Synthesis method of adipic acid dihydrazide

Abstract

The invention provides a synthesis method of adipic acid dihydrazide. The adipic acid dihydrazide is synthesized according to a two-step method. The synthesis method comprises the following steps: performing an esterification reaction on adipic acid and a mixture of methanol and ethanol under the catalysis of potassium hydrogen sulfate and concentrated sulfuric acid to synthesize dimethyl / diethyladipate, then performing an acylhydrazine reaction on the dimethyl / diethyl adipate and hydrazine hydrate to obtain the adipic acid dihydrazide. The obtained finished adipic acid dihydrazide product has the conversion rate of 98-99%; according to the synthesis method, the esterification reaction yield and the catalytic activity are greatly improved, and catalysts are easier and more convenient to recycle and can be reused for more times; the synthesis method is economical, practical, and convenient for industrial production.

Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis, in particular to a method for synthesizing adipic acid dihydrazide. Background technique

[0002] Adipate dihydrazide (ADH), a white crystalline solid, has a symmetrical molecular structure and is a bifunctional compound. ADH is a good cross-linking agent, which can be cross-linked with carbonyl groups. The typical cross-linking with hyaluronic acid is used in medicine, and the cross-linking with diacetone acrylamide is used in water-based resins. With the increasingly stringent restrictions on volatile organic substances in coatings by environmental regulations, in recent years, domestic and foreign scholars have conducted a lot of research on water-based coatings and related products have developed rapidly, and in many application fields, they have completely or partially replaced traditional coatings. Solvent-based coatings in the sense. It can be expected that with the improvemen...