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Artificial lens containing antibiotics and preparation method thereof

An intraocular lens and antibiotic technology, applied in the direction of prosthesis, tissue regeneration, medical science, etc., can solve the problem that the strength and transparency of intraocular lens cannot be taken into account, and achieve short production process time, good biocompatibility, and light transmission. high rate effect

Active Publication Date: 2019-08-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a high-strength, high-transmittance light-cured intraocular lens containing antibiotics and its production in view of the problems that drugs cannot be directly mixed into the lens raw materials in the prior art, and the strength and transparency of the intraocular lens cannot be taken into account. method

Method used

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  • Artificial lens containing antibiotics and preparation method thereof
  • Artificial lens containing antibiotics and preparation method thereof
  • Artificial lens containing antibiotics and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: In this example, a foldable intraocular lens containing gatifloxacin was prepared.

[0034] The preparation method comprises the following steps:

[0035] (1) Prepare a polyurethane acrylate prepolymer: the molar ratio of isocyanate: polyether polyol: hydroxy acrylate is 2:1:2.1. The reaction vessel is a 250ml four-necked flask, which is connected with an overhead mechanical stirrer, a reflux condenser, a constant pressure dropping funnel, a thermometer, and nitrogen gas. The heating device is an oil bath. 4.4456 g of isophorone diisocyanate and 0.0086 g of a catalyst dibutyltin dilaurate were put into a four-necked flask, and 10.0000 g of polyethylene glycol-1000 was added dropwise at 60°C. After reacting for 2 hours, slowly add 2.4385g of 2-hydroxypropyl acrylate and 0.0273g of hydroquinone, raise the temperature to 80°C and continue the reaction for 3 hours to obtain a transparent viscous liquid, which should be sealed and stored in a cool place.

[0036...

Embodiment 2

[0041] Example 2: In this example, a foldable intraocular lens containing levofloxacin was prepared.

[0042] The preparation method comprises the following steps:

[0043] (1) Prepare a polyurethane acrylate prepolymer: the molar ratio of toluene diisocyanate: polytetrahydrofuran-1000: 2-hydroxyethyl acrylate is 5:1:8.1. The reaction vessel is a 250ml four-necked flask, which is connected with an overhead mechanical stirrer, a reflux condenser, a constant pressure dropping funnel, a thermometer, and nitrogen gas. The heating device is an oil bath. Put 9.4057g of 2-hydroxyethyl acrylate and 0.0930g of hydroquinone into a four-neck flask, add 8.7100g of toluene diisocyanate dropwise at 30°C, and react for 5 hours, then slowly add 10.0000g of polytetrahydrofuran-1000, and raise the temperature The reaction was continued at 40°C for 6 hours to obtain a transparent viscous liquid, which was sealed and stored in a cool place.

[0044] (2) Preparation of photocurable resin compone...

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Abstract

The invention provides an artificial lens containing antibiotics. The antibiotics and a reactive diluent are fully mixed, then, after being mixed with polyurethane-acrylate prepolymers, a photoinitiator and an ultraviolet absorber, the mixture is poured into a light-permeable mold in an artificial lens shape, and through photocuring polymerization of fixed wavelength and demolding purification, the soft and foldable artificial lens can be produced. The artificial lens has excellent optical and mechanical properties, the target antibiotics contained in the artificial lens are not denaturalizedand can be released for a long time, the artificial lens is formed rapidly, no later polish treatment is needed, the antibacterial capability of the antibiotics is high, the biocompatibility is good,and thus the artificial lens is suitable for serving as a specific medical artificial lens.

Description

technical field [0001] The invention belongs to the field of preparation of medical intraocular lenses, in particular to a method for quickly producing antibiotic-containing intraocular lenses using polyurethane-acrylic ester materials as the main body. Background technique [0002] Currently, soft intraocular lenses for human eyes mainly use materials such as silicone gel, hydrophilic polyacrylate and hydrophobic polyacrylate, especially polyacrylate intraocular lenses have become the mainstream of clinical choice. Most polyacrylate IOLs still use thermal polymerization in the industry. Under the action of a thermal initiator, the material usually needs to be cured at high temperature for more than 24 hours. The polymerization reaction takes a long time and consumes a lot of energy; It is a material sheet, after the material is detoxified, it still needs to be machine-cut, polished, polished, etc. in the later stage, and the production cycle is long; and the polyacrylate in...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/54A61L27/50
CPCA61L27/16A61L27/50A61L27/54A61L2300/406A61L2430/16C08L33/08
Inventor 姚克李梦娜徐经纬徐志康
Owner ZHEJIANG UNIV
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