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Pharmaceutical composition for treating Alzheimer's disease

A technology for Alzheimer's disease and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve good social and economic benefits

Inactive Publication Date: 2019-08-23
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After investigation, there is currently no pharmaceutical composition for the combined use of industrial hemp flower leaf extracts, artemisinin and its derivatives for the treatment of Alzheimer's disease

Method used

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  • Pharmaceutical composition for treating Alzheimer's disease
  • Pharmaceutical composition for treating Alzheimer's disease
  • Pharmaceutical composition for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] This example provides an injection of a pharmaceutical composition for the treatment of Alzheimer's disease. The operation is as follows: Weigh 2000 mg of industrial hemp flower leaf extract with a cannabidiol content higher than 99%, 1000 mg of artemether, and add oil for injection 200mL; the medicinal solution is aseptically filtered through a 0.22μm microporous membrane, filled, and capped.

Embodiment 2

[0020] This example provides a tablet of a pharmaceutical composition for the treatment of Alzheimer's disease. The operation is as follows: Weigh 100 g of industrial hemp flower leaf extract with a cannabidiol content of about 60%, 30 g of artesunate, 355 g of starch, Magnesium stearate 15g, mixing, granulating, drying, tabletting, every heavy 0.5g, obtains tablet dosage form of the present invention.

Embodiment 3

[0022] This embodiment provides a drop pill of a pharmaceutical composition for the treatment of Alzheimer's disease. The operation is as follows: Weigh 50 g of industrial hemp flower leaf extract, 10 g of artemisinin, and take polyethylene glycol 4000 and polyethylene glycol 6000 appropriate amount, heat and melt in a water bath at 80-85°C, add the above two raw materials weighed, mix well, keep the temperature at 75°C, drop into liquid paraffin (0-5°C), and make 1000 grains, namely Get the drop pill dosage form of the present invention.

[0023] The pharmaceutical composition for treating Alzheimer's disease provided by the invention fully utilizes the advantages of the two active ingredients, helps to promote the further development of the industrial hemp industry, and has good social and economic benefits.

[0024] Pharmacodynamic study

[0025] Effects of drug treatment on AD model mice established by subcutaneous injection of D-galactose and gavage of aluminum chloride....

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Abstract

The invention discloses a pharmaceutical composition for treating the Alzheimer's disease. The pharmaceutical composition is characterized in that the composition is a preparation prepared from an effective dosage of industrial cannabis leaves, artemisinin, a series of derivatives and pharmaceutically acceptable auxiliary materials thereof. The composition can effectively relieve the Alzheimer's disease. The pharmaceutical composition is large in safety dosage range and good in curative effect and has the good development prospect. By applying the medicine technology, the novel development direction is supplied to medicine application of industrial cannabis, and the good social and economical benefits are achieved.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a pharmaceutical composition for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease, also known as senile dementia, is a degenerative disease of the central nervous system with an insidious onset and a chronic progressive course. It is the most common type of senile dementia. The main manifestations are neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language barriers, which seriously affect social, occupational, and life functions. The etiology and pathogenesis of AD have not yet been elucidated, and the characteristic pathological changes are extracellular senile plaques formed by the deposition of β-amyloid protein, neurofibrillary tangles formed by hyperphosphorylation of tau protein, and neuron loss with glial cell proliferation Wait. [0003] Since the etiology and pathogenesis of AD are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P25/28A61K31/366
CPCA61K31/366A61K36/66A61P25/28A61K2300/00
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏
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