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Fingerprint detection method of Kangmao Granules

A technology of anti-mall granules and fingerprints, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as quality control of anti-mall granules, achieve objective and accurate evaluation and control, high precision, and good stability

Active Publication Date: 2021-01-19
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is currently no scientifically effective method for quality control of Kangmao Granules

Method used

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  • Fingerprint detection method of Kangmao Granules
  • Fingerprint detection method of Kangmao Granules
  • Fingerprint detection method of Kangmao Granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]The instruments used in the following examples

[0044]Shimadzu LC-20AB high performance liquid chromatography system from Shimadzu, Japan, including online degassing machine, automatic sampler Prominence SIL-20A, diode array detector SPD-M20A and column thermostat CTO-20A; ME204E electronic analytical balance (Mei Teller-Toledo International Co., Ltd., accurate to one hundred thousandth); BSM220.4 analytical balance (Shanghai Zhuojing company, accurate to one ten thousandth); GVS ultrasonic cleaner (Shenzhen Gowell Technology Co., Ltd. Company); TGL-16C high-speed desktop centrifuge (Shanghai Anting Scientific Instrument Factory).

[0045]The reagents used in the following examples are as follows: chlorogenic acid analysis standard product (batch number 110753-201314, purity 96.6%), baicalin analysis standard product (batch number 110715-201016, purity 94.0%), luteolin analysis standard product (batch number 111720- 201609, purity 94.9%) were purchased from China Institute of Food ...

Embodiment 2

[0064]Example 2 Methodological research of fingerprint detection:

[0065]1. Methodological investigation

[0066]1.1 Precision inspection

[0067]Take a sample of anti-cold particles with the batch number of 180611, prepare the test product solution according to the preparation method of the test product in the above example 1, and inject 6 consecutive samples, each injection volume of 10μL, and test according to the chromatographic conditions of the above example 1. Measure the HPLC chromatogram and examine the five common fingerprint peaks in the chromatogram. The results show that the retention time RSD of the common fingerprint peaks are all less than 2.34%, and the RSD of the common peak area are all less than 1.98%, indicating that the instrument has good precision. .

[0068]1.2 Stability investigation

[0069]Take a sample of anti-cold granules with batch number 180611, prepare the test product solution according to the test product preparation method of the above-mentioned Example 1, and...

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Abstract

The invention discloses a fingerprint detection method for anti-cold granules. The method comprises the steps of: 1, preparing anti-cold granule test solution; 2, preparing mixed reference solution; 3, precisely sucking and injecting the test solution and the reference solution into a liquid chromatograph, respectively, and recording chromatograms; and 4, deriving a fingerprint instrument of the anti-cold granules, importing the fingerprint instrument into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system, selecting chromatographic peaks existing in chromatograms of different batches of anti-cold granules as common peaks, generating a contrast fingerprint of the anti-cold granules by using an average value calculation method, and calculating a relativeretention time and a relative peak area of each common peak. The researched anti-cold granule fingerprint can comprehensively and objectively evaluate the quality of liquorice juice roasted ligustrumlucidum ait. The detection method provided by the invention has the advantages of being good in stability, high in correctness, good in repeatability and high in precision.

Description

Technical field[0001]The invention belongs to the technical field of detection of Chinese patent medicines, and specifically relates to a fingerprint pattern detection method of anti-cold particles and the fingerprint pattern thereof.Background technique[0002]Anti-cold granules is a compound preparation composed of 9 medicinal materials including honeysuckle, forsythia, scutellaria, nepeta, parsnip, isatis root, artemisia annua, platycodon, and licorice. It has the effects of clearing heat and detoxification, and clearing the lung and relieving the surface. It is used for wind-heat and cold. Fever and vicious wind, nasal congestion and headache, sore throat.[0003]According to statistics, the average Chinese adult catches a cold 2-6 times a year, and children 6-8 times. The common cold is divided into two types in academic terms: common cold and influenza. It belongs to upper respiratory tract infection and the cause is viral infection. The common cold has a small impact on people, b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027
Inventor 金俊杰蔡宝昌李国维朱妍格李轩涛
Owner NANJING HAICHANG CHINESE MEDICINE GRPCO LTD