Method for preparing medical collagen sponge

A collagen sponge and a technology for preparation steps, which are applied in the field of preparation of medical collagen sponges, can solve the problems of limited effect of absorbing hemorrhage and exudate, water-absorbing swelling performance to be improved, poor anti-infection performance, etc., so as to improve medical performance and Physiological activity, the effect of improving solubility and degradability, improving flexibility and absorbency

Inactive Publication Date: 2018-12-21
FOSHAN SENANG BIO TECH CO LTD
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Problems solved by technology

[0008] The main technical problem to be solved by the present invention is to provide a medical sponge with poor antibacterial and anti-infection performance, limited effect of absorbing bleeding and exudate when used for external application to treat wounds, and improvement in water absorption and swelling performance. Preparation method of collagen sponge

Method used

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  • Method for preparing medical collagen sponge

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[0026]Take 6-10g of sodium alginate and add it to a beaker filled with 200-250mL of deionized water, stir with a magnetic stirrer at a speed of 500-550r / min until the sodium alginate dissolves, and obtain a mass fraction of 2-4% alginic acid Sodium solution, dissolve 3-4g of sodium periodate in 10-12g of deionized water to obtain an oxidation solution; put the above-mentioned oxidation solution into a three-necked flask with a dropping funnel and a stirrer, start the stirrer, and use 300- Start stirring at a speed of 500r / min, then put the above-mentioned sodium alginate solution into the dropping funnel, add the sodium alginate solution dropwise into the three-necked flask at a dropping rate of 4-6mL / min, after the addition is completed, put the three-necked Place the flask under light-proof conditions, and react at room temperature for 20-24 hours to obtain oxidized sodium alginate; add 4-5 mL of ethylene glycol to the above-mentioned oxidized sodium alginate, stop the reacti...

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Abstract

The invention discloses a method for preparing a medical collagen sponge, and relates to the technical field of medical biomaterial preparation. Main chemical components of a spider web are glycine, alanine and a small part of serine, added with other amino acid monomer protein molecular chains. Because sodium alginate is easily soluble in water, is a hydrophilic polymer, can absorb water and swell in a neutral aqueous solution, and has a strong water holding capacity, sodium alginate is partially oxidized by using sodium periodate to obtain oxidized sodium alginate containing aldehyde group.According to the method, the rigidity of the chain is reduced. Because of the introduction of the active group (the aldehyde group), the partially oxidized sodium alginate is chemically crosslinked with a polymer compound having a group such as an amino group to form a hydrogel. A collagen membrane is doped with degummed bamboo fiber, and pectin and lignin of the bamboo fiber are separated by hydrolysis after degumming, so as to form a bamboo fiber with an ultra-fine millipore structure. The flexibility and permeability of the collagen sponge are improved, and the application prospect is wide.

Description

technical field [0001] The invention discloses a method for preparing a medical collagen sponge, belonging to the technical field of medical biological material preparation. Background technique [0002] Medical collagen sponge is a commonly used medical consumable in surgery. It can act as a filler, quickly stop bleeding, prevent adhesion, accelerate wound healing, etc., and reduce the prevention of postoperative complications. It is widely used in neurosurgery, orthopedics, gynecology, general surgery, operating room, etc. [0003] Collagen is an extracellular protein, which is a fibrous protein twisted into a helical shape by three peptide chains. Collagen is the most abundant protein in the human body, accounting for more than 30% of the total protein in the body. Existing in almost all tissues, it is an extracellular matrix protein that exists in the form of insoluble fibers and has high tensile strength. It is very important for the formation of animal and human skin,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/00
CPCA61L24/001A61L24/0036A61L24/0042A61L24/08A61L24/102A61L2400/04C08L5/04C08L5/08
Inventor 胡次兵章红英王素香
Owner FOSHAN SENANG BIO TECH CO LTD
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