Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug-loaded polymer micelle for treating cardiovascular diseases and preparation method and application thereof

A technology of drug-loaded polymers and polymer glues, which can be used in cardiovascular system diseases, drug combinations, and pharmaceutical formulations. narrow effect

Inactive Publication Date: 2019-07-12
SOUTHWEST JIAOTONG UNIV
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, when bare metal stents are implanted into patients with atherosclerosis, not only will there be inflammatory reactions, but also complications such as intravascular restenosis and late thrombosis will occur in the late stage, which hinders the development of stents.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug-loaded polymer micelle for treating cardiovascular diseases and preparation method and application thereof
  • Drug-loaded polymer micelle for treating cardiovascular diseases and preparation method and application thereof
  • Drug-loaded polymer micelle for treating cardiovascular diseases and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] The embodiment of the present invention also provides a preparation method of the above-mentioned drug-loaded polymer micelles for treating cardiovascular diseases, the preparation method comprising the following steps:

[0035] Micellar extraction of a novel hydrogen sulfide-releasing form of aspirin using a solution containing polymeric micelles followed by isolation.

[0036] The preparation method of the polymer micelle comprises: dissolving the polymer in an organic solvent to obtain a polymer solution; under ultrasonic conditions, adding the polymer solution dropwise into deionized water, followed by dialysis with deionized water, through Dried to obtain polymer micelles;

[0037] Preferably, the organic solvent is selected from at least one of DMF and DMAC;

[0038] Preferably, the concentration of the polymer solution is 8-12 mg / mL, more preferably 10 mg / mL;

[0039] Preferably, the volume ratio of the polymer solution to the deionized water is 1:(8-16), more pr...

Embodiment 1

[0063] An embodiment of the present invention provides a drug-loaded polymer micelle for treating cardiovascular diseases.

[0064] Synthetic steps of polymer micelles:

[0065] 1.HO(CH 2 ) 11 SeSe(CH 2 ) 11 The preparation steps of OH (bis(11-hydroxyl undecyl) diselenide):

[0066] Sodium borohydride (NaBH 4 ) is dissolved in deionized water, and reacts with selenium powder to generate hydrogen gas and colorless solution sodium diselenide (Na 2 Se 2 ). The mass ratio of sodium borohydride to selenium powder is 2:1; it should be noted that, in other embodiments, the mass ratio of sodium borohydride to selenium powder can be selected within the range of (1.5-2):1.

[0067] Under argon protection, sodium diselenide and 11-bromoundecanol (Br(CH 2 ) 11 OH) in the organic solvent anhydrous tetrahydrofuran (THF) for substitution reaction, the substitution reaction time is 12h, the substitution reaction temperature is 50°C, and then the substitution reaction product is sepa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a drug-loaded polymer micelle for treating cardiovascular diseases and a preparation method and application thereof, and relates to the technical field of cardiovascular therapy. In particular, the polymer micelle is encapsulated with a novel hydrogen sulfide release aspirin, can be applied to a cardiovascular pathological change environment with a low pH and high oxidativestress environment, has a balanced regulation function on vascular physiology, and can be used for long-acting, sustained-release and targeted treatment of the cardiovascular diseases; in particular,the drug-loaded polymer micelles is expected to reduce or avoid the risks of intravascular restenosis, endothelium delayed healing and late thrombosis.

Description

technical field [0001] The present invention relates to the technical field of cardiovascular treatment, in particular to a drug-loaded polymer micelle for treating cardiovascular diseases and its preparation method and application. Background technique [0002] Cardiovascular disease is currently the technology with the highest morbidity and mortality among all diseases, higher than tumors and other diseases, and poses a great threat to human health. Among cardiovascular diseases, coronary heart disease is a very harmful one, and atherosclerosis is the basic cause of coronary heart disease. Percutaneous coronary intervention can restore the normal flow of blood in blood vessels, and it is the main way to treat atherosclerosis clinically, and it has been widely used clinically. [0003] However, when bare metal stents are implanted into patients with atherosclerosis, not only inflammation will occur, but also complications such as intravascular restenosis and late thrombosi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/34A61K31/616A61P9/00A61P9/10
CPCA61K9/1075A61K31/616A61K47/34A61P9/00A61P9/10
Inventor 赵安莎罗丹路槟阳杨苹
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com