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Pharmaceutical composition against Pasteurella multocida
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A Pasteurella, multi-kill technology, used in antibacterial drugs, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as drug resistance, and achieve the effects of reducing toxic side effects, high bactericidal activity, and good antibacterial effects
Inactive Publication Date: 2021-09-24
JILIN UNIV
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[0004] At present, the treatment of bovine pasteurellosis mainly relies on antibiotics, but with the long-term use of antibiotics, the problem of drug resistance inevitably appears
Method used
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Embodiment 1
[0020] Embodiment 1: the combined antibacterial test of pharmaceutical composition to Pasteurella multocida
[0021] 1. Experimental materials and methods
[0022] Reagents and reagents:
[0023] Ciprofloxacin (Ciprofloxacin), Thioridazine (Thioridazine) and Tetracycline (Tetracyclines) were purchased from MCE Company, with purity >98.74%, >99.93%, and >98%, respectively.
[0024] Indicator strain:
[0025] Escherichia coli: Escherichia coli, 25922 (E. coli 25922); standard strain 450, clinically isolated Pa strains: Pa 01, Pa 02, Pa 03, Pa 04, Pa 05, Pa 06, Pa 07, Pa 08, Pa09, Pa 010.
[0026] Medium:
[0027] BHI medium: 10.0g peptone, 12.5g dehydrated calf brain extract powder, 5g dehydrated beef heart extract powder, 5g sodiumchloride, 2g glucose, 2.5g disodium hydrogen phosphate in 1000mL distilled water, and adjust the pH to 7.4. The prepared culture medium was autoclaved at 121°C, and after 20 minutes, it was ready for use.
[0028] MH medium: mix 2.0 g of b...
Embodiment 2
[0050] Embodiment 2: The effect of the drug composition administration treatment on the Pneumonia model of Pasteurella multocida bovine
[0051] 1. Experimental materials and methods
[0052] Reagents and reagents:
[0053] Ciprofloxacin (Ciprofloxacin), Thioridazine (Thioridazine) and Tetracycline (Tetracyclines) were purchased from MCE Company, with purity >98.74%, >99.93%, and >98%, respectively.
[0054] Strains:
[0055] Standard Pa strain 450, clinical isolate Pa strain Pa 1.
[0056] Medium:
[0057] BHI medium: 10.0g peptone, 12.5g dehydrated calf brain extract powder, 5g dehydrated beef heart extract powder, 5g sodiumchloride, 2g glucose, 2.5g disodium hydrogen phosphate in 1000mL distilled water, and adjust the pH to 7.4. The prepared culture medium was autoclaved at 121°C, and after 20 minutes, it was ready for use.
[0058] animal
[0059] SPF-grade BALB / C mice, male, weighing 18-22g, were purchased from Changchun Yisi Experimental Animal Co., Ltd. The lab...
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Abstract
The invention relates to a pharmaceutical composition for resisting Pasteurella multocida bovis, which belongs to the technical field of pharmaceutical compositions. The object of the present invention is to effectively synthesize three kinds of medicines into combined medicines, and to be an antibacterial medicine composition for treating Pasteurella multocida infection in bovines. The active ingredients prepared by the present invention are ciprofloxacin, thioridazine and tetracycline. The pharmaceutical composition of the present invention has clinical effects such as antibacterial and anti-inflammatory, and can effectively treat Pasteurella multocida infection. In addition, the pharmaceutical composition of the present invention has high-efficiency bactericidal activity and can greatly reduce the dosage of medication, thereby greatly Reduce the toxic and side effects of drugs. The basic mechanism of the combined action of the drug is: through joint inhibition of the export pump of bacteria, as well as the synthesis and replication of DNA, so that it has a good antibacterial effect. Further prove the clinical efficacy and safety of the medicine of the present invention.
Description
technical field [0001] The invention belongs to the technical field of pharmaceutical compositions. Background technique [0002] Pasteurella is a sporeless, non-motile, facultative anaerobic, Gram-negative small bacillus that often stains heavily at both ends of the bacteria. The identified species of this genus are Pasteurella multocida, Pasteurella pneumophila, Pasteurella hemolyticus, Pasteurella urinae and Pasteurella anatipestifer. Pasteurella multocida is a two-segment blunt round, central micro-protruding brevibacterium or coccus, non-spore-forming, non-motile, flagella-free, Gram-negative aerobic facultativeanaerobic bacteria. [0003] Pasteurellosis is a zoonotic infectious disease mainly caused by pathogenic bacteria such as Pasteurella multocida. Pasteurella can be transmitted among various animals, and animal bites can also directly cause pathogenic bacteria to enter the epithelial cells of the human body, causing local tissue damage and even systemic disease...
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