Absorbable iron-based implantable device

Abstract

The invention relates to an absorbable iron-based implantable device. The absorbable iron-based implantable device comprises an iron-based matrix and an iron-promoting absorbent attached to the iron-based matrix. The iron-promoting absorbent is a polymer, and an iron-promoting absorbent molecular chain contains an antioxidant structural unit. An antioxidant is released gradually with gradual degradation or chain breaking of the iron-promoting absorbent and can play a role in promoting iron absorption.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to an absorbable iron-based implantable device. Background technique [0002] At present, absorbable implantable medical device materials mainly include degradable polymers and absorbable metal materials. Absorbable metal materials include magnesium-based alloys, iron-based alloys, zinc-based alloys and pure iron. Among them, iron-based alloys and pure iron have excellent mechanical properties comparable to those of permanent implanted medical metal materials such as stainless steel, cobalt-chromium alloy, and platinum-chromium alloy. Compared with other absorbable materials, smaller but Implanted medical devices with better mechanical properties can ensure better clinical operability and effectiveness. The ideal absorbable medical device design concept is to provide effective support during the recovery period of the lesion. After the lesion is cured, the absorbable imp...

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Problems solved by technology

In addition, if Fe(OH) 3 Solid corrosion products are aggregated together, and phagocytes can only contact the outermost layer of corrosion products, and the efficiency of swallowing and transporting solid corrosion products will become lower

Therefore, Fe(OH) 3 Solid corrosion products will be removed more slowly, resulting in longer absorption cycles

[0005] Aiming at the problems that the iron corrosion products are difficult to absorb in the body and the absorption cycle is long, the prior art adopts the method of adding antioxidants to promote the formation of soluble iron corrosion products, such as water-soluble polyphenols, tocopherols, sodium tripolyphosphate, etc., However, the above-mentioned antioxidants have the following problems: 1. Poor stability, the chemical properties are easy to change under light, oxygen-rich or specific pH conditions and thus lose the antioxidant effect; Dissolving in blood and water-based interstitial fluid leads to a large loss, and fat-soluble antioxidants are difficult to dissolve in water-soluble interstitial fluid, so the anti-oxidation effect is not good, and it is difficult to promote the corrosion product of iron with a higher solubility product Fe( Oh) 2 3. Most of these antioxidants are released quickly at the beginning, and iron-based alloy implantable medical devices usually start to corrode in about 3 months in order to ensure the stability of the mechanical properties in the early stage

Therefore, before the iron matrix is ​​corroded, the above-mentioned antioxidants have been consumed and have no effect on promoting iron absorption.