Efficient bacteriostatic drug composition and a preparation method and application thereof

A composition and drug technology, applied in the field of medicine, to achieve the effects of inhibiting pathogenic bacteria, ensuring activity, and optimizing the preparation method

Active Publication Date: 2019-07-09
YUAN INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned patents, chlorhexidine is used in the preparation of soap to prevent bacterial infection, and it has not been found that chlorhexidine is used in medicine to prepare a kind of skin disease that can treat bacterial infections.

Method used

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  • Efficient bacteriostatic drug composition and a preparation method and application thereof
  • Efficient bacteriostatic drug composition and a preparation method and application thereof
  • Efficient bacteriostatic drug composition and a preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Antibacterial pharmaceutical composition and its preparation

[0025] Composition: 6 parts chlorhexidine acetate, 80 parts sulfur, 6 parts allantoin, 160 parts 15# white oil, 60 parts 340B-emulsifier, 60 parts A165 emulsifier, 60 parts 16-18 alcohol, 100 glycerin , 200 parts of propylene glycol, 2 parts of methyl paraben, 1 part of propyl paraben, 80 parts of isopropyl myristate, 40 parts of stearic acid, 20 parts of silicone oil, 20 parts of azone, 1200 parts of purified water.

[0026] Preparation:

[0027] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat to 70°C to obtain the water phase;

[0028] (2) Prepare the oil phase: mix 340B-emulsifier, 16-18 alcohol, methyl paraben, propyl paraben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Mix isopropyl acid and stir, and heat to 70°C to obtain the oil phase;

[0029] (3) After mixing the water phase and the oil phase with vacuum suction, homogenize...

Embodiment 2

[0031] Example 2 Antibacterial pharmaceutical composition and its preparation

[0032] Composition: 4 parts chlorhexidine acetate, 70 parts sulfur, 4 parts allantoin, 150 parts 15# white oil, 50 parts 340B-emulsifier, 50 parts A165 emulsifier, 50 parts 16-18 alcohol, 80 glycerin , 190 parts of propylene glycol, 1 part of methyl paraben, 0.5 parts of propyl platinum, 70 parts of isopropyl myristate, 30 parts of stearic acid, 10 parts of silicone oil, 10 parts of Azone, 1000 parts of purified water.

[0033] Preparation:

[0034] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat to 60°C to obtain the water phase;

[0035] (2) Prepare the oil phase: mix 340B-emulsifier, 16-18 alcohol, methyl paraben, propyl paraben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Mix isopropyl acid and stir, heat up to 60°C to obtain the oil phase;

[0036] (3) After mixing the water phase and the oil phase with vacuum suction, homogeniz...

Embodiment 3

[0038] Example 3 Antibacterial pharmaceutical composition and its preparation

[0039] Composition: 8 parts chlorhexidine acetate, 100 parts sulfur, 8 parts allantoin, 180 parts 15# white oil, 70 parts 340B-emulsifier, 70 parts A165 emulsifier, 70 parts 16-18 alcohol, 120 glycerin , 220 parts of propylene glycol, 3 parts of methyl paraben, 3 parts of propyl paraben, 100 parts of isopropyl myristate, 50 parts of stearic acid, 30 parts of silicone oil, 30 parts of Azone, 1500 parts of purified water.

[0040] Preparation:

[0041] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat to 80°C to obtain the water phase;

[0042] (2) Prepare the oil phase: mix 340B-emulsifier, 16-18 alcohol, methyl paraben, propyl paraben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Mix isopropyl acid and stir, and heat to 80°C to obtain the oil phase;

[0043] (3) After mixing the water phase and the oil phase with vacuum suction, homogen...

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PUM

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Abstract

The invention provides an efficient bacteriostatic drug composition. Three components, namely chlorhexidine acetate, sulfur and allantoin, serve as the active ingredients of the composition, pathogenic bacteria parasitic on the skin can be effectively inhibited through the synergistic effects of the three components, and the composition especially has a significant inhibition effect on staphylococcus aureus, escherichia coli and candida albicans. At the same time, by strictly controlling the process temperature in the preparation process, the composition can effectively ensure the drug activity, give play to the synergistic effects of the components, and enhance the bacteriostatic effect.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a high-efficiency antibacterial composition and a preparation method and application thereof. Background technique [0002] As the largest organ of the human body, the skin plays an important role in sensing external stimuli, regulating body temperature, regulating water evaporation loss, protecting various tissues and organs in the body from physical and chemical damage, and resisting the invasion of pathogenic microorganisms. The skin participates in the metabolic process of the human body, which is of great significance for maintaining the stability of the human body environment and maintaining the body's normal physiological functions. The skin area of ​​an adult is about 1.8m 2 , There are a large number of microorganisms living on the skin, up to 10 7 Pcs / cm -2 . These microbial flora are closely related to human skin and human health. However, in recent years, as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K31/155A61K31/4166A61P31/04A61P31/10A61P17/00A61P17/10A61P29/00
CPCA61K31/155A61K31/4166A61K33/04A61P17/00A61P17/10A61P29/00A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 王若研田德海张军史跃满黄炎冯雪陈晓彤李建石佳袁一鸣何爱琳王翼超刘爽
Owner YUAN INT GROUP
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