Elastic deformable skull base bone defect repairing bracket and preparation method thereof

Abstract

The invention discloses an elastic deformable skull base bone defect repairing bracket. The elastic deformable skull base bone defect repair bracket includes a bracket body, the bracket body includesa functional layer and a base layer, the functional layer includes a top layer and a bottom layer, the top layer and the bottom layer are connected by the base layer, wherein the functional layer hasa first porous structure, which is mainly prepared from a first polymer material, and the first polymer material accounts for 85% to 100% of the mass of the functional layer; the base layer has a second porous structure prepared by mixing a calcium phosphate-based biomaterial and a second polymer material, and the mass of the calcium phosphate-based biomaterial accounts for 60 wt% to 80 wt% of that of the base layer. The bracket of the invention has both a certain elasticity and expansion function, can be compressed and folded, is convenient for implantation into an injured area, is easy to operate, can reduce intraoperative surgical incision, and reduces the degree of injury to patients. The bracket of the invention has good effect and clinical application value in repairing the defect ofthe skull base bone.

Description

technical field [0001] The application belongs to the field of medical devices, and in particular relates to an elastically deformable skull base bone defect repair bracket and a preparation method thereof. Background technique [0002] The bottom of the cranial cavity is called the skull base. Because most of the connections between the human brain and the outside world are made through the base of the skull, there are a large number of openings in the base of the skull. The structure of the base of the skull is extremely complex, and the bone thickness is uneven. It is usually necessary to grind away a large amount of bone, and if the repair of these irregular bone is not complete, it will cause the structural loss of the skull base and increase the risk of postoperative cerebrospinal fluid leakage, intracranial and intracranial infection, and brain tissue swelling. Therefore, skull base reconstruction is an important part of skull base tumor surgery. [0003] For the rep...

AI Technical Summary

Problems solved by technology

Autologous materials such as fat, periosteum, ribs, etc. are implanted into the defect site as filling materials. They have good histocompatibility and no rejection, and have always been considered as the preferred material. However, autologous materials are likely to cause severe deformities in the donor site and secondary operations. Injury and legacy donor site complications with limited tissue sources

Clinically, the existing biomaterials for skull base bone repair are mainly made of titanium, but due to the complex and irregular structure of the skull base, it is difficult to accurately match the defect site.

And for the defect at the base of the skull, due to the deep anatomical location and complex structure, the size of the incision should be fully considered during the operation to avoid expanding the surgical damage to the patient. The existing stents usually have limited deformability. A new elastically deformable scaffold for skull base bone defect repair is of great significance

[0004] Although CN105324336A discloses a skull base bone repair material, which is wrapped by two layers of biofilms, shape memory alloy stents, polymer material stents or ceramic material stents, but the memory alloy stents in this material involve the implantation of metal materials, In the acquisition of medical imaging scans, there may be a problem that the interaction between the magnetic field and the metal implant may cause damage to the patient; the pure polymer material scaffold lacks osteoinductive repair performance and the simple ceramic material scaffold has poor elasticity

Furthermore, the sources of animal-derived biofilms are limited, and the deantigenization step in the preparation process is complex, requiring the use of more toxic organic reagents, and the efficiency is low. Only the cross-linking and fixing process in the biofilm treatment will consume 2 ~8 days

Finally, the combination between the biofilm of the skull base repair material and the intermediate scaffold is not firm, and it is prone to delamination or displacement

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