Comprehensive disposal method of metronidazole wastewater

A comprehensive treatment and metronidazole technology, applied in the field of high-salt and high-COD chemical wastewater treatment, can solve the problems that restrict the healthy development of metronidazole raw materials, high concentration of organic pollutants, high salinity of metronidazole wastewater, and achieve recovery costs Low cost, high recovery efficiency, and cost-saving treatment effects

Active Publication Date: 2019-08-27
GRAND PHARM (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Metronidazole wastewater has the characteristics of high salinity, high concentration of organic pollutants, complex components, poor biodegradability, etc., and its treatment is difficult
At present, the status quo of metronidazole wastewater treatment technology has restricted the healthy development of my country's metronidazole API industry

Method used

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  • Comprehensive disposal method of metronidazole wastewater

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The present embodiment provides a kind of comprehensive treatment method of metronidazole waste water, such as figure 1 As shown, the details are as follows:

[0050] Add the waste water stock solution into a container (such as a flask), stir, and concentrate under reduced pressure (90°C, -0.09MPa) until the raffinate volume is 52% of the waste stock solution, collect fractions, and cool the raffinate (primary raffinate) to Centrifuge at 35°C to obtain a white granular solid. Continue to concentrate the filtrate under reduced pressure (90°C, -0.09MPa) to a water content of 5%. Water and ethanol were stirred for 60 minutes, cooled to 25°C, filtered to obtain a yellowish granular solid, the filtrate was distilled at atmospheric pressure, and ethanol was recovered. When the concentrated solution was heated to 110°C, no fractions flowed out, and the distillation was completed to obtain a dark red raffinate ( Three times of raffinate), adding water of 1 times the quality of...

Embodiment 2

[0053] Add the waste water stock solution into the flask, stir, and concentrate under reduced pressure (90°C, -0.09MPa) until the residual liquid volume is 46.8% of the original water liquid, collect fractions, cool the residual liquid (primary residual liquid) to 35°C, and centrifugally filter. Obtain a white granular solid, continue to concentrate the filtrate under reduced pressure (90°C, -0.09MPa) to a water content of 8%, and obtain a secondary raffinate, add anhydrous methanol twice the mass of the secondary raffinate while hot, and stir for 60 minutes , cooled to 25°C, filtered to obtain a yellowish granular solid, the filtrate was distilled at atmospheric pressure, methanol was recovered, no fractions flowed out when the concentrated solution was heated to 90°C, and the distillation was completed to obtain a dark red raffinate (three raffinate), which was sent to Add three times the amount of residual liquid to 1 times the mass of water for dilution.

[0054] Take the ...

Embodiment 3

[0056] Add the waste water stock solution into the flask, stir, and concentrate under vacuum distillation (90°C, -0.09MPa) until the volume of the residual liquid is 56% of the original water liquid, collect fractions, cool the residual liquid (primary residual liquid) to 35°C, and centrifugally filter. A white granular solid was obtained, and the filtrate continued to be concentrated under reduced pressure (90°C, -0.09MPa) until the water content was 11%, and the secondary raffinate was obtained, and anhydrous methanol with 1.5 times the mass of the secondary raffinate was added while it was hot, and stirred for 60 minutes , cooled to 25°C, and centrifuged to obtain a yellowish granular solid. The filtrate was distilled at atmospheric pressure, and methanol was recovered. When the concentrated solution was heated to 90°C, no fractions flowed out, and the distillation was completed to obtain a dark red raffinate (three raffinate), Add water of 1 times the mass of the three resi...

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Abstract

The invention discloses a disposal method of metronidazole wastewater and relates to the technical field of wastewater disposal. The provided disposal method is adopted for comprehensively disposing high-concentration metronidazole wastewater in combination with a concentration technology, an organic extraction technology, a Fenton oxidation technology and a biochemical disposal technology, wherein the process comprises the following eight main disposal steps of double-effect concentration of a mother liquor collected after metronidazole is subjected to hydroxylation three times, precipitation, single-effect concentration, alcohol precipitation, alcohol recovery, physicochemical disposal, anaerobic biochemical disposal and aerobic biochemical disposal. Compared with existing metronidazolewastewater disposal technologies, the method has a better way to solving the problems of complex components, ultrahigh salinity and high COD in the metronidazole wastewater. Meanwhile, nitrates, sodium sulfate and sodium formate can also be recycled, and the method has great environmental and economic benefits.

Description

technical field [0001] The invention relates to the field of high-salt and high-COD chemical wastewater treatment, in particular to a method for treating metronidazole wastewater. Background technique [0002] Metronidazole is a nitroimidazole synthetic antibacterial drug with broad-spectrum anti-anaerobic and anti-protozoal effects. As a bulk drug, the annual demand in the global market is huge. At present, the main synthesis process of metronidazole is the hydroxyethylation reaction of 2‐methyl‐5‐nitroimidazole (nitride) and excess ethylene oxide in a mixed solvent of formic acid and sulfuric acid to synthesize metronidazole, and undergo acid and alkali Neutralize and extract unreacted raw material nitrates and metronidazole. This process determines that metronidazole wastewater contains high concentrations of sodium formate, sodium sulfate, ethylene glycol (polymers containing ethylene glycol) and some nitro Imidazole compounds, including sodium formate and sodium sulfat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F9/14C02F103/36
CPCC02F9/00C02F2103/36C02F1/001C02F1/04C02F1/46104C02F1/722C02F1/725C02F1/66C02F1/56C02F1/5236C02F3/301C02F1/048
Inventor 赵涛涛张伟饶坤仑汪振飞皮金红张琦谢国范吴鸣
Owner GRAND PHARM (CHINA) CO LTD
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