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Chinese herbal composition for treating tinea pedis and vulvovaginal candidiasis

A technology of vaginal candidiasis and composition, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, diseases, etc., and can solve the problems of drug-resistant skin, irritation, liver and kidney toxicity, etc.

Active Publication Date: 2019-05-17
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oral and topical antifungal preparations are commonly used clinically, but oral fluconazole, itraconazole and other drugs have liver and kidney toxicity, and topical clotrimazole and nystatin are likely to cause drug resistance and local skin irritation symptoms

Method used

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  • Chinese herbal composition for treating tinea pedis and vulvovaginal candidiasis
  • Chinese herbal composition for treating tinea pedis and vulvovaginal candidiasis
  • Chinese herbal composition for treating tinea pedis and vulvovaginal candidiasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0222] Embodiment 1 (lotion):

[0223] 1. Prescription

[0224] 1900g of cloves, 1500g of patchouli, 2100g of coptis, 1600g of gentian, 1400g of basil, 300g of dried alum, 1100g of mint, 100g of borneol (10kg in total).

[0225] 2. Preparation method

[0226] (1) Weigh the crude drug according to the above prescription, add water to cover 10 cm of the drug surface, soak for 1 hour and decoct 3 times;

[0227] (2) Stir fry for 60 minutes after the first boil, 45 minutes after the second boil, and 45 minutes after the third boil, and collect the decoction respectively;

[0228] (3) Combine the decoctions, concentrate to 50-55°C to a concentrated solution with a relative density of 1.10, let it cool at room temperature, sink with 95% ethanol alcohol until the alcohol content is 60%, leave it for 48 hours, filter, and reclaim the ethanol to Concentrated into lotion to 10L (containing 1g / mL crude drug);

[0229] (4) Refrigerate and store, and finally pack into 100-120ml / bottle lo...

Embodiment 2

[0230] Embodiment 2 (cream)

[0231] 1. Prescription

[0232] Cloves 2000g, Patchouli 1600g, Coptidis 2000g, Gentiana 1500g, Baibu 1500g, Alum 300g, Mint 1000g, Borneol 100g (10kg in total).

[0233] 2. Preparation method

[0234] (1) Weigh the crude drug according to the above prescription, add water to cover 10 cm of the drug surface, soak for 1 hour and decoct 3 times;

[0235] (2) Stir fry for 60 minutes after the first boil, 45 minutes after the second boil, and 45 minutes after the third boil, and collect the decoction respectively;

[0236] (3) Combine the decoctions, concentrate to a concentrated solution with a relative density of 1.10, let cool at room temperature, sink with 95% ethanol alcohol until the alcohol content is 60%, let stand for 48 hours, filter, and recover the ethanol until exhausted;

[0237] (4) Concentrate into a cream (containing 4 g / mL of crude drug) by adding auxiliary materials, store in cold storage, and finally pack into creams of 15-20 g / b...

Embodiment 3

[0238] Embodiment 3 (suppository)

[0239] 1. Prescription

[0240] 2100g of cloves, 1700g of patchouli, 1900g of coptis, 1400g of gentian, 1600g of basil, 200g of dried alum, 1000g of mint, and 100g of borneol (10kg in total).

[0241] 2. Preparation method

[0242] (1) Take the crude drug according to the weight ratio of the prescription, add water to the surface of the medicine for 10 cm, soak it for 1 hour and decoct it for 3 times;

[0243] (2) Stir fry for 60 minutes after the first boil, 45 minutes after the second boil, and 45 minutes after the third boil, and collect the decoction respectively;

[0244] (3) Combine the decoctions, concentrate to a concentrated solution with a relative density of 1.10, let cool at room temperature, sink with 95% ethanol alcohol until the alcohol content is 60%, let stand for 48 hours, filter, and recover the ethanol until exhausted;

[0245] (4) Add excipients and concentrate to form an extract (containing 4 g / mL of crude drug), sto...

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Abstract

The invention discloses a Chinese herbal composition for treating tinea pedis and vulvovaginal candidiasis. The Chinese herbal composition consists of active ingredients and medically acceptable auxiliary materials, wherein the active ingredients are aqueous extracts prepared from the following raw materials including, by weight, 19-21 parts of cloves, 15-17 parts of patchouli, 19-21 parts of rhizoma coptidis, 14-16 parts of radix geutianae, 14-16 parts of radix stemonae, 2-4 parts of dried alum, 9-11 parts of mint and 0.5-1.5 parts of borneol. The herbal composition can be a lotion or a suppository or a cream for external use. It is proved by clinical verification that the herbal composition has the advantages of being accurate in treatment effect, capable of rapidly relieving symptoms and high in safety.

Description

technical field [0001] The present invention relates to medical preparations, in particular to pharmaceutical preparations containing undetermined structures from plants. Background technique [0002] The diseases treated by the present invention are mainly: tinea pedis and vulvovaginal candidiasis. [0003] Mycosis can be simply divided into superficial mycosis and deep mycosis according to its invasion site. Superficial mycosis mainly refers to the infection caused by fungal invasion of the epidermis, mucous membrane, nail plate and hair. Superficial mycosis is one of the important diseases in dermatology, among which tinea pedis and vulvovaginal candidiasis are one of the most common clinical diseases. [0004] Tinea pedis refers to a fungal skin infection of the foot caused by dermatophytes, mainly involving the toes, between the toes and the lateral margins, and can affect the dorsum of the foot and the ankle in severe cases. The pathogenic bacteria of tinea pedis ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P17/00A61P31/10A61P15/02A61K33/06A61K31/045
Inventor 范瑞强陈信生袁娟娜谢婷袁小红莫冬冬
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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