A temperature/pH responsive carboxylated nano hydrogel and its preparation method
A nano-hydrogel, dual-response technology, applied in the field of nano-materials and anti-tumor, can solve the problem of paclitaxel being difficult to dissolve in water
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Embodiment 1
[0053] First, the nano-hydrogel was synthesized by miniemulsion polymerization, and 0.129g NIPAM, 0.008g PAA and 0.039g SDS were weighed and dissolved in 40ml distilled water, which was recorded as water phase 5. Weigh 0.079g MAPEG and 0.019g DVB and dissolve it in 3ml DMSO, and record it as oil phase 6. Add the oil phase 6 to the water phase 5 drop by drop with a peristaltic pump (mechanical stirring, 800rpm, 2.5ml / h), and ultrasonicate for 1.5h. Then cover the bottom of a 2000mL large beaker with physiological ice cubes, put the above emulsion into a 250mL small beaker and put it in the large beaker, pad it tightly with soft foam around it, clean the probe of the ultrasonic breaker (200W) with alcohol in advance, and then ultrasonic Fine emulsification for 5 minutes to obtain a stable fine emulsion. Then pour the fine emulsion into the three-necked bottle, pre-pass N 2 For about 20 minutes, under mechanical stirring, the temperature was raised to 60°C and 0.0075g KPS was a...
Embodiment 2
[0057] Firstly, the nano-hydrogel was synthesized by miniemulsion polymerization, and 0.129g NIPAM, 0.018g PAA and 0.042g SDS were weighed and dissolved in 45ml distilled water, which was recorded as water phase 9. Weigh 0.085g MAPEG and 0.0421g DVB and dissolve in 4ml DMSO, and record it as oil phase 10. Add the oil phase 10 to the water phase 9 drop by drop with a peristaltic pump (mechanical stirring, 900 rpm, 3ml / h), and ultrasonicate for 2 hours. Then cover the bottom of a 2000mL large beaker with physiological ice cubes, put the above emulsion into a 250mL small beaker and put it in the large beaker, pad it tightly with soft foam around it, clean the probe of the ultrasonic breaker (250W) with alcohol in advance, and then ultrasonic Fine emulsification for 8 minutes to obtain a stable fine emulsion. Then pour the fine emulsion into the three-necked bottle, pre-pass N 2 After about 25 minutes, under mechanical stirring, the temperature was raised to 65°C and 0.008g KPS ...
Embodiment 3
[0060] First, the nano-hydrogel was synthesized by miniemulsion polymerization, and 0.129g NIPAM, 0.029g PAA and 0.045g SDS were weighed and dissolved in 50ml distilled water, which was recorded as the water phase 13. Weigh 0.091g of MAPEG and 0.022g of DVB and dissolve in 5ml of DMSO, and record it as oil phase 14. The oil phase 14 was added dropwise to the water phase 13 with a peristaltic pump (mechanical stirring, 1000 rpm, 3.5ml / h), and ultrasonicated for 2.5 hours. Then cover the bottom of a 2000mL large beaker with physiological ice cubes, put the above emulsion into a 250mL small beaker and put it in the large beaker, pad it tightly with soft foam around it, clean the probe of the ultrasonic breaker (300W) with alcohol in advance, and then ultrasonic Fine emulsification for 10 minutes to obtain a stable fine emulsion. Then pour the fine emulsion into the three-necked bottle, pre-pass N 2 About 30min, under mechanical stirring, the temperature was raised to 70°C and 0...
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