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Medicine for treating postpartum depression and preparation method of preparation thereof

A technology for treating postpartum depression and drug, applied in the field of medicine, can solve the problems of inability to achieve patient effect, toxic and side effects, and achieve the effects of low cost, obvious treatment effect and simple production process

Inactive Publication Date: 2019-08-30
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs for clinical treatment of depression at home and abroad, especially for the treatment of postpartum depression, are chemical drugs, such as tricyclic and tetracyclic antidepressants. These drugs have many contraindications and cannot achieve satisfactory results for patients. Long-term use of these drugs can produce toxic side effects

Method used

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  • Medicine for treating postpartum depression and preparation method of preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The prescription is:

[0032] Angelica 30%

[0033] Motherwort 68%

[0034] Sucrose 2%

[0035] Preparation method: take angelica and motherwort according to the prescription amount, and wash them with water respectively. Angelica was cut into thin slices, Motherwort was cut into small pieces, baked and dried at 105°C. After drying, the angelica and motherwort are mixed, crushed into 20-mesh powder, stevioside is added, mixed evenly, and packed into teabags with a weight of 5 grams per bag.

Embodiment 2

[0037] The prescription is:

[0038] Angelica 20%

[0039] Motherwort 79.5%

[0040] Stevia 0.5%

[0041] Preparation method: take angelica and motherwort according to the prescription amount, and wash them with water respectively. Angelica sinensis was cut into thin slices, soaked in 5 times the amount of 60% ethanol aqueous solution for 1 hour, then refluxed and extracted 3 times for 2 hours each time, combined the extracts, and concentrated to extract. Wash the motherwort, cut into small pieces, add 5 times deionized water and decoct 3 times, each decoction for 1 hour, combine the decoction liquid, and concentrate to the extract. Merge the extracts of angelica and motherwort, and dry at 105°C. After drying, crush it into 20 mesh powder, add stevioside, mix evenly, and pack into teabags with a weight of 2 grams per bag.

Embodiment 3

[0043] The prescription is:

[0044]

[0045] Preparation method: take angelica and motherwort according to the prescription amount, and wash them with water respectively. Angelica sinensis was cut into thin slices, soaked in 6 times the amount of 65% ethanol aqueous solution for 1 hour, then refluxed and extracted twice for 2 hours each time, the extracts were combined and concentrated to extract. Wash the motherwort, cut into small pieces, add 6 times deionized water and decoct 3 times, each time for 2 hours, combine the decoction liquid, concentrate to the extract, add stevioside and cyclodextrin, mix and stir, filter, pour pack, cap, and sterilize to obtain the anti-postpartum depression oral liquid.

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Abstract

The invention relates to a medicine for treating postpartum depression and a preparation method of a preparation thereof, and belongs to the technical field of medicines. A formulation of the medicinedisclosed by the invention is prepared from Chinese angelica, herba leonuri and a corrigent. The preparation prepared can be used for treating depression, especially postpartum depression. Natural drug extraction and purification methods are adopted to prepare the preparation with pharmacological effects such as regulating mood, soothing liver and regulating qi, supplementing blood and promotingblood circulation. Active ingredients in the designed formulation and the preparation such as quercetin, caffeic acid, ferulic acid, safrol, cuparen, isoeugenol, 7-Hydroxy-3-butylidenephthalide, 3-Butylidene phthalide, senkyunolide C, genkwanin, wogonin, soybean aglycone, stachydrine and kaempferol synergistically act on key targets PTGS2, GABRA1 / 2 / 3, MAOB, SLC6A4, MAOA, AR, NOS2 / 3, AKT1, CASP3 and ESR1 for emotion regulation to mental disorders, autism and anxiety disorder, thus playing a role of treating depression, especially postpartum depression.

Description

technical field [0001] The invention relates to a medicine for treating postpartum depression and a preparation method thereof, which belongs to the technical field of medicine and is effective for all depressions. Background technique [0002] Postpartum depression is a common mental disorder and affective disease among pregnant women. The clinical manifestations of postpartum depression are depression from the beginning of childbirth to the postpartum period. The main symptoms are fatigue, depression, anxiety, mild emotional disturbance or accompanying There is anxiety and so on. Its characteristic is that the mother is in an unhappy state, manifested as symptoms such as reticence, loss of appetite, insomnia, anxiety, tension, emotional instability, irritability, and inability to concentrate. Postpartum depression not only adversely affects the behavioral development, emotional and even intellectual development of infants and young children, but also greatly affects the p...

Claims

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Application Information

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IPC IPC(8): A61K36/533A61P15/00A61P25/24
CPCA61K36/232A61K36/533A61K2236/331A61K2236/333A61K2236/39A61P15/00A61P25/24A61K2300/00
Inventor 吴学文周恒君熊艳戴勇琦焦甜甜李维王晶陈学飞
Owner XIANGTAN UNIV
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