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Method for recycling acyclovir condensation by-products and solvents

A technology of by-products and solvents, which is applied in the field of recovery and utilization of acyclovir condensation reaction by-products and reaction solvents, can solve the problems of high consumption of sodium hydroxide, consumption of steam and electric energy, and high processing costs, so as to reduce consumption and facilitate Effects of preparation and elimination of waste water

Active Publication Date: 2019-07-05
HUBEI YITAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The consumption of sodium hydroxide in these treatment processes is high, and a large amount of waste water containing 2-6% sodium acetate, COD60000-150000 mg / L, and pH value 8-12 is produced. Treatment of up-to-standard discharge requires Fenton, neutralization, dilution, biochemical and other treatment processes, and the treatment cost is high. If you want to prepare sodium acetate from a sodium acetate solution containing 2 to 6%, because the concentration is too low, a large amount of steam and electricity are consumed, and the treatment cost high

Method used

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  • Method for recycling acyclovir condensation by-products and solvents

Examples

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Comparison scheme
Effect test

Embodiment 1

[0021] After drying the toluene, the sodium hydroxide (containing 150 kg of sodium hydroxide) settled at the bottom of the kettle was added to 800 L of the reclaimed water separated from the first batch of acid toluene washed with water for the first time to prepare a 15-20% sodium hydroxide solution. 3000L of acyclovir condensation reaction recovered acid toluene, stirred and neutralized for 50 minutes, allowed to stand for 40 minutes to separate layers, took the lower layer liquid and measured the pH value of 9.5 with extensive pH test paper, and separated the lower layer of saline phase 840L.

[0022] Add 800 L of reclaimed water separated from the second batch of acid toluene to the supernatant toluene, stir and wash for 30 minutes, let the layers stand for 30 minutes, and separate the lower aqueous phase. Add 800 L of reclaimed water separated from the previous batch of acid toluene to the supernatant liquid toluene for the third time washing and layering, stir and wash fo...

Embodiment 2

[0026] After drying the toluene, the sodium hydroxide (containing 150 kg of sodium hydroxide) settled at the bottom of the kettle was added to 800 L of the reclaimed water separated from the first batch of acid toluene washed with water for the first time to prepare a 15-20% sodium hydroxide solution. 3000L of acyclovir condensation reaction recovered acid toluene, stirred and neutralized for 40 minutes, allowed to stand for 30 minutes to separate layers, took the lower layer liquid and measured the pH value of 9.5 with extensive pH test paper, and separated the lower layer of saline phase 860L.

[0027] Add 800 L of recovered water separated from the second batch of acid toluene to the supernatant liquid toluene, stir and wash for 20 minutes, let stand for 20 minutes to separate the layers, and separate the lower aqueous phase. Add 800 L of reclaimed water separated from the third water washing and layering of the previous batch of acid toluene to the supernatant liquid toluen...

Embodiment 3

[0031] After drying the toluene, the sodium hydroxide (containing 150 kg of sodium hydroxide) that settled at the bottom of the kettle was added to 800 L of the recovered water separated from the first batch of acid toluene washed with water for the first time to prepare a 15-20% sodium hydroxide solution. 3000L of acyclovir condensation reaction recovered acid toluene, stirred and neutralized for 30 minutes, left to separate layers for 30 minutes, took the lower layer liquid and measured the pH value of 10 with extensive pH test paper, and separated the lower layer of saline phase 865L.

[0032] Add 800 L of reclaimed water separated from the second batch of acid toluene to the supernatant liquid toluene, stir and wash for 25 minutes, let the layers stand for 25 minutes, and separate the lower aqueous phase. Add 800 L of reclaimed water separated from the third water washing and layering of the previous batch of acid toluene to the supernatant liquid toluene, stir and wash for...

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Abstract

The invention discloses a method for recycling acyclovir condensation reaction by-products and solvents, which comprises the following steps of: neutralizing and recycling acetic anhydride in a next batch of toluene by using sodium hydroxide for toluene drying, so that consumption of the sodium hydroxide for recycling and treating the toluene is reduced; thoroughly removing sodium acetate and impurities in the recycled toluene by adopting a mode of multiple water washing and layering, so that the quality of the finally recycled toluene is guaranteed, and the quality of the recycled toluene meets the requirement of process use; utilizing the water washing and layering water gradient recycling to improve the concentration of the sodium acetate in the water washing and layering water; using the gradient recycling water as the solvent for alkali washing and neutralizing the sodium hydroxide, so that the concentration of the sodium acetate after the alkali washing is maximized, preparationof the sodium acetate is facilitated, and it is beneficial to reduce the cost of preparing the sodium acetate; repeat recycling of a mother solution generated by the preparation of the sodium acetate,so that generation of waste water is reduced; and utilizing the water washing and layering water gradient recycling by acid toluene, so that the generation of the waste water with high salinity and high COD is eliminated.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a method for recycling acyclovir condensation reaction by-products and reaction solvents. Background technique [0002] Acyclovir is a broad-spectrum antiviral drug. The main production process of its industrial production synthesis reaction is: acetylation of guanine to generate diacetylguanine, diacetylguanine and side chain condensation to generate diacetyl acyclovir, diacetylguanine Alkaline hydrolysis of acetyl acyclovir to produce acyclovir. The process of diacetylguanine and side chain condensation to generate diacetyl acyclovir uses toluene as solvent, the condensation reaction generates diacetyl acyclovir main product and acetic anhydride by-product, the reaction solution is cooled, diacetyl acyclovir Crystallization, separation by rejection and filtration, the by-product acetic anhydride exists in the mother liquor, and the mixed solu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/083C07C51/41C07C53/10C07D473/18
CPCC07C51/083C07C51/412C07D473/18C07C53/10
Inventor 吴晓宇郭良臣
Owner HUBEI YITAI PHARMA
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