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Novel copper sulfide based high-efficiency anti-tumor composite material and preparation method and application thereof

A composite material, copper sulfide technology, applied in the nano field, can solve the problems of unsatisfactory tumor effect and low hydrogen peroxide content, and achieve the effect of low cost, simple steps and efficient tumor treatment

Inactive Publication Date: 2019-08-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as far as we know, the process of photodynamic therapy to generate reactive oxygen species depends on the hydrogen peroxide (H 2 o 2 ) content, however, the hydrogen peroxide content of cells in the body is significantly low, so the photodynamic therapy of copper sulfide nanoparticles is not effective in treating tumors as expected

Method used

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  • Novel copper sulfide based high-efficiency anti-tumor composite material and preparation method and application thereof
  • Novel copper sulfide based high-efficiency anti-tumor composite material and preparation method and application thereof
  • Novel copper sulfide based high-efficiency anti-tumor composite material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation method of a novel copper sulfide-based high-efficiency anti-tumor composite material provided in Example 1 comprises the following steps:

[0051] (1) preparation concentration is the copper sulfate solution of 0.4mg / mL, mass fraction is 1% ammoniacal liquor, ammoniacal liquor is added dropwise in the copper sulfate solution of 30mL, the solute copper sulfate of described copper sulfate solution and the solute ammonia gas of ammoniacal liquor The mol ratio is 1:1, stirs and makes cuproammonia complex solution;

[0052] (2) The preparation concentration is 1mg / mL sodium alginate solution, then mixed with the copper ammonium complex solution, stirred and mixed at a speed of 200rpm at room temperature for 0.5h, the volume ratio of the copper ammonia complex solution to the sodium alginate solution is 1:1, to obtain a composite solution;

[0053] (3) Add the sodium sulfide solution with a mass concentration of 2mg / mL dropwise to the above composite solution...

Embodiment 2

[0056] The preparation method of a novel copper sulfide-based high-efficiency anti-tumor composite material provided in Example 2 comprises the following steps:

[0057] (1) preparation concentration is the copper sulfate solution of 1mg / mL, mass fraction is 2.5% ammoniacal liquor, ammoniacal liquor is added dropwise in the copper sulfate solution of 30mL, the solute copper sulfate of described copper sulfate solution and the solute ammonia of ammoniacal liquor are The ratio is 1:2, and the copper ammonia complex solution is obtained by stirring evenly;

[0058] (2) Prepare a sodium alginate solution with a concentration of 4 mg / mL, then mix it with the cuproammonia complex solution, stir and mix for 3 hours at a speed of 400 rpm at room temperature, and the volume ratio of the cuproammonia complex solution to the sodium alginate solution is 1 : 1, obtain composite solution;

[0059] (3) Add the sodium sulfide solution with a mass concentration of 5 mg / mL dropwise to the abov...

Embodiment 3

[0062] The preparation method of a novel copper sulfide-based high-efficiency anti-tumor composite material provided in Example 3 comprises the following steps:

[0063] (1) preparation concentration is the copper sulfate solution of 2mg / mL, mass fraction is the ammoniacal liquor of 5%, ammoniacal liquor is added dropwise in the copper sulfate solution of 30mL, the solute copper sulfate of described copper sulfate solution and the solute ammonia of ammoniacal liquor The molar ratio is 1:5, and the copper ammonia complex solution is obtained by stirring evenly;

[0064] (2) Prepare a sodium alginate solution with a concentration of 5 mg / mL, then mix it with the copper ammonia complex solution, stir and mix for 3 hours at a speed of 400 rpm at room temperature, and the volume ratio of the copper ammonia complex solution to the sodium alginate solution is 1 : 1.5, obtain composite solution;

[0065] (3) Add the sodium sulfide solution with a mass concentration of 7 mg / mL dropwis...

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Abstract

The invention discloses a novel copper sulfide based high-efficiency anti-tumor composite material and a preparation method and application thereof. The method comprises the following steps of preparing copper sulfide nanoparticles in a sodium alginate aqueous solution, co-loading the copper sulfide nanoparticles and glucose oxidase to mesoporous organic silicon, and performing quick synthesis toobtain the novel copper sulfide based high-efficiency antitumor composite material. The composite material has the advantages of being convenient to prepare, convenient to use, notable in anti-tumor effects and the like. Compared with the prior art, the composite material utilizes the thermal effects and photodynamic effects of the copper sulfide nanoparticles in a united manner; the glucose oxidase is added, the photodynamic effects of the copper sulfide nanoparticles can be notably reinforced, and high-efficiency tumor treatment based on nanometer copper sulfide can be realized. The composite material has important application value in the field of photoinduction high-efficiency tumor treatment.

Description

technical field [0001] The invention belongs to the field of nanotechnology, and in particular relates to a novel copper sulfide-based high-efficiency anti-tumor composite material and its preparation method and application. Background technique [0002] Cancer is the leading cause of death worldwide, killing millions every year. Current phototherapy-based cancer treatments have attracted widespread attention due to their convenience and minimal invasiveness. Photothermal therapy and photodynamic therapy are two main methods of phototherapy, both of which use near-infrared lasers to excite photosensitizers to efficiently convert light energy into heat energy or generate highly toxic reactive oxygen species (usually hydroxyl radicals ( OH) , singlet oxygen ( 1 o 2 )), both methods can kill tumor cells. Therefore, photothermal and photodynamic synergistic anti-tumor has an objective prospect. [0003] Currently, many inorganic nanomaterials have been used for photothermal...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61P35/00
Inventor 王小英黄修杰罗碧崇孙润仓
Owner SOUTH CHINA UNIV OF TECH
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