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Phosphorus binding agent with MOFs structure and preparation method and application thereof

A phosphorus binder and reaction technology, applied in the field of phosphorus binders with MOFs structure and its preparation, to achieve the effects of reducing phosphorus content, good biocompatibility, and improving reaction efficiency

Active Publication Date: 2019-07-05
北京市中关村医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no research on MOFs as phosphorus binders for the treatment of hyperphosphatemia, etc.

Method used

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  • Phosphorus binding agent with MOFs structure and preparation method and application thereof
  • Phosphorus binding agent with MOFs structure and preparation method and application thereof
  • Phosphorus binding agent with MOFs structure and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] In this example, the phosphorus binder of MOFs structure was prepared by the following method

[0049] (1) In a polytetrafluoroethylene container, dissolve ferric chloride in deionized water, add trimesic acid and sodium acetate, and mix and react at 120°C for 24 hours, wherein the moles of ferric chloride, trimesic acid and sodium acetate The ratio is 1.5:1:2.5, centrifuged, washed with ethanol for 3 times, and freeze-dried to obtain Fe-MOFs with a particle size of 250nm;

[0050] (2) Disperse the obtained Fe-MOFs into a 70% ethanol solution with a mass fraction of 70%, the mass ratio of Fe-MOFs to ethanol solution is 1:2, add 2-hydroxypropyltrimethylammonium chloride, 2-hydroxypropyltrimethylammonium chloride The mass ratio of propyltrimethylammonium chloride to Fe-MOFs is 1:1.8, the pH value is adjusted to 6.5 with sodium hydroxide, heated to 75°C in a water bath, and after cationization reaction for 4 hours, it is centrifuged at a speed of 10000r / min 15min, washing...

Embodiment 2

[0052] In this example, the phosphorus binder of MOFs structure was prepared by the following method

[0053] (1) In a polytetrafluoroethylene container, dissolve ferric sulfate in deionized water, add 2-aminotrimellitic acid and hydrochloric acid, and mix and react at 150°C for 20 hours, wherein ferric sulfate, 2-aminotrimellitic acid and hydrochloric acid The molar ratio is 2:1.5:3, centrifuged, washed 3 times with ethanol, and freeze-dried to obtain Fe-MOFs with a particle size of 200nm;

[0054] (2) Dispersing the obtained Fe-MOFs into a mass fraction of 75% ethanol solution, the mass ratio of Fe-MOFs to ethanol solution is 1:1.5, adding 2,3-epoxypropyltrimethylammonium chloride, The mass ratio of 2,3-epoxypropyltrimethylammonium chloride to Fe-MOFs is 1:1.5, the pH value is adjusted to 7 with sodium hydroxide, and the water bath is heated to 80°C. After cationization reaction for 4 hours, the speed Centrifuge at 12000r / min for 10min, wash and freeze-dry to obtain the Fe-...

Embodiment 3

[0056] In this example, the phosphorus binder of MOFs structure was prepared by the following method

[0057] (1) In a polytetrafluoroethylene container, dissolve zinc nitrate in deionized water, add 2-aminoterephthalic acid and water, and mix and react at 110°C for 30 hours, wherein zinc nitrate, 2-aminoterephthalic acid and water The molar ratio is 1.6:1.2:2.7, centrifuged, washed with ethanol for 3 times, and freeze-dried to obtain Zn-MOFs with a particle size of 400nm;

[0058] (2) Disperse the obtained Zn-MOFs into a 65% ethanol solution by mass fraction, the mass ratio of Zn-MOFs to ethanol solution is 1:4, add 3-chloro-2-hydroxypropyl dodecyl dimethyl Ammonium chloride, the mass ratio of 3-chloro-2-hydroxypropyl dodecyl dimethyl ammonium chloride to Zn-MOFs is 1:2, the pH value is adjusted to 6 with sodium hydroxide, and heated to 70 in a water bath ℃, after cationization reaction for 5 hours, centrifugation at 8000r / min for 20 minutes, washing and freeze-drying to obt...

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Abstract

The invention provides a phosphorus binding agent with a MOFs structure and a preparation method and application thereof. The preparation method comprises the following steps of: cationizing the surface of a metal-based organic framework material to obtain the phosphorus binding agent with the MOFs structure. According to the preparation method, a functional group is introduced into an organic ligand or an active component is introduced by using the MOFs as a subjective environment; for example, Lewis acid sites rich in the surface of the MOFs can be used as an inorganic oxyacid root anion toprovide ideal coordination adsorption sites so as to synthesize the cationized MOFs material, and the prepared cationic MOFs material with cationic degree of 25-35% has the characteristics of no toxicity, good biocompatibility and the like; and the prepared cationic MOFs material can be combined with phosphate ions to reduce the phosphorus content in a human body so as to treat hyperphosphatemia.

Description

technical field [0001] The invention belongs to the field of biological functional materials, and relates to a phosphorus binder with a MOFs structure and a preparation method and application thereof. Background technique [0002] Hyperphosphatemia refers to a pathological state in which the blood phosphate content increases beyond the normal level, and it is a kind of phosphorus metabolism disorder. Acute and chronic renal insufficiency is the most common cause of hyperphosphatemia. At the same time, some secondary hyperparathyroidism causes increased release of phosphorus in bone, and the application of phosphorus-containing laxatives or enemas can cause phosphorus to enter the extracellular space. Fluid increase, will lead to varying degrees of hyperphosphatemia. Hyperphosphatemia is the core link leading to chronic kidney disease, which can lead to long-term bone pain in patients, and severe muscle pain can lead to skin necrosis, infection and even disability. Hyperpho...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61P3/12
CPCA61P3/12C08G83/008
Inventor 富大鹏张启蒙
Owner 北京市中关村医院
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