Polyurethane-based spray-type photocurable hydrogel dressing precursor and preparation method

A technology of light curing and precursor liquid, applied in the field of medical materials, can solve the problems of large safety risks of organic solvents, limited use of dressings, limited clinical use, etc., to prolong the curing time, avoid potential safety hazards, and help wound healing.

Active Publication Date: 2020-07-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN107106724A provides a feasible case for the manufacture of application materials with two states, but its material is suitable for use on non-wounded skin surface, has the function of bonding and keeping dry, and cannot be used as a dressing for wounded skin surface, and There is a very large safety risk in organic solvent residues, which leads to limited clinical use

Method used

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  • Polyurethane-based spray-type photocurable hydrogel dressing precursor and preparation method
  • Polyurethane-based spray-type photocurable hydrogel dressing precursor and preparation method
  • Polyurethane-based spray-type photocurable hydrogel dressing precursor and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Add 13.34g of isophorone diisocyanate and 24g of polytetrahydrofuran diol-2000 into a three-neck flask (100mL) equipped with a thermometer, a reflux condenser and a stirrer, add 2-3 drops of stannous octoate dropwise, Under the condition of nitrogen gas mixing and stirring for 3h. Then, the temperature was lowered to 50° C., 2.4 g of 2,2-dimethylolpropionic acid were respectively added into the above reaction system, and the temperature was kept and stirred for 2 h. Afterwards, the temperature was lowered to 57° C. and the stirring was continued for 0.5 to 1 hour to obtain a polyurethane prepolymer. Finally, 2.02 g of triethylamine was added to 97.44 g of deionized water to prepare an emulsified neutralization solution. At room temperature, slowly add the prepared polyurethane prepolymer into the neutralizing solution, and stir at a high speed for about 2 hours with a shear emulsifier to obtain an anionic polyurethane emulsion with a water content of 70 wt%. Emulsion ...

Embodiment 2

[0039] Add 13.34g of isophorone diisocyanate and 24g of polytetrahydrofuran diol-2000 into a three-neck flask (100mL) equipped with a thermometer, a reflux condenser and a stirrer, add 2-3 drops of stannous octoate dropwise, Under the condition of nitrogen gas mixing and stirring for 3h. Then, the temperature was lowered to 60° C., and a certain amount of 2.14 g of methyldiethanolamine was added to the above reaction system, and the temperature was kept and stirred for 2 hours. Afterwards, an appropriate amount of acetone (5-20 mL) was added to adjust the viscosity of the reaction system, the temperature was lowered to 57° C. and stirring was continued for 0.5-1 h to obtain a PU prepolymer. Finally, 2.3 g of acetic acid was added to 97.44 g of deionized water to prepare an emulsified neutralization solution. At room temperature, slowly add the prepared polyurethane prepolymer into the neutralizing solution, and stir at a high speed for about 2 hours with a shear emulsifier to...

Embodiment 3

[0043] Add 13.34g of isophorone diisocyanate and 24g of polytetrahydrofuran diol-2000 into a three-neck flask (100mL) equipped with a thermometer, a reflux condenser and a stirrer, add 2-3 drops of stannous octoate dropwise, Under the condition of nitrogen gas mixing and stirring for 3h. Then, the temperature was lowered to 50° C., 2.4 g of 2,2-dimethylolpropionic acid were respectively added into the above reaction system, and the temperature was kept and stirred for 2 h. Afterwards, the temperature was lowered to 57° C. and the stirring was continued for 0.5 to 1 hour to obtain a polyurethane prepolymer. Finally, 2.02 g of triethylamine was added to 97.44 g of deionized water to prepare an emulsified neutralization solution. At room temperature, slowly add the prepared polyurethane prepolymer into the neutralizing solution, and stir at a high speed for about 2 hours with a shear emulsifier to obtain an anionic polyurethane emulsion with a water content of 70 wt%.

[0044] ...

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Abstract

The present invention discloses a polyurethane-based spray-type photocurable hydrogel dressing precursor liquid. The precursor liquid contains polyurethane, a photocuring polymer monomer, a photoinitiator and water, wherein a mass content of the photoinitiator is 0.5-5%, a mass content of the water is 50-80%, and a mass ratio of the photocurable polymer monomer to the polyurethane is 1.5:1 to 4:1.A complex viscosity of the precursor liquid is 0.2-0.8 mPa.s. The precursor liquid is sprayed in a liquid form, forms a layer of wound-adaptable adhesive hydrogel dressing on skin wound surface by light curing, is moisturizing, breathable, strong in liquid absorption, excellent in mechanical properties, free of damages once being removed and convenient to use, and can significantly promote healing of wound surfaces.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a polyurethane-based spray-type photocurable hydrogel dressing precursor and a preparation method of the precursor. Background technique [0002] The skin is a tissue located on the surface of the body and wrapped around the muscles. It is an important organ to maintain the stability of the internal environment of the body and resist foreign invasion. It has physical, chemical and biological barrier functions. As the outermost barrier of the human body, the skin is often damaged by various external environmental factors. Burns, scratches, and large areas of ulceration caused by trauma all seriously threaten human health. In China, there are as many as 5 to 10 million burn victims every year, and about 5% of them require hospitalization. In addition, according to the latest data released by the World Health Organization, it is estimated that in the future, 265,000 pe...

Claims

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Application Information

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IPC IPC(8): A61K47/50A61L26/00C08G18/66C08G18/48C08G18/34C08G18/32C08G18/08C08F120/56C08F2/48
CPCA61L26/0014A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/404A61L2300/41A61L2300/412A61L2300/414A61L2300/602C08F2/48C08F120/56C08G18/0823C08G18/3275C08G18/348C08G18/4854C08G18/6692C08L75/04C08L33/26
Inventor 张利侯毅
Owner SICHUAN UNIV
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