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Preparation method of carboxymethyl chitosan composite anticoagulation biological material

A technology of carboxymethyl chitosan and biomaterials, which is applied in the field of preparation of carboxymethyl chitosan composite anticoagulant biomaterials, can solve the problem of limited material surface designability, inability to realize medical device modification, and inability to meet medical requirements. It is suitable for large-scale industrial application, the material is mild and non-irritating, and the effect of strong practicability is achieved.

Inactive Publication Date: 2019-06-18
赵延延
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these surface modification methods generally have weaknesses such as solvent toxicity, complicated preparation process, and poor controllability, which not only greatly limit the designability of the material surface, but also cannot realize the modification of medical devices with complex geometric shapes. Meet the needs of the rapid development of medical devices

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) 20 parts of polyurethane, 10 parts of polylactic acid, 3 parts of polyethylene glycol carbonate, 1 part of dimethyl sulfoxide, 6 parts of carboxymethyl chitosan, tetraisopropyl bis (dilauryl phosphite ) 2 parts of titanate were added into an ultrasonic oscillator for dispersion and coupling, and the obtained solution was sieved and sorted for later use, wherein the ultrasonic power was 250KW, ultrasonic oscillation was 30min, and the sieve aperture was 2000 mesh;

[0025] (2) Add the solution of step (1) into the vacuum reactor, heat to 50°C, then add 1 part of glass fiber, 3 parts of phospholipid, 3 parts of cellulose acetate, and 1 part of polycaprolactone, and then the temperature rises again To 190-200°C, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 2h, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0026] (3) Inject the reaction solution of step (2) into the in...

Embodiment 2

[0032] (1) Mix 22 parts of polyurethane, 11 parts of polylactic acid, 4 parts of polyethylene glycol carbonate, 2 parts of dimethyl sulfoxide, 7 parts of carboxymethyl chitosan, bis(dioctyl pyrophosphoryl) oxygen Add 3 parts of titanium acetate to an ultrasonic oscillator for dispersion and coupling, and the obtained solution is sieved and sorted for later use, wherein the ultrasonic power is 250KW, ultrasonic oscillation is 40min, and the sieve aperture is 2000 mesh;

[0033] (2) Add the solution of step (1) into the vacuum reactor, heat to 50°C, then add 2 parts of glass fiber, 4 parts of phospholipid, 4 parts of cellulose acetate, and 1 part of polycaprolactone, and then the temperature rises again To 190-200°C, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 3 hours, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0034] (3) Inject the reaction solution of step (2) into the in...

Embodiment 3

[0040] (1) 24 parts of polyurethane, 13 parts of polylactic acid, 7 parts of polyethylene glycol carbonate, 2 parts of dimethyl sulfoxide, 9 parts of carboxymethyl chitosan, isopropyl tri(isostearyl) titanium Add 4 parts of acid ester to an ultrasonic oscillator for dispersion and coupling, and the obtained solution is sieved and sorted for future use, wherein the ultrasonic power is 250KW, ultrasonic oscillation is 45min, and the sieve aperture is 2000 mesh;

[0041] (2) Add the solution of step (1) into the vacuum reactor, heat to 50°C, then add 2 parts of glass fiber, 4 parts of phospholipid, 7 parts of cellulose acetate, and 2 parts of polycaprolactone, and then the temperature rises again To 190-200°C, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 4h, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0042] (3) Inject the reaction solution of step (2) into the injection moldi...

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Abstract

The invention discloses a preparation method of a carboxymethyl chitosan composite anticoagulation biological material. According to the process, the carboxymethyl chitosan composite anticoagulation biological material is prepared from raw materials such as polyurethane, polylactic acid, polyethylene glycol carbonate, dimethyl sulfoxide, carboxymethyl chitosan, glass fiber, phospholipid, celluloseacetate fiber, polycaprolactone and the like through ultrasonic oscillation dispersion, sieving and sorting, vacuum heating reaction, injection molding and mold pressing, cooling and fixation, ultrasonic cleaning, adsorption equilibrium by positive and negative electrolyte water solutions, washing and airing, nitrogen protection and curing and other steps. The prepared carboxymethyl chitosan composite anticoagulation biological material is mild, non-irritating, good in anticoagulation function, `free from solvent toxicity and suitable for being applied to multiple medical blood tube materialsand auxiliary materials.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method of carboxymethyl chitosan composite anticoagulant biomaterials. Background technique [0002] Anticoagulant biomaterials are key materials for the manufacture of various artificial organs and interventional medical devices that come into contact with blood. Therefore, since the upsurge of developing artificial organs and cardiovascular interventional medical devices in the late 1940s, anticoagulant biomaterials have been an international research hotspot in biomaterials. The interaction of blood with materials mainly occurs at their interfaces, so the anticoagulant properties of biomaterials strongly depend on their surface features. Therefore, in addition to designing and preparing various new biological materials with excellent performance, modifying the surface of traditional materials is also an effective way to improve their anticoagulant propertie...

Claims

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Application Information

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IPC IPC(8): A61L33/06A61L33/02A61L33/00A61L33/08
Inventor 赵延延侯林孟国霞
Owner 赵延延
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