Bionic micro-nano laminated hydrophobic biological valve and preparation method thereof

A biological valve, micro-nano lamination technology, applied in the direction of coating, tissue regeneration, drug delivery, etc., can solve the problems of prone to thrombus and calcification, reduce the formation of thrombus and calcification spots, good blood compatibility, The effect of extending the service life

Active Publication Date: 2019-08-23
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at problems such as thrombus and calcification in the cross-linked biological valve, the present

Method used

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  • Bionic micro-nano laminated hydrophobic biological valve and preparation method thereof
  • Bionic micro-nano laminated hydrophobic biological valve and preparation method thereof
  • Bionic micro-nano laminated hydrophobic biological valve and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] (1) Selection and modified pretreatment of biological valves and inorganic nanoparticles

[0039] Cross-linking treatment of biological valves: Freshly collected porcine pericardium was repeatedly washed with deionized water at 4°C and 100 rpm for 2 hours, then soaked in 0.6wt% glutaraldehyde for 24 hours; rinsed with deionized water at least 5 times, and then used;

[0040] Pretreatment of biological valves: Soak the porcine pericardium after cross-linking and fixing with ethanol for 90 minutes, then soak and rinse with deionized water for at least 3 times, and dry at 80°C for 4 hours; then use 1.0wt% 3-glycidol Soak in etheroxypropyl trimethoxysilane for more than 30 minutes, and place it at 80°C for 1 hour to obtain a pretreated biological valve;

[0041] Pretreatment of silica: Soak 50nm silica in ethanol for 90min, soak and rinse with deionized water for at least 3 times, and dry at 80°C for 4h; then use 1.0wt% 3-glycidyl ether oxygen Soak in propyltrimethoxysilan...

Embodiment 2

[0050] (1) Selection and modified pretreatment of biological valves and inorganic nanoparticles

[0051] Cross-linking treatment of biological valves: Freshly collected bovine pericardium was repeatedly washed with deionized water at 4°C and 100 rpm for 2 hours; then soaked in 0.6wt% glutaraldehyde for 24 hours; rinsed with deionized water for at least 5 times, and set aside;

[0052] Pretreatment of biological valves: Soak the bovine pericardium after cross-linking and fixation with ethanol for 60 minutes, then soak and rinse with deionized water for at least 3 times, and dry at 70°C for 6 hours; then use 1.5wt% bis(dioctyl Soak in oxypyrophosphate) ethylene titanate for 45 minutes, and react at 70°C for 1.5 hours;

[0053] Pretreatment of silicon dioxide: soak 100nm silicon dioxide in ethanol for 90 minutes, soak and rinse with deionized water for at least 3 times, and dry at 80°C for 4 hours; then use 2wt% bis(dioctyloxycoke Phosphate-based) ethylene titanate soaked for 45...

Embodiment 3

[0068] (1) Selection and modified pretreatment of biological valves and inorganic nanoparticles

[0069] Cross-linking treatment of biological valves: Freshly collected bovine pericardium was repeatedly washed with deionized water at 4°C and 100 rpm for 2 hours; then soaked in 4.0wt% paraformaldehyde for 4 hours; rinsed with deionized water for at least 5 times, and set aside;

[0070]Pretreatment of biological valve: Soak the cross-linked and fixed bovine pericardium with ethanol for 120 minutes, then soak and rinse with deionized water for at least 3 times, and dry at 60°C for 24 hours; then use 3.0wt% 3-aminopropanol Soak in triethoxysilane for 60 minutes, and react at 60°C for 3 hours;

[0071] Pretreatment of titanium dioxide: first soak 50nm titanium dioxide in ethanol for 120min, then soak and rinse with deionized water for at least 3 times, and dry at 60°C for 24h; then use 2.5wt% 3-aminopropyltriethoxysilane Soak for more than 30min, and place it at 60°C for 3h.

[...

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Abstract

The invention discloses a bionic micro-nano laminated hydrophobic biological valve and a preparation method thereof. The hydrophobic biological valve is formed by constructing a bionic micro-nano laminated compound network structure on the pericardium surface after cross-linking fixation through a layer-by-layer superposition mode, so that the contact angle of the surface of the valve is 90-145 degrees. The number of bionic micro-nano laminated compound laminations on the surface of the valve is 1-5, wherein a hydrophobic network topology basic framework is constructed on the surface and innerportion of the valve in the first layer; a stable network topology structure required by hydrophobicity is formed in the second layer, the third layer, the fourth layer and the fifth layer. The hydrophobic biological valve has obvious anticoagulation and anti-adhesion properties, and can effectively reduce the formation of thrombi and calcified spots; since the multilayer structure of the hydrophobic biological valve is hydrophobic high-molecular polymer mixed cross-linking membrane layers from inside to outside, the formed hydrophobic structure has long-term stability under the blood environment in the body.

Description

technical field [0001] The invention belongs to the technical field of biological valves, and in particular relates to a bionic micro-nano laminated hydrophobic biological valve and a preparation method thereof. Background technique [0002] With the acceleration of population aging, heart valve disease has become a huge global medical burden. The prevalence of heart valve disease in people over the age of 75 in western countries is as high as 13.3%. In China, there are more than 4 million patients with valve disease over the age of 60. people. Such diseases can be treated by drugs or surgery. If the pathological damage of the patient's heart valve reaches a certain level, it is necessary to replace its structure and function with an artificial heart valve. [0003] At present, artificial heart valves used for valve replacement can be divided into biological valves (Bioprosthetic Valve) and mechanical valves (Mechanical Valve). Compared with mechanical valves, biological v...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/30A61L27/36A61L27/50A61L27/54
CPCA61L27/306A61L27/34A61L27/3625A61L27/3641A61L27/3687A61L27/50A61L27/54A61L2300/42A61L2400/18A61L2420/02A61L2420/04A61L2420/08A61L2430/20A61L2430/40C08L83/04C08L83/08
Inventor 兰小蓉王云兵雷洋何周坤
Owner JILIN VENUS HAOYUE MEDICAL LTD
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