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High-suction type strong bacteriostatic dressing and preparation method thereof

A high-absorbing, high-absorbing technology, applied in the field of medicine, can solve the problems of small antibacterial range and weak antibacterial effect, and achieve the effects of high absorption capacity, strong inhibitory effect, and rapid absorption.

Active Publication Date: 2019-05-17
SHENZHEN TSINGHUA YUANXING NANO MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its antibacterial range is small. For burn wound infection, etc., the wound surface is mainly dominated by Acinetobacter baumannii, accounting for 39%, followed by Proteus mirabilis and Pseudomonas aeruginosa, both of which are 20%. The chitosan-silver composite dressing has little antibacterial effect on this type of wound

Method used

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  • High-suction type strong bacteriostatic dressing and preparation method thereof
  • High-suction type strong bacteriostatic dressing and preparation method thereof
  • High-suction type strong bacteriostatic dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, high suction type, strong antibacterial dressing

[0021] Obtained after electrospinning from a spinning solution, the spinning solution contains an imbibition composition composed of two kinds of hydroxyethyl chitosan with different degrees of substitution and an antibacterial composition, and the imbibition composition comprises a degree of substitution 0.85 hydroxyethyl chitosan and a substitution degree of 0.3 hydroxyethyl chitosan, the mass ratio of the two is 1:0.05; the antibacterial composition contains silver sulfate and surfactant, and the mass ratio of the two is 1 : 0.2; wherein the inhalation composition accounts for 30% of the total mass of the dressing, and the antibacterial composition accounts for 3% of the total mass of the dressing.

[0022] Preparation:

[0023] A) hydroxyethyl chitosan is dissolved in 1.0wt% acetic acid solution to prepare hydroxyethyl chitosan solution, mixed with 4000ppm antibacterial composition aqueous solution, a...

Embodiment 2

[0025] Embodiment 2, high suction type, strong antibacterial dressing

[0026] Obtained after electrospinning from a spinning solution, the spinning solution contains an imbibition composition composed of two kinds of hydroxyethyl chitosan with different degrees of substitution and an antibacterial composition, and the imbibition composition comprises a degree of substitution 0.85 hydroxyethyl chitosan and a substitution degree of 0.3 hydroxyethyl chitosan, the weight ratio of the two is 1:0.01; the antibacterial composition contains silver sulfate and surfactant, the weight ratio of the two is The ratio is 1:0.5; wherein the absorbent composition accounts for 25% of the total mass of the dressing, and the antibacterial composition accounts for 2.5% of the total mass of the dressing.

[0027] The preparation method is shown in Example 1.

Embodiment 3

[0028] Embodiment 3, high suction type, strong antibacterial dressing

[0029] Obtained after electrospinning from a spinning solution, the spinning solution contains an imbibition composition composed of two kinds of hydroxyethyl chitosan with different degrees of substitution and an antibacterial composition, and the imbibition composition comprises a degree of substitution 0.85 hydroxyethyl chitosan and a substitution degree of 0.3 hydroxyethyl chitosan, the weight ratio of the two is 1:0.1; the antibacterial composition contains silver sulfate and surfactant, the weight ratio of the two is The ratio is 1:0.4; wherein the absorbent composition accounts for 40% of the total mass of the dressing, and the antibacterial composition accounts for 5% of the total mass of the dressing.

[0030] The preparation method is shown in Example 1.

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Abstract

The invention relates to the technical field of medicine, in particular to a high-suction type strong bacteriostatic dressing and a preparation method thereof. The dressing is obtained by conducting electrospinning on a spinning solution comprising an absorbent composition and an antimicrobial composition composed of hydroxyethyl chitosan with two different degrees of substitution. The dressing has the advantages of achieving high suction permeability and being capable of quickly absorbing the wound exudates. The weight of the dressing can reach 50 times the original weight after water absorption, and the dressing has a strong inhibition effect on various infectious bacteria of the wound surface. Compared with the prior art, the dressing has the significant progress.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a high-suction and strong antibacterial dressing and a preparation method thereof. Background technique [0002] Chitosan is especially suitable for absorbable surgical sutures in the medical field due to its biodegradability, broad-spectrum antibacterial properties, non-antigenicity and good biocompatibility, hemostasis and wound healing. Various tissue engineering scaffold materials such as threads, wound dressing and hemostatic materials. Among them, when used as a dressing, it has good air permeability and compliance, and has received widespread attention. However, many years of clinical trials have proved that this kind of dressing still has the phenomenon of slow absorption of wound exudate and small absorption during use, which makes the dressing not effective when used on bleeding wounds and burn wounds . [0003] Secondly, in order to improve the antibacterial proper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/46
Inventor 张舒玥高培军刘龙清蹇明丽李爽
Owner SHENZHEN TSINGHUA YUANXING NANO MATERIAL CO LTD