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Method for preparing temperature-sensitive magnetic porous micro-sphere

A technology of porous microspheres and temperature sensitivity, applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve problems such as low specific surface area, limit stimulus response rate, etc., and achieve reduced volume size , increase the specific surface area and porosity, and the effect of easy operation

Inactive Publication Date: 2019-07-26
武夷学院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polystyrene microspheres prepared by this method are solid microspheres with no porous structure and low specific surface area, which limits their response rate to external stimuli.

Method used

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  • Method for preparing temperature-sensitive magnetic porous micro-sphere
  • Method for preparing temperature-sensitive magnetic porous micro-sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) Preparation of quenching solution

[0030] Add 0.9g of polystyrene into the mixed solution of 5g of tetrahydrofuran, 2g of N,N-dimethylformamide and 2g of ethyl acetate, stir and dissolve at room temperature. Add 0.001g of nano-hydroxyapatite and 0.015g of nano-ferric oxide into the above solution, stir and disperse at room temperature to obtain a quenching solution.

[0031] 2) Quenching

[0032] Pour the quenching solution into a petri dish and put it in a -20°C refrigerator to quench for 6 hours. After quenching, put the petri dish into an ice-water mixture, change the distilled water every 6 hours, change 4 times, and extract and remove the ternary mixed solvent. Finally, freeze-dry to obtain polystyrene magnetic porous microspheres.

[0033] 3) Activation of magnetic porous microspheres

[0034] Soak the polystyrene magnetic porous microspheres in a mixed solution of 5 g of benzophenone and 95 g of ethanol for activation, take them out after 5 min, dry them i...

Embodiment 2

[0039] 1) Preparation of quenching solution

[0040] Add 1.2g of polystyrene into the mixed solution of 6g of tetrahydrofuran, 3g of N,N-dimethylformamide and 3g of ethyl acetate, stir and dissolve at room temperature. Add 0.002g of nano-hydroxyapatite and 0.003g of nano-ferric oxide into the above solution, stir and disperse at normal temperature to obtain a quenching solution.

[0041] 2) Quenching

[0042] Pour the quenching solution into a petri dish and put it in a -30°C refrigerator to quench for 4 hours. After quenching, put the petri dish into an ice-water mixture, change the distilled water every 6 hours, change 4 times, and extract and remove the ternary mixed solvent. Finally, freeze-dry to obtain polystyrene magnetic porous microspheres.

[0043] 3) Activation of magnetic porous microspheres

[0044] Soak the polystyrene magnetic porous microspheres in a mixed solution of 5 g of benzophenone and 95 g of ethanol for activation, take them out after 5 min, dry them...

Embodiment 3

[0049] 1) Preparation of quenching solution

[0050] Add 1.0 g of polystyrene into a mixed solution of 7 g of tetrahydrofuran, 3 g of N,N-dimethylformamide and 2.5 g of ethyl acetate, and stir to dissolve at room temperature. Add 0.015g of nano-hydroxyapatite and 0.002g of nano-ferric oxide into the above solution, stir and disperse at room temperature to obtain a quenching solution.

[0051] 2) Quenching

[0052] Pour the quenching solution into a Petri dish, put it in a refrigerator at -25°C for 5 hours, put the Petri dish into an ice-water mixture after quenching, change the distilled water every 6 hours, change 4 times, extract and remove the ternary mixed solvent. Finally, freeze-dry to obtain polystyrene magnetic porous microspheres.

[0053] 3) Activation of magnetic porous microspheres

[0054] Soak the polystyrene magnetic porous microspheres in a mixed solution of 5 g of benzophenone and 95 g of ethanol for activation, take them out after 5 min, dry them in vacuum...

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Abstract

The invention discloses a method for preparing a temperature-sensitive magnetic porous micro-sphere. The particle size of the temperature-sensitive magnetic porous micro-sphere prepared by the methodis 10-30 micrometers, the specific surface area of the micro-sphere is 95.1%, and the porosity of the micro-sphere is 20.1m<2> / g. The prepared temperature-sensitive magnetic porous micro-sphere can beused for drug carriers, targeted therapy, sustained drug release and the like. The method for preparing the temperature-sensitive magnetic porous micro-sphere includes the steps: 1) preparing a polystyrene magnetic porous micro-sphere; 2) preparing a polystyrene magnetic porous micro-sphere grafted poly (N-isopropylacrylamide). The method is simple, high in yield and quite suitable for industrialproduction.

Description

technical field [0001] The invention relates to a preparation method of temperature-sensitive magnetic porous microspheres, belonging to the technical field of functional polymer porous materials. Background technique [0002] Polymer microspheres refer to spherical polymer particles with a particle size ranging from tens to hundreds of microns. Due to the small size and volume of polymer microspheres, the whole particle has the characteristics of fast response rate and high reaction rate to external stimuli, and the large specific surface area can be used as the position of adsorption, desorption, chemical reaction and light scattering. [0003] As the carrier of active molecules such as enzymes and proteins, polymer microspheres have shown good application prospects in the fields of medical diagnosis, clinical testing, and biosensors. As bioactive molecule immobilization carriers, hydrophilic hydrogel and hydrophobic microspheres are both good carriers of bioactive molecu...

Claims

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Application Information

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IPC IPC(8): C08F257/02C08F220/54C08F222/38C08K3/32C08K3/22B01J20/26B01J20/28B01J20/30
CPCB01J20/048B01J20/06B01J20/261B01J20/28009C08F222/385C08F257/02C08K3/22C08K3/32C08K2003/2275C08K2003/325C08K2201/01C08K2201/011C08F220/54
Inventor 刘瑞来林皓刘淑琼苏丽鳗江慧华
Owner 武夷学院