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3D printing method based on hydroxyapatite-zirconium dioxide artificial bone

A technology of hydroxyapatite and zirconium dioxide, which is used in medical science, prosthesis and other directions, can solve the problems of uncomplicated outline and irregular internal pore structure, saving time and good biocompatibility. and biological activity, the effect of increasing the contact surface area

Inactive Publication Date: 2019-06-28
HANGZHOU DIANZI UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide an artificial bone made of hydroxyapatite and zirconia composite material using 3D printing technology to solve the problems of irregular internal pore structure and difficult to complicate the outline of the mold method in the current artificial bone manufacturing. Methods

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  • 3D printing method based on hydroxyapatite-zirconium dioxide artificial bone

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Embodiment Construction

[0013] The following is attached figure 1 The present invention is further described.

[0014] Such as figure 1 As shown, the present invention provides a method for preparing artificial bone with extrusion 3D printing technology, comprising the following steps:

[0015] 1. Prepare printing materials: The mass ratio of hydroxyapatite, silicon dioxide, polyvinyl alcohol, and citric acid in the prepared materials is 5:3:1:1. First, weigh an appropriate amount of powder according to the ratio, and weigh the poly Mix vinyl alcohol powder and distilled water in a water bath and heat it to 99°C for 1 hour to fully dissolve it, then cool it and put it in a freezer at minus 10°C for 6 hours, take it out and thaw it for 12 hours and repeat it three times to make a 10% hydrogel The glue is ready for use, weigh the hydroxyapatite and silica powder in proportion, add them to the mixer and mix them for 0.5 hours to make them evenly mixed, then mix them with polyvinyl alcohol hydrogel, an...

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Abstract

The invention discloses a 3D printing method based on a hydroxyapatite-zirconium dioxide artificial bone. The method comprises the steps that printing materials are prepared firstly, then a digital model is made, then printing is conducted, and finally printing post-processing is conducted, wherein the printing materials include hydroxyapatite, silica, polyvinyl alcohol and citric acid; particularly, polyvinyl alcohol powder and distilled water are subjected to mixing and water-bath heating, then cooled, put into a freezer, taken out and thawed to obtain hydrogel for use; hydroxyapatite and silica powder are weighed and added into a mixer to be mixed, then the mixture is mixed with polyvinyl alcohol hydrogel, stirring is conducted through a constant speed blender at a low speed, finally citric acid is added for stirring, and the composite printing material is obtained after standing and defoaming are conducted. The method has the advantages of being simple in process, high in yield, controllable in internal structure, low in cost, safe and reliable.

Description

technical field [0001] The invention relates to a preparation method of artificial bone made of hydroxyapatite-zirconia composite material, in particular to a preparation method using 3D printing technology. Background technique [0002] Hydroxyapatite is the main component of bones and teeth. It has good biological activity and compatibility. It has no immune and rejection reactions to tissues after implantation and can form a strong combination with bone tissue; As a bone tissue engineering material, apatite has poor elasticity and plasticity, high brittleness, and poor mechanical properties. Zirconium dioxide is a biologically inert material with high mechanical strength and fracture toughness. The introduction of zirconium dioxide into hydroxyapatite powder can improve the performance of hydroxyapatite ceramics, so that it has both good mechanical properties and Has certain biological activity. [0003] Che Qishi's CN201811113259 is to mix multi-component solid-phase p...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56C04B35/447C04B35/622
Inventor 龚友平葛安磊何志升王飞毕志凯陈慧鹏刘海强陈国金
Owner HANGZHOU DIANZI UNIV
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