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Preparation method of protective wound dressing

A wound dressing and protective technology, applied in the field of medicine and health, to achieve the effect of simple and easy preparation method, reasonable design and good air permeability

Inactive Publication Date: 2021-07-13
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dressing prepared by it has the characteristics of high water absorption capacity and spectrum antibacterial ability, and has made significant progress compared with the existing technology. Benefits in deposition

Method used

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  • Preparation method of protective wound dressing
  • Preparation method of protective wound dressing
  • Preparation method of protective wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] : a kind of protective wound dressing:

[0085] This embodiment provides a protective wound dressing, which is specifically obtained by electrospinning a spinning solution containing the following two-part composition:

[0086] - Composition I composed of β-cyclodextrin mixture and Morinda officinalis ethanol extract in a weight ratio of 100:0.012;

[0087] -Composition II consisting of modified coffee carbon nanoparticles and Fengyuan element in a weight ratio of 100:0.028,

[0088] - The dry matter weight ratio of composition I to composition II is 2.25:1.

[0089] The β-cyclodextrin mixture in composition I included chitosan / β-cyclodextrin complex and hydroxypropyl-β-cyclodextrin (HP-β-CD) at a weight ratio of 1:0.30.

[0090] The chitosan / β-cyclodextrin complex is prepared through the following steps:

[0091] -Modification: sequentially add sodium dihydrogen phosphate, citric acid, polyethylene glycol and β-cyclodextrin in a weight ratio of 1:10:5:44 into a suff...

Embodiment 2

[0108] : Another kind of protective wound dressing:

[0109] The formula of the protective wound dressing described in this example is basically the same as that of Example 1, the only difference is that no Morinda officinalis ethanol extract is added to the composition I of this example; and it is prepared according to the method described in Example 1 Protective wound dressing.

Embodiment 3

[0110] : Another kind of protective wound dressing:

[0111] The formula of the protective wound dressing described in this example is basically the same as that of Example 1, except that the β-cyclodextrin mixture of composition I of this example is pure β-cyclodextrin; and according to Example 1 The method produces a protective wound dressing.

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Abstract

The invention relates to the technical field of medicine and health, in particular to a protective wound dressing which is characterized in that the protective wound dressing is obtained by performing electrostatic spinning on a spinning solution containing the following two parts of compositions: a composition I consisting of a beta-cyclodextrin mixture and a morinda officinalis alcohol extract; a composition II consisting of modified coffee carbon nano particles and a fulgogen, wherein the beta-cyclodextrin mixture comprises a chitosan / beta-cyclodextrin compound and hydroxypropyl-beta-cyclodextrin, the weight ratio of the chitosan / beta-cyclodextrin compound to the hydroxypropyl-beta-cyclodextrin is 1: (0.25-0.33), and the hydroxypropyl-beta-cyclodextrin comprises hydroxypropyl-beta-cyclodextrin with the substitution degree of 4.55 and HP-beta-CD (Hydroxypropyl-beta-cyclodextrin) with the substitution degree of 7.76. The dressing has relatively high imbibition capacity and strong antibacterial capacity, can rapidly heal wounds, prevent scar hyperplasia and reduce pigmentation near the wounds, and has the effects of removing scars and whitening while cooperatively and rapidly healing the wounds.

Description

[0001] Original application number: 2020102077658, name: preparation method of protective wound dressing, application date: 2020.03.23. technical field [0002] The invention relates to the technical field of medicine and hygiene, in particular to a preparation method of a protective wound dressing. Background technique [0003] The skin is an important organ of the human body. It plays a role in controlling body temperature, preventing infection and loss of body fluids, immunity and sensing. Due to trauma, abrasions, skin ulceration and burns, etc., it may cause extensive damage to the skin, and severe trauma may even threaten life or cause disability. The wound healing process mainly includes platelet aggregation, blood coagulation, fibrin formation, inflammatory response, keratinocyte proliferation and regeneration, damaged tissue repair and remodeling. At present, the measures to promote wound healing mainly include skin transplantation, external application of cytokine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/20A61L15/40A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/28A61L15/40A61L15/44A61L15/46A61L2300/104A61L2300/30A61L2300/45C08L5/16C08L5/08
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司