery, periodontics, oral implantology, orthopedics and other fields. At present, there are many kinds of guided tissue regeneration membranes available clinically, which can be divided into two categories according to whether they can be absorbed: absorbable membranes and non-absorbable membranes; non-absorbable membranes must be removed by secondary surgery when used, which brings great ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/58A61L27/50A61L27/60
Inventor 刘少辉车七石李新霞
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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