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A fluorescent molecularly imprinted polymer hollow microsphere and its preparation method and application

A technology of fluorescent molecular imprinting and hollow microspheres, which is applied in the fields of fluorescence/phosphorescence, alkali metal compounds, chemical instruments and methods, etc., can solve the problems of inability to detect fast and efficient specificity, unsafe synthesis process, and environmental protection, and achieve significant Quenching effect, effect of fast and efficient synthesis process

Active Publication Date: 2021-08-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a fluorescent molecularly imprinted polymer hollow microsphere and its preparation method and application to solve the existing problems that the target analyte cannot be detected quickly and efficiently, and the synthesis process is not safe and environmentally friendly.

Method used

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  • A fluorescent molecularly imprinted polymer hollow microsphere and its preparation method and application
  • A fluorescent molecularly imprinted polymer hollow microsphere and its preparation method and application
  • A fluorescent molecularly imprinted polymer hollow microsphere and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0049] Include the following steps:

[0050] Step 1: Preparation of silica nanoparticles SiO 2

[0051] First, configure ethanol-deionized water mixed solution, add ammonia water to it, and obtain mixed solution A after ultrasonic treatment for 10 minutes; place mixed solution A at room temperature under magnetic stirring, and slowly add ethyl orthosilicate through a burette under the protection of an inert gas Ester TEOS was reacted until the solution changed from clear and transparent to milky white (obvious change occurred within about 20 minutes), continued to react for 6 hours, collected by centrifugation, washed repeatedly with ethanol-water solution and vacuum freeze-dried for 8 hours to obtain silica Nanoparticles; ammonia water: ethanol: water: tetraethyl orthosilicate 2:25:25:2, magnetic stirring 600rpm, centrifugal speed 10000rpm / min, time 10min,

[0052] Step 2: Preparation of silica surface grafted with fluorescein isothiocyanate SiO 2 Polymers by @FITC-APTES; ...

Embodiment 2

[0060] Include the following steps:

[0061] Step 1: Preparation of silica nanoparticles SiO 2

[0062] First, configure ethanol-deionized water mixed solution, add ammonia water to it, and obtain mixed solution A after ultrasonic treatment for 10 minutes; place mixed solution A at room temperature under magnetic stirring, and slowly add ethyl orthosilicate through a burette under the protection of an inert gas Ester TEOS was reacted until the solution changed from clear and transparent to milky white (obvious change occurred within about 20 minutes), continued to react for 6 hours, collected by centrifugation, washed repeatedly with ethanol-water solution and vacuum freeze-dried for 8 hours to obtain silica Nanoparticles; ammonia water: ethanol: water: tetraethyl orthosilicate 2:25:25:2, magnetic stirring 600rpm, centrifugal speed 10500rpm / min, 7.5min,

[0063] Step 2: Preparation of silica surface grafted with fluorescein isothiocyanate SiO 2 Polymers by @FITC-APTES;

[...

Embodiment 3

[0071] Include the following steps:

[0072] Step 1: Preparation of silica nanoparticles SiO 2

[0073] First, configure ethanol-deionized water mixed solution, add ammonia water to it, and obtain mixed solution A after ultrasonic treatment for 10 minutes; place mixed solution A at room temperature under magnetic stirring, and slowly add ethyl orthosilicate through a burette under the protection of an inert gas Ester TEOS was reacted until the solution changed from clear and transparent to milky white (obvious change occurred within about 20 minutes), continued to react for 6 hours, collected by centrifugation, washed repeatedly with ethanol-water solution and vacuum freeze-dried for 8 hours to obtain silica Nanoparticles; ammonia water: ethanol: water: tetraethyl orthosilicate 2:25:25:2, magnetic stirring 600rpm, centrifugal speed 11000rpm / min, 5min;

[0074] Step 2: Preparation of silica surface grafted with fluorescein isothiocyanate SiO 2 Polymers by @FITC-APTES;

[00...

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Abstract

The invention relates to a fluorescent molecularly imprinted polymer hollow microsphere, a preparation method and application thereof, and belongs to the technical field of molecularly imprinted polymers. Including the preparation of silica nanoparticles SiO 2 , the preparation of silica surface grafted fluorescein isothiocyanate SiO 2 Polymers by @FITC‑APTES; Fabricating Fluorescent Molecularly Imprinted Polymer SiO 2 @FITC‑APTES@MIP, etched into a hollow fluorescent molecularly imprinted polymer FITC‑APTES@MIP. The advantages are: to prepare a hollow fluorescent molecularly imprinted polymer that can detect target analytes quickly, efficiently and specifically, and the synthesis process is relatively safe and environmentally friendly. Significant quenching effect, resulting in shorter detection times.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, in particular to hollow microspheres of fluorescent molecularly imprinted polymers and a preparation method and application thereof. Background technique [0002] In recent years, more and more attention has been paid to the development of functional materials with characteristic domains through chemical synthesis methods, among which Molecularly Imprinted Polymers (MIP) developed by Molecular Imprinting Technique or Technology (MIT) is one of them. A representative biomimetic functional material, because molecularly imprinted polymers have three characteristics of structural predictability, recognition specificity and application universality and stable physical and chemical properties, simple preparation method, low cost and strong catalytic and degradation ability , so it has received extensive attention in the fields of purification and separation, chemistry, biosensing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C08F220/06C08F220/56C08F226/06C08F222/14G01N21/64
CPCB01J20/268B01J20/28021B01J20/28057C08F220/06C08F220/56C08F226/06G01N21/6428G01N21/643G01N2021/6432C08F222/102
Inventor 吕绍武徐朝建黄一高海成龚平生姜蒙蒙马海霞
Owner JILIN UNIV
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