Synthesizing method for chloroacetamide compound

Abstract

The invention discloses a synthesizing method for a chloroacetamide compound. In a reaction kettle, a secondary amine compound is dissolved in an organic solvent, the mixture is heated for reflux, chloroacetyl chloride is added into the mixture, a reflux reaction is conducted for 0.5-20 hours, and the chloroacetamide compound is obtained. According to the synthesizing method for the chloroacetamide compound, an acid binding agent is not used, discharging of wastewater in the after-treatment process is reduced, by keeping the reflux state of the system, hydrogen chloride gas generated from thereaction is exhausted out of the system and absorbed by water outside the system, high-purity hydrochloric acid is obtained, the waste is turned into wealth, the method comes up to the production standard of safety and environment protection, and discharging of waste gas, waste water and waste residues is reduced; according to the synthesizing method for the chloroacetamide compound, few operationsteps are utilized, the reaction speed is high, the product yield is high, the purity is high, the production cost is low, and the method is safe, friendly to the environment and suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing chloroacetamide compounds. Background technique [0002] Chloroacetamide compounds are a class of important organic compounds, alachlor, acetochlor, pretilachlor, propachlor, butachlor, metazachlor, metacetamine, dimethachlor ( High-efficiency metolachlor), metolachlor and refined metolachlor are all outstanding representatives of this class of compounds, and refined metolachlor is one of the best. The refined metolachlor was developed by Syngenta, and it went on the market in the United States in 1997. On October 16, 2001, the protection period of the US patent expired. Metolachlor, like metolachlor, is a cell division inhibitor, but according to the results of toxicology studies, its toxicity is lower than that of metolachlor, only one-tenth of the toxicity of the latter. Slim metolachlor has a wide crop spectrum and is the main herbicide u...

AI Technical Summary

Problems solved by technology

[0003] The current production process for synthesizing chloroacetamide compounds is complicated, and a large amount of hydrogen chloride gas will be generated during the reaction process. Generally, the reaction system needs to be kept in a negative pressure state, and the requirements for reaction conditions and production equipment are strict. In the current synthesis method, generally An acid-binding agent will be added, but this method will produce more salt and a small amount of alkali-containing wastewater. In order to remove the salt generated by the acid-binding agent during the post-treatment process after the reaction, a large amount of water is required for washing. This operation will also A large amount of salty wastewater is produced, the post-treatment process is difficult, and it does not meet the current national green environmental protection requirements

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